Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm
Abstract
Long-chain fatty acids can transfer passively across mammalian cell membranes. However, under physiological conditions of low fatty acid to albumin ratios in the circulation, the major fraction of uptake appears to be mediated by a saturable, protein-facilitated component. A simple diffusion process becomes significant at high molar ratios of fatty acid to albumin as the concentration of free fatty acid in solution is increased. Identification of the mammalian membrane fatty acid transporter(s) has been the focus of active investigation by several research groups. In this review we discuss three candidate proteins: FABPm, FAT/CD36 and FATP which have been cloned and are currently being characterized. Recent evidence arguing for an important role of the fatty acid transport step in general metabolism and linking these proteins to physiologic or metabolic abnormalities is described.
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An increase in plasma free fatty acid concentration is an important regulator of free fatty acid supply to skeletal muscle.
“Thus, an increae in plasma FFA concentration is an important regulator of FFA supply to skeletal muscle [82].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [82]
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References 89 · Cited by 277
- Authors
- Abumrad, N.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Abumrad, N
- ORCID
- Abumrad, N
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 1999-10-18
- Volume
- 1441
- Issue
- 1
- Pages
- 4-13
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2008568914
- Cited by
- 277
- References
- 89
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 6 · 2013: 7 · 2012: 7
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- long-chain fatty acid uptake, fatty acid transporters, CD36, fatty acid binding protein, membrane transporters, albumin, fatty acid metabolism
- MeSH terms
- Fatty Acid-Binding Protein 7, Animals, Biological Transport, Carrier Proteins, Cells, Cultured, Fatty Acids, Humans, Membrane Glycoproteins, Membrane Proteins, Neoplasm Proteins, CD36 Antigens, Myelin P2 Protein, Tumor Suppressor Proteins, Membrane Transport Proteins, Organic Anion Transporters, Fatty Acid-Binding Proteins, Fatty Acid Transport Proteins
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