Cited by 400Antibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusAntibiotic Use and Resistance

The DOI matches its Crossref record; 102 of the 104 references it cites were found in a registry or an index.

Vancomycin-resistant enterococci: why are they here, and where do they come from?

Bonten, Marc JM, Willems, Rob, Weinstein, Robert A·2001·The Lancet Infectious Diseases

Open this paper in CoChat — free account

Abstract

Vancomcyin-resistant enterococci (VRE) have emerged as nosocomial pathogens in the past 10 years, causing epidemiological controversy. In the USA, colonisation with VRE is endemic in many hospitals and increasingly causes infection, but colonisation is absent in healthy people. In Europe, outbreaks still happen sporadically, usually with few serious infections, but colonisation seems to be endemic in healthy people and farm animals. Vancomycin use has been much higher in the USA, where emergence of ampicillin-resistant enterococci preceded emergence of VRE, making them very susceptible to the selective effects of antibiotics. In Europe, avoparcin, a vancomycin-like glycopeptide, has been widely used in the agricultural industry, explaining the community reservoir in European animals. Avoparcin has not been used in the USA, which is consistent with the absence of colonisation in healthy people. From the European animal reservoir, VRE and resistance genes have spread to healthy human beings and hospitalised patients. However, certain genogroups of enterococci in both continents seem to be more capable of causing hospital outbreaks, perhaps because of the presence of a specific virulence factor, the variant esp gene. By contrast with the evidence of a direct link between European animal and human reservoirs, the origin of American resistance genes remains to be established. Considering the spread of antibiotic-resistant bacteria and resistance genes, the emergence of VRE has emphasised the non-existence of boundaries between hospitals, between people and animals, between countries, and probably between continents.

Integrity signals

Registry

Crossref · 10.1016/s1473-3099(01)00145-1

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium
Leclercq, R., Derlot, E., Duval, J., & Courvalin, P. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807213190307 · Cited by 1,411
Epidemiology of Drug Resistance: Implications for a Post—Antimicrobial Era
Cohen, M. L. (1992) · Science · doi:10.1126/science.257.5073.1050 · Cited by 1,310
VANCOMYCIN-RESISTANT ENTEROCOCCI
Uttley, A. C., Collins, C. H., Naidoo, J., & George, R. C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91037-9 · Cited by 1,237
Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus
Noble, W. C., Virani, Z., & Cree, R. G. A. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90528-v · Cited by 935
Recommendations for Preventing the Spread of Vancomycin Resistance
(1995) · Infection Control and Hospital Epidemiology · doi:10.1086/647066 · Cited by 902
National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1990-May 1999, Issued June 1999
(1999) · American Journal of Infection Control · doi:10.1016/s0196-6553(99)70031-3 · Cited by 899
Vancomycin-Resistant Enterococcal Infections
Murray, B. E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003093421007 · Cited by 894
Effect of Antibiotic Therapy on the Density of Vancomycin-Resistant Enterococci in the Stool of Colonized Patients
Donskey, C. J., Chowdhry, T. K., Hecker, M. T., Hoyen, C. K., Hanrahan, J., Hujer, A. M., Hutton‐Thomas, R., Whalen, C. C., Bonomo, R. A., & Rice, L. B. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012283432604 · Cited by 691
Effect of Abolishment of the Use of Antimicrobial Agents for Growth Promotion on Occurrence of Antimicrobial Resistance in Fecal Enterococci from Food Animals in Denmark
Aarestrup, F. M., Seyfarth, A. M., Emborg, H., Pedersen, K., Hendriksen, R. S., & Bager, F. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.7.2054-2059.2001 · Cited by 653
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147
Arthur, M., Molinas, C., Depardieu, F., & Courvalin, P. M. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.1.117-127.1993 · Cited by 600

