The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Importance of Anemia and its Correction in the Management of Severe Congestive Heart Failures
Abstract
About half of all the patients with CHF are anemic (they have a hemoglobin of <12 g%). The prevalence and severity of this anemia increase with increasing severity of the CHF. The anemia is caused by a combination of poor nutrition, associated renal insufficiency causing inappropriately low Erythropoietin (EPO) levels, bone marrow depression and EPO resistance caused by excessive TNF alpha and other factors, gastrointestinal blood loss caused by aspirin, ACE inhibitors, EPO loss in the urine with proteinuria, and hemodilution caused by the excessive plasma volume. Studies have shown that the anemia is an independent risk factor for death in CHF, almost doubling the mortality rate. Correction of the anemia with subcutaneous EPO and IV iron improves cardiac function and functional capacity, helps prevent the progression of renal failure, markedly reduces hospitalization and diuretic doses, and improves self assessed quality of life. This so-called Cardio Renal Anemia Syndrome is very common in CHF. Its successful treatment demands close cooperation between cardiologists and nephrologists.
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Besarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930
Horwich, T. B., Fonarow, G. C., Hamilton, M. A., MacLellan, W. R., & Borenstein, J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01854-5 · Cited by 712
Cited by
Anemia and Mortality in Heart Failure Patients
Groenveld, H. F., Januzzi, J. L., Damman, K., van Wijngaarden, J., Hillege, H. L., van Veldhuisen, D. J., & van der Meer, P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.061 · Cited by 764
Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project
Kosiborod, M., Curtis, J. P., Wang, Y., Smith, G. L., Masoudi, F. A., Foody, J. M., Havranek, E. P., & Krumholz, H. M. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.19.2237 · Cited by 142
Metadata
- Authors
- Silverberg, D. S., Wexler, D., & Iaina, A.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-25
- Volume
- 4
- Issue
- 6
- Pages
- 681-686
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W1997754364
- Cited by
- 170
- References
- 2
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Silverberg, D. S., Wexler, D., & Iaina, A. (2002). The Importance of Anemia and its Correction in the Management of Severe Congestive Heart Failures. European Journal of Heart Failure. https://doi.org/10.1016/s1388-9842(02)00115-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
