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Cited by 51Sepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyTrauma, Hemostasis, Coagulopathy, Resuscitation

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Study protocol for the Balanced Solution versus Saline in Intensive Care Study (BaSICS): a factorial randomised trial

Open access
Zampieri, Fernando G., Azevedo, Luciano C.P., Corrêa, Thiago D., Falavigna, Maicon, Machado, Flavia R., de Assunção, Murillo S.C., Lobo, Suzana M.A., Dourado, Letícia K., Berwanger, Otavio, Kellum, John A., Brandão, Nilton, Cavalcanti, Alexandre B.·2017·Critical Care and Resuscitation
DOI 10.1016/s1441-2772(23)00790-1
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Abstract

BACKGROUND: The effectiveness and safety of balanced crystalloid fluids compared with saline (0.9% sodium chloride) as a fluid of choice in critically ill patients remain unclear. The effects of different fluid infusion rates on outcomes are also unknown. OBJECTIVES: To test the hypothesis that a balanced crystalloid solution, compared with saline, decreases 90-day all-cause mortality among critically ill patients; and to test the hypothesis that slow, compared with rapid, infusion rate decreases 90-day mortality in this population of patients. METHODS: The Balanced Solution versus Saline in Intensive Care Study (BaSICS) is a pragmatic, 2 ??2 factorial, randomised controlled trial. A total of 11 000 patients will be recruited from at least 100 Brazilian intensive care units. Patients will be randomised to receive Plasma-Lyte 148 or saline, and to rapid infusion (999 mL/h) or slow infusion (333 mL/h). Study fluids will be used for resuscitation episodes (at rapid or slow infusion rates), dilution of compatible medications and maintenance solutions. Patients, health care providers and investigators will be blinded to the solutions being tested. The rate of bolus infusion will not be blinded. OUTCOMES: The primary outcome is 90-day all-cause mortality. Secondary outcomes are: incidence of renal failure requiring renal replacement therapy within 90 days, incidence of acute kidney injury (Kidney Disease: Improving Global Outcomes stages 2 and 3), incidence of non-renal organ dysfu…

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Crossref · 10.1016/s1441-2772(23)00790-1

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3 of 3 references verified0 citation errors · 0 not checkable

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  • Smaller studies suggest that source control within 6 to 12 hours is advantageous.

    “While there are limited data to conclusively issue a recommendation regarding the timeframe in which source control should be obtained, smaller studies suggest that source control within 6 to 12 hours is advantageous (265-271).”

    From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [265]

Citations

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Research works printed but not linked: 20

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  2. Zhou, 2014, Effects of fluid resuscitation with 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis, Crit Care Med, 42, e270, 10.1097/CCM.0000000000000145 · DOI
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  4. Zampieri, 2016, Lactated Ringer is associated with reduced mortality and less acute kidney injury in critically ill patients: a retrospective cohort analysis, Crit Care Med, 44, 2163, 10.1097/CCM.0000000000001948 · DOI
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Metadata

Authors
Zampieri, F. G., Azevedo, L. C. P., Corrêa, T. D., Falavigna, M., Machado, F. R., de Assunção, M. S. C., Lobo, S. M. A., Dourado, L. K., Berwanger, O., Kellum, J. A., Brandão, N., & Cavalcanti, A. B.
Affiliations
  • Hospital do Coração (BR)
  • Universidade de São Paulo (BR)
  • Hospital Israelita Albert Einstein (BR)
  • Hospital Moinhos de Vento (BR)
  • Faculdade de Medicina de São José do Rio Preto (BR)
  • University of Pittsburgh (US)
Corresponding author
Cavalcanti, Alexandre B.
ORCID
Venue
Critical Care and Resuscitation
Publisher
Elsevier BV
Published
2017-06
Volume
19
Issue
2
Pages
175-182.e8
ISSN
1441-2772 (ISSN-L)
DOI
10.1016/s1441-2772(23)00790-1
OpenAlex
W4387760500
Cited by
51
References
3
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 13 · 2020: 3 · 2019: 11 · 2018: 13 · 2017: 3
FWCI
6.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Critical Care and Resuscitation (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
  • PubMed
Funders
Ministério da Saúde
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
saline, fluid resuscitation, infusion rate, bolus infusion, critically ill patients, 90-day mortality, acute kidney injury, renal replacement therapy, organ dysfunction, mechanical ventilation, Plasma-Lyte 148, intensive care
MeSH terms
Aged, Brazil, Cause of Death, Double-Blind Method, Fluid Therapy, Gluconates, Humans, Infusions, Intravenous, Intensive Care Units, Potassium Chloride, Research Design, Sodium Chloride, Magnesium Chloride, Critical Illness, Hospital Mortality, Patient Selection, Sodium Acetate

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