Show all 104 references

Research works printed but not linked: 5

Hayden MK, Blom DW, Lyle EA, et al. The risk of hand and glove contamination by health care workers after contact with a VRE-positive patient or the patients' environment. Proceedings of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago; Dec 2001: abstract K/1334
Vandenbroucke-Grauls, 2000, Succesvolle bestrijding van een epidemie met vancomycineresistente Enterococcus faecium op een hematologische afdeling, Ned Tijdschr Med Microbiol, 8, S28
van der Steen, 2000, Uitbraak van vancomycine-resistente Enterococcus faecium op een afdeling nefrologie, Ned Tijdschr Geneesk, 144, 2568
Mascini, 2000, Epidemische verheffing van verscheidene genotypen van vancomycine-resistente Enterococcus faecium in een Academisch Ziekenhuis, Ned Tijdschr Geneesk, 144, 2572
Routsi, 2001, Clinical and molecular surveillance of glycopeptide-resistant Enterococcus faecium in a Greek ICU, Intens Care Med, 27, S151

Sorted by citations

Antibiotic Resistance Genes as Emerging Contaminants: Studies in Northern Colorado
Pruden, A. J., Pei, R., Storteboom, H. N., & Carlson, K. H. (2006) · Environmental Science & Technology · doi:10.1021/es060413l · Cited by 1,943
Environmental Contamination Due to Methicillin-Resistant Staphylococcus aureus: Possible Infection Control Implications
Boyce, J. M., Potter-Bynoe, G., Chenevert, C., & King, T. (1997) · Infection Control and Hospital Epidemiology · doi:10.1086/502213 · Cited by 1,758
Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America
Solomkin, J. S., Mazuski, J. E., Bradley, J. S., Rodvold, K. A., Goldstein, E. J. C., Baron, E. J., O’Neill, P. J., Chow, A. W., Dellinger, E. P., Eachempati, S. R., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/649554 · Cited by 1,571
Policy Statement on Antimicrobial Stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS)
Fishman, N. O., Society for Healthcare Epidemiology of America, Infectious Diseases Society of America, & Pediatric Infectious Diseases Society (2012) · Infection Control and Hospital Epidemiology · doi:10.1086/665010 · Cited by 683
Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?
von Nussbaum, F., Brands, M., Hinzen, B., Weigand, S., & Häbich, D. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600350 · Cited by 682
Diagnosis and Management of Complicated Intra-Abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America
Solomkin, J. S., Mazuski, J. E., Bradley, J. S., Rodvold, K. A., Goldstein, E. J. C., Baron, E. J., O’Neill, P. J., Chow, A. W., Dellinger, E. P., Eachempati, S. R., et al. (2010) · Surgical Infections · doi:10.1089/sur.2009.9930 · Cited by 620
Antibiotics in agriculture and the risk to human health: how worried should we be?
Chang, Q., Wang, W., Regev‐Yochay, G., Lipsitch, M., & Hanage, W. P. (2014) · Evolutionary Applications · doi:10.1111/eva.12185 · Cited by 574
Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex
Willems, R. J. L., Top, J., van Santen, M., Robinson, D. A., Coque, T. M., Baquero, F., Grundmann, H., & Bonten, M. J. M. (2005) · Emerging infectious diseases · doi:10.3201/eid1106.041204 · Cited by 577
Self-citation
Emergence and spread of vancomycin resistance among enterococci in Europe
Werner, G., Coque, T. M., Hammerum, A. M., Hope, R., Hryniewicz, W., Johnson, A. P., Klare, I., Kristinsson, K. G., Leclercq, R., Lester, C. H., et al. (2008) · Eurosurveillance · doi:10.2807/ese.13.47.19046-en · Cited by 529
Self-citation
Vancomycin-resistant enterococcal infections: epidemiology, clinical manifestations, and optimal management
Crank, C. W., & O’Driscoll, T. (2015) · Infection and Drug Resistance · doi:10.2147/idr.s54125 · Cited by 518
Safety assessment of dairy microorganisms: The Enterococcus genus
Ogier, J.-C., & Serror, P. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.08.017 · Cited by 404
Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program
Deshpande, L. M., Fritsche, T. R., Moet, G. J., Biedenbach, D. J., & Jones, R. N. (2007) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2006.12.022 · Cited by 343
Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance
Leavis, H. L., Bonten, M. J. M., & Willems, R. J. L. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.07.001 · Cited by 321
Self-citation
Survey for virulence determinants among Enterococcus faecalis isolated from different sources
