Cationic peptides: effectors in innate immunity and novel antimicrobials
Abstract
Cationic antimicrobial peptides are produced by all organisms, from plants and insects to human beings, as a major part of their immediately effective, non-specific defences against infections. With the increasing development of antibiotic resistance among key bacterial pathogens, there is an urgent need to discover novel classes of antibiotics. Therefore, cationic peptides are being developed through clinical trials as anti-infective agents. In addition to their ability to kill microbes, these peptides seem to have effector functions in innate immunity and can upregulate the expression of multiple genes in eukaryotic cells. One such function might involve the dampening of signalling by bacterial molecules such as lipopolysaccharide and lipoteichoic acid.
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Antimicrobial peptides (AMPs) induced by bacterial infections are small, active peptides with the capability to stimulate the innate immune activity of living organisms.
“Antimicrobial peptides (AMPs) induced by bacterial infections are small, active peptides with the capability to stimulate the innate immune activity of living organisms.49”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [49]
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- Authors
- Hancock, R. E.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Hancock, Robert EW
- ORCID
- Hancock, Robert EW
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 1
- Issue
- 3
- Pages
- 156-164
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2131192673
- Cited by
- 978
- References
- 53
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 30 · 2023: 32 · 2022: 40 · 2021: 31 · 2020: 49 · 2019: 34 · 2018: 47 · 2017: 36 · 2016: 52 · 2015: 54 · 2014: 50 · 2013: 50 · 2012: 48
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- cationic antimicrobial peptides, innate immunity, antibiotic resistance, novel antimicrobial agents, anti-infective agents, lipoteichoic acid, gene upregulation, pathogenic bacteria
- MeSH terms
- Amino Acid Sequence, Animals, Anti-Infective Agents, Anti-Infective Agents, Local, Anti-Bacterial Agents, Cations, Gramicidin, Humans, Immunity, Innate, Molecular Sequence Data, Polymyxin B
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