Transport of fatty acids and metabolites across the peroxisomal membrane
Abstract
The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. Genetic and biochemical studies in the yeast Saccharomyces cerevisiae have identified enzymes for redox shuttles as well as the first peroxisomal membrane transporter. This peroxisomal ATP-binding cassette transporter (Pat) is highly homologous to the gene mutated in X-linked adrenoleukodystrophy (X-ALD). The yeast Pat is required for import of activated fatty acids into peroxisomes suggesting that this is the primary defect in X-ALD.
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The yeast Pxa1p/Pxa2p transporter is involved in the transport of long-chain fatty acyl-CoA esters from the cytoplasm, across the peroxisomal membrane, and into the interior of the peroxisome.
“This transporter somehow is involved in the transport of long-chain fatty acyl-CoA esters from the cytoplasm, across the peroxisomal membrane and into the interior of the peroxisome [Verleur et al., 1997;Hettema and Tabak, 2000].”
From ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: Role in diagnosis and clinical correlations (2001) · cites this paper as Hettema and Tabak, 2000
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References 55 · Cited by 126
- Authors
- Hettema, E. H., & Tabak, H. F.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Tabak, Henk F.
- ORCID
- Hettema, Ewald H.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 1486
- Issue
- 1
- Pages
- 18-27
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2064948539
- Cited by
- 126
- References
- 55
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- PAT, X-linked adrenoleukodystrophy, fatty acid beta-oxidation, redox shuttle, Saccharomyces cerevisiae
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily D, Member 1, Acyl Coenzyme A, Biological Transport, Cytoplasm, Fatty Acids, Intracellular Membranes, Membrane Proteins, Oxidation-Reduction, Saccharomyces cerevisiae, ATP-Binding Cassette Transporters, Peroxisomes
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