Creti, R., Imperi, M., Bertuccini, L., Fabretti, F., Orefici, G., Rosa, R., & Baldassarri, L. (2003) · Journal of Medical Microbiology · doi:10.1099/jmm.0.05353-0 · Cited by 319
Core Genome Multilocus Sequence Typing Scheme for High-Resolution Typing of Enterococcus faecium
de Been, M., Pinholt, M., Top, J., Bletz, S., Mellmann, A., van Schaik, W., Brouwer, E. C., Rogers, M. R. C., Kraat, Y., Bonten, M. J. M., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.01946-15 · Cited by 317
Self-citation
Comparison of the incidence of virulence determinants and antibiotic resistance between Enterococcus faecium strains of dairy, animal and clinical origin
Mannu, L., Paba, A., Daga, E., Comunian, R., Zanetti, S., Dupré, I., & Sechi, L. A. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(03)00191-0 · Cited by 290
Emergence of CC17Enterococcus faecium: from commensal to hospital-adapted pathogen
Top, J., Willems, R. J. L., & Bonten, M. J. M. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00383.x · Cited by 265
Self-citation
Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics
Mubeen, B., Ansar, A. N., Rasool, R., Ullah, I., Imam, S. S., Alshehri, S., Ghoneim, M. M., Alzarea, S. I., Nadeem, M. S., & Kazmi, I. A. (2021) · Antibiotics · doi:10.3390/antibiotics10121473 · Cited by 257
Safety aspects of enterococci from the medical point of view
Kayser, F. H. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(03)00188-0 · Cited by 241
Zinc and copper in animal feed – development of resistance and co-resistance to antimicrobial agents in bacteria of animal origin
Yazdankhah, S., Rudi, K., & Bernhoft, A. (2014) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v25.25862 · Cited by 127
Combination drugs, an emerging option for antibacterial therapy
Cottarel, G., & Wierzbowski, J. (2007) · Trends in biotechnology · doi:10.1016/j.tibtech.2007.09.004 · Cited by 238
Enterococcus faecalis– the root canal survivor and ‘star’ in post‐treatment disease
Portenier, I., Waltimo, T. M. T., & Haapasalo, M. (2003) · Endodontic Topics · doi:10.1111/j.1601-1546.2003.00040.x · Cited by 231
Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce?
Cattoir, V., & Leclercq, R. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks469 · Cited by 241
Enterococcus faecium: from microbiological insights to practical recommendations for infection control and diagnostics
Zhou, X. W., Willems, R. J. L., Friedrich, A. W., Rossen, J. W. A., & Bathoorn, E. (2020) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-020-00770-1 · Cited by 230
Self-citation
Glycopeptide Antibiotics
Françoise Van Bambeke, A., Laethem, Y. V., Courvalin, P. M., & Tulkens, P. M. (2004) · Drugs · doi:10.2165/00003495-200464090-00001 · Cited by 219
Vancomycin Revisited – 60 Years Later
Rubinstein, E., & Keynan, Y. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00217 · Cited by 209
Colonization, Bloodstream Infection, and Mortality Caused by Vancomycin-Resistant Enterococcus Early after Allogeneic Hematopoietic Stem Cell Transplant
Weinstock, D. M., Conlon, M., Iovino, C. S., Aubrey, T., Gudiol, C., Riedel, E., Young, J. W., Kiehn, T. E., & Zuccotti, G. (2007) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2007.01.078 · Cited by 209
Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance
Willems, R. J. L., Hanage, W. P., Bessen, D. E., & Feil, E. J. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00284.x · Cited by 207
Self-citation
Restricted Gene Flow among Hospital Subpopulations of Enterococcus faecium
Willems, R. J. L., Top, J., van Schaik, W., Leavis, H. L., Bonten, M. J. M., Sirén, J., Hanage, W. P., & Corander, J. (2012) · mBio · doi:10.1128/mbio.00151-12 · Cited by 209
Self-citation
Characterization and safety evaluation of enterococci isolated from Spanish goats' milk cheeses
Martín-Platero, A. M., Valdivia, E., Maqueda, M., & Martínez‐Bueno, M. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.03.010 · Cited by 199
Vancomycin-Resistant Enterococci: Colonization, Infection, Detection, and Treatment
Zirakzadeh, A. A., & Patel, R. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.4.529 · Cited by 193
Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problem
Smith, D. L., Dushoff, J. G., Perencevich, E. N., Harris, A. D., & Levin, S. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400456101 · Cited by 192
Mechanisms of β-lactam antimicrobial resistance and epidemiology of major community- and healthcare-associated multidrug-resistant bacteria
Tang, S. S. L., Apisarnthanarak, A., & Hsu, L. Y. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.08.003 · Cited by 189
Enterococci, from Harmless Bacteria to a Pathogen
Ramos, S., SILVA, V. Y. N. E. D., Dapkevicius, M. D. L. E., Igrejas, G., & Poeta, P. A. C. Q. D. (2020) · Microorganisms · doi:10.3390/microorganisms8081118 · Cited by 185
From pieces to patterns: evolutionary engineering in bacterial pathogens
Baquero, F. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro909 · Cited by 186
Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals
Klare, I., Konstabel, C., Müller-Bertling, S., Werner, G., Strommenger, B., Kettlitz, C., Borgmann, S., Schulte, B., Jonas, D., Serr, A., et al. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-005-0056-0 · Cited by 166
Multilevel population genetic analysis of vanA and vanB Enterococcus faecium causing nosocomial outbreaks in 27 countries (1986–2012)
Freitas, A. R., Tedim, A. P., Francia, M. V., Jensen, L., Novais, C., Peixe, L. M. S. V., Valenzuela, A. S., Sundsfjord, A., Hegstad, K., Werner, G., et al. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw312 · Cited by 163
Self-citation
The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile
Carter, G. P., Douce, G. R., Govind, R., Howarth, P. M., Mackin, K. E., Spencer, J., Buckley, A. M., Antunes, A. P. D. O. L., Kotsanas, D., Jenkin, G., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002317 · Cited by 158
Relationship between biofilm formation, the enterococcal surface protein (Esp) and gelatinase in clinical isolates ofEnterococcus faecalisandEnterococcus faecium
Rosa, R., Creti, R., Venditti, M., D’Amelio, R., Arciola, C. R., Montanaro, L., & Baldassarri, L. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00112.x · Cited by 157
Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration
D’Agata, E. M. C., Magal, P., Olivier, D., Ruan, S., & Webb, G. F. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.08.011 · Cited by 155
Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance?
von Nussbaum, F., Brands, M., Hinzen, B., Weigand, S., & Häbich, D. (2006) · Angewandte Chemie · doi:10.1002/ange.200600350 · Cited by 153
Comparative Analysis of the First Complete Enterococcus faecium Genome
Lam, M. M. C., Seemann, T., Bulach, D., Gladman, S. L., Chen, H., Haring, V. R., Moore, R. J., Ballard, S. A., Grayson, M. L., Johnson, P. D. R., et al. (2012) · Journal of Bacteriology · doi:10.1128/jb.00259-12 · Cited by 152
Horizontal gene transfer-emerging multidrug resistance in hospital bacteria.
SenkaDZIDIC, & VladimirBEDEKOVIC (2003) · PubMed · Cited by 152
Determining incidence of extended spectrum β-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001–2002
Bouchillon, S. K., Johnson, B., Hoban, D., Johnson, J. L., Dowzicky, M. J., Wu, D., Visalli, M. A., & Bradford, P. A. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2004.01.010 · Cited by 141
Plasmids Shaped the Recent Emergence of the Major Nosocomial Pathogen Enterococcus faecium
Arredondo-Alonso, S., Top, J., McNally, A., Puranen, S., Pesonen, M., Pensar, J., Marttinen, P., Braat, J. C., Rogers, M. R. C., van Schaik, W., et al. (2020) · mBio · doi:10.1128/mbio.03284-19 · Cited by 144
Self-citation
A review of ARGs in WWTPs: Sources, stressors and elimination
Qin, K., Wei, L., Jian-ju, L., Lai, B., Zhu, F., Yu, H., Zhao, Q., & Wang, K. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.04.057 · Cited by 137
Multiple-Locus Variable-Number Tandem Repeat Analysis, a Novel Typing Scheme To Study the Genetic Relatedness and Epidemiology of Enterococcus faecium Isolates
Top, J., Schouls, L. M., Bonten, M. J. M., & Willems, R. J. L. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4503-4511.2004 · Cited by 135
Self-citation
Use of Bacteriocins and Bacteriocinogenic Beneficial Organisms in Food Products: Benefits, Challenges, Concerns
Todorov, S. D., Popov, I. V., Weeks, R. M., & Chikindas, M. L. (2022) · Foods · doi:10.3390/foods11193145 · Cited by 134
Vancomycin resistant enterococci: From the hospital effluent to the urban wastewater treatment plant
Varela, A. R., Ferro, G., Vredenburg, J., Yanık, M., Vieira, L., Rizzo, L., Lameiras, C., & Manaia, C. M. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.02.015 · Cited by 124
Inappropriate use of antibiotics in hospitals: The complex relationship between antibiotic use and antimicrobial resistance
Cantón, R., Horcajada, J. P., Oliver, A., Garbajosa, P. R., & Vilà, J. (2013) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(13)70126-5 · Cited by 123
Strategic interactions in multi-institutional epidemics of antibiotic resistance
Smith, D. L., Levin, S. A., & Laxminarayan, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409523102 · Cited by 120
Agricultural Antibiotics and Human Health
Smith, D. L., Dushoff, J. G., & Morris, J. G. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020232 · Cited by 120
Managing methicillin-resistant staphylococci: A paradigm for preventing nosocomial transmission of resistant organisms
Henderson, D. K. (2006) · American Journal of Infection Control · doi:10.1016/j.ajic.2006.05.228 · Cited by 120
Vancomycin resistant enterococci in farm animals – occurrence and importance
Nilsson, O. (2012) · Infection Ecology & Epidemiology · doi:10.3402/iee.v2i0.16959 · Cited by 119
Enterococcus faecalis Overcomes Foreign Body-Mediated Inflammation To Establish Urinary Tract Infections
Guiton, P. S., Hannan, T. J., Ford, B. A., Caparon, M. G., & Hultgren, S. J. (2012) · Infection and Immunity · doi:10.1128/iai.00856-12 · Cited by 114
Glycopeptides in clinical development: pharmacological profile and clinical perspectives
Françoise Van Bambeke, A. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.04.006 · Cited by 114
Prevalence and Antimicrobial Resistance of Enterococcus Species: A Hospital-Based Study in China
Jia, W., Li, G., & Wang, W. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110303424 · Cited by 112
Elevated Risk of Carrying Gentamicin-Resistant Escherichia coli among U.S. Poultry Workers
Price, L. B., Graham, J. P., Lackey, L. G., Roess, A., Vailes, R., & Silbergeld, E. K. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10191 · Cited by 110
High-Level Ciprofloxacin Resistance from Point Mutations in gyrA and parC Confined to Global Hospital-Adapted Clonal Lineage CC17 of Enterococcus faecium
Leavis, H. L., Willems, R. J. L., Top, J., & Bonten, M. J. M. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.3.1059-1064.2006 · Cited by 110
Self-citation
Gene transfer of vancomycin and tetracycline resistances among Enterococcus faecalis during cheese and sausage fermentations
Cocconcelli, P. S., Cattivelli, D., & Gazzola, S. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(03)00194-6 · Cited by 109
Do We Need to Put Society First? The Potential for Tragedy in Antimicrobial Resistance
Foster, K. R., & Grundmann, H. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030029 · Cited by 111
Emergence of Clonal Complex 17 Enterococcus faecium in The Netherlands
Top, J., Willems, R. J. L., van der Velden, S., van Luit‐Asbroek, M., & Bonten, M. J. M. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01351-07 · Cited by 106
Self-citation
Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections
Cairns, K. A., Udy, A. A., Peel, T. N., Abbott, I. J., Dooley, M. J., & Peleg, A. Y. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00059-22 · Cited by 108
Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization
Horrocks, V., King, O. G., Yip, A. Y. G., Marques, I. M., & McDonald, J. A. K. (2023) · Microbiology · doi:10.1099/mic.0.001377 · Cited by 104
Glycopeptides: Update on an old successful antibiotic class
Pace, J., & Yang, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.005 · Cited by 107
Lactobacillus rhamnosus GG Outcompetes Enterococcus faecium via Mucus-Binding Pili: Evidence for a Novel and Heterospecific Probiotic Mechanism
Tytgat, H. L. P., Douillard, F. P., Reunanen, J., Rasinkangas, P., Hendrickx, A. P. A., Laine, P., Paulin, L. G., Satokari, R. M., & de Vos, W. M. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.01243-16 · Cited by 103
Urinary tract infection and subclinical bacteriuria in cats: A clinical update
Dorsch, R., Teichmann-Knorrn, S., & Lund, H. S. (2019) · Journal of Feline Medicine and Surgery · doi:10.1177/1098612x19880435 · Cited by 99
Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environments
Pérez, M., Calles-Enríquez, M., Nes, I. F., Martín, M. C., Fernández, M., Ladero, V., & Álvarez, M. A. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-6301-7 · Cited by 98
VanA-Type Enterococci from Humans, Animals, and Food: Species Distribution, Population Structure, Tn 1546 Typing and Location, and Virulence Determinants
Biavasco, F., Foglia, G., Paoletti, C., Zandri, G., Magi, G., Guaglianone, E., Sundsfjord, A., Pruzzo, C., Donelli, G., & Facinelli, B. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02239-06 · Cited by 97
Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci
Kainer, M. A., Devasia, R. A., Jones, T. F., Simmons, B. P., Melton, K., Chow, S., Broyles, J., Moore, K. L., Craig, A. S., & Schaffner, W. (2007) · Emerging Infectious Diseases · doi:10.3201/eid1307.070019 · Cited by 96
Population Biology of Intestinal Enterococcus Isolates from Hospitalized and Nonhospitalized Individuals in Different Age Groups
Tedim, A. P., Ruíz-Garbajosa, P., Corander, J., Rodríguez, C. M., Cantón, R., Willems, R. J. L., Baquero, F., & Coque, T. M. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.03661-14 · Cited by 92
Self-citation
Antimicrobial Stewardship in the Hospital Setting: A Narrative Review
Giamarellou, H., Galani, L., Karavasilis, T., Ioannidis, K., & Karaiskos, I. (2023) · Antibiotics · doi:10.3390/antibiotics12101557 · Cited by 91
Population Structure of Enterococcus faecium Causing Bacteremia in a Spanish University Hospital: Setting the Scene for a Future Increase in Vancomycin Resistance?
Coque, T. M., Willems, R. J. L., Fortün, J., Top, J., Diz, S. D. L., Loza, E., Cantón, R., & Baquero, F. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.7.2693-2700.2005 · Cited by 90
Self-citation
Strong biofilm production, antibiotic multi-resistance and high gelE expression in epidemic clones of Enterococcus faecalis from orthopaedic implant infections
Arciola, C. R., Baldassarri, L., Campoccia, D., Creti, R., Pirini, V., Hüebner, J., & Montanaro, L. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.008 · Cited by 89
Antimicrobial resistance and virulence traits of Enterococcus faecalis from primary endodontic infections
Lins, R. X., Andrade, A. D. O., Hirata, R., Wilson, M. J., Lewis, M. A. O., Williams, D. W., & Fidel, R. A. S. (2013) · Journal of Dentistry · doi:10.1016/j.jdent.2013.07.004 · Cited by 88
Combatting resistant enterococcal infections: a pharmacotherapy review
Mercuro, N. J., Davis, S. L., Zervos, M., & Herc, E. S. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1479397 · Cited by 87
The clinical importance of emerging ESKAPE pathogens in nosocomial infections
Navidinia, M. (2016) · Archives of Advances in Biosciences · doi:10.22037/jps.v7i3.12584 · Cited by 86
Virulence and antimicrobial resistance factors of Enterococcusspp. isolated from fecal samples from piggery farms in Eastern Cape, South Africa
Iweriebor, B. C., Obi, L. C., & Okoh, A. I. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0468-7 · Cited by 84
Nosocomial bacterial infections in Intensive Care Units. I: Organisms and mechanisms of antibiotic resistance
Lim, S. ‐., & Webb, S. A. R. (2005) · Anaesthesia · doi:10.1111/j.1365-2044.2005.04220.x · Cited by 84
Multidrug-Resistant Bacterial Infections in Solid Organ Transplant Candidates and Recipients
Bartoletti, M., Giannella, M., Tedeschi, S., & Viale, P. (2018) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2018.04.004 · Cited by 83
Acquired Vancomycin Resistance in Clinically Relevant Pathogens
Werner, G., Strommenger, B., & Witte, W. (2008) · Future Microbiology · doi:10.2217/17460913.3.5.547 · Cited by 84
The multifaceted lifestyle of enterococci: genetic diversity, ecology and risks for public health
Cattoir, V. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.10.013 · Cited by 81
Assessing risks for a pre-emergent pathogen: virginiamycin use and the emergence of streptogramin resistance in Enterococcus faecium
Smith, D. L., Johnson, J., Harris, A., Furuno, J. P., Perencevich, E. N., & Jg, M. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00581-4 · Cited by 79
Guidance on the safety assessment of Enterococcus faecium in animal nutrition
(FEEDAP), E. P. O. A. A. P. O. S. U. I. A. F. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2682 · Cited by 79
The importance of adjusting for enterococcus species when assessing the burden of vancomycin resistance: a cohort study including over 1000 cases of enterococcal bloodstream infections
Kramer, T. S., Remschmidt, C., Werner, S., Behnke, M., Schwab, F., Werner, G., Gastmeier, P., & Leistner, R. (2018) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-018-0419-9 · Cited by 78
Distribution of the erm (B) Gene, tet racycline Resistance Genes, and Tn 1545 -like Transposons in Macrolide- and Lincosamide-Resistant Enterococci from Pigs and Humans
Leener, E. D., Martel, A., Decostere, A., & Haesebrouck, F. (2004) · Microbial Drug Resistance · doi:10.1089/mdr.2004.10.341 · Cited by 78
Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin
Sadowy, E., & Łuczkiewicz, A. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-66 · Cited by 78
Diversity of Tn 1546 and Its Role in the Dissemination of Vancomycin-Resistant Enterococci in Portugal
Novais, C., Freitas, A. R., Sousa, J. C., Baquero, F., Coque, T. M., & Peixe, L. M. S. V. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00999-07 · Cited by 76
Vancomycin-resistant enterococcal colonization appears associated with increased mortality among allogeneic hematopoietic stem cell transplant recipients
Zirakzadeh, A. A., Gastineau, D. A., Mandrekar, J. N., Burke, J. P., Johnston, P. B., & Patel, R. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705912 · Cited by 73
Vancomycin-Resistant Enterococci Colonization Among Dialysis Patients: A Meta-analysis of Prevalence, Risk Factors, and Significance
Zacharioudakis, I. M., Zervou, F. N., Ziakas, P. D., Rice, L. B., & Mylonakis, E. E. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.05.016 · Cited by 73
Effect of a genetically engineered bacteriophage on Enterococcus faecalis biofilms
Tinoco, J. M. M., Buttaro, B. A., Zhang, H., Liss, N., Sassone, L. M., & Stevens, R. H. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.07.001 · Cited by 72
In Silico and In Vivo Evaluation of Bacteriophage φEF24C, a Candidate for Treatment of Enterococcus faecalis Infections
Uchiyama, J., Rashel, M., Takemura, I., Wakiguchi, H., & Matsuzaki, S. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02371-07 · Cited by 68
Bacterial resistance: A sensitive issueComplexity of the challenge and containment strategy in Europe
Jansen, W. T. M., VANDERBRUGGEN, J., Verhoef, J., & Fluit, A. C. (2006) · Drug Resistance Updates · doi:10.1016/j.drup.2006.06.002 · Cited by 69
Identification and characterization of enterococci from bryndza cheese
Jurkovič, D., Križková, L., Dušinský, R., Belicová, A., Sojka, M., Krajčovič, J., & Ebringer, L. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.01918.x · Cited by 69
Genetic modifications to temperate Enterococcus faecalis phage ϕEf11 that abolish the establishment of lysogeny and sensitivity to repressor, and increase host range and productivity of lytic infection
Zhang, H., Fouts, D. E., DePew, J., & Stevens, R. H. (2013) · Microbiology · doi:10.1099/mic.0.067116-0 · Cited by 68
Evaluation of resistance genes and virulence factors in a food isolated Enterococcus durans with potential probiotic effect
Pieniz, S., de Moura, T. M., Cassenego, A. P. V., Andreazza, R., Frazzon, A. P. G., Camargo, F. A. D. O., & Brandelli, A. (2014) · Food Control · doi:10.1016/j.foodcont.2014.11.012 · Cited by 68
Consequences of vancomycin‐resistant Enterococcus in liver transplant recipients: a matched control study
Gearhart, M. M., Martin, J. E., Rudich, S. M., Thomas, M., Wetzel, D., Solomkin, J. S., Hanaway, M. J., Aranda‐Michel, J., Weber, F. L., Trumball, L., et al. (2005) · Clinical Transplantation · doi:10.1111/j.1399-0012.2005.00362.x · Cited by 68
Antibiotic Use in Hispanic Households, New York City
Larson, E., Lin, S. X., & Gomez-Duarte, C. (2003) · Emerging infectious diseases · doi:10.3201/eid0909.020371 · Cited by 67
Cloxacillin versus vancomycin for presumed late-onset sepsis in the Neonatal Intensive Care Unit and the impact upon outcome of coagulase negative staphylococcal bacteremia: a retrospective cohort study
Lawrence, S. L., Roth, V. R., Slinger, R., Toye, B., Gaboury, I., & Lemyre, B. (2005) · BMC Pediatrics · doi:10.1186/1471-2431-5-49 · Cited by 67
Comparative analysis of the complete genome of an epidemic hospital sequence type 203 clone of vancomycin-resistant Enterococcus faecium
Lam, M. M. C., Seemann, T., Tobias, N. J., Chen, H., Haring, V. R., Moore, R. J., Ballard, S. A., Grayson, L. M., Johnson, P. D. R., Howden, B. P., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-595 · Cited by 66

Authors: Bonten, M. J., Willems, R., & Weinstein, R. A.
Affiliations: University Medical Center Utrecht (NL)
National Institute for Public Health and the Environment (NL)
John H. Stroger, Jr. Hospital of Cook County (US)
Corresponding author: Bonten, Marc JM
ORCID: Bonten, Marc JM
Willems, Rob
Weinstein, Robert A
Venue: The Lancet Infectious Diseases
Publisher: Elsevier BV
Published: 2001-12
Volume: 1
Issue: 5
Pages: 314-325
ISSN: 1473-3099 (ISSN-L)
DOI: 10.1016/s1473-3099(01)00145-1
OpenAlex: W1998796942
Cited by: 400
References: 104
Citations by year: 2026: 4 · 2025: 4 · 2024: 10 · 2023: 17 · 2022: 6 · 2021: 10 · 2020: 17 · 2019: 12 · 2018: 14 · 2017: 18 · 2016: 17 · 2015: 11 · 2014: 18 · 2013: 28 · 2012: 25
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Keywords: vancomycin-resistant enterococci, nosocomial infections, antibiotic resistance, avoparcin, reservoir hosts, human colonization, hospital outbreak, virulence genes, esp gene, resistance gene spread, antimicrobial use
MeSH terms: Animals, Animal Husbandry, Anti-Bacterial Agents, Bacterial Proteins, Cross Infection, Disease Outbreaks, Europe, Humans, Membrane Proteins, North America, Vancomycin, Gram-Positive Bacterial Infections, Enterococcus, Enterococcus faecium, Infection Control, Vancomycin Resistance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vancomycin-resistant enterococci: why are they here, and where do they come from?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks