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Tuberculosis and diabetes mellitus: convergence of two epidemics

Open access
Dooley, Kelly E, Chaisson, Richard E·2009·The Lancet Infectious Diseases

Abstract

The link between diabetes mellitus and tuberculosis has been recognised for centuries. In recent decades, tuberculosis incidence has declined in high-income countries, but incidence remains high in countries that have high rates of infection with HIV, high prevalence of malnutrition and crowded living conditions, or poor tuberculosis control infrastructure. At the same time, diabetes mellitus prevalence is soaring globally, fuelled by obesity. There is growing evidence that diabetes mellitus is an important risk factor for tuberculosis and might affect disease presentation and treatment response. Furthermore, tuberculosis might induce glucose intolerance and worsen glycaemic control in people with diabetes. We review the epidemiology of the tuberculosis and diabetes epidemics, and provide a synopsis of the evidence for the role of diabetes mellitus in susceptibility to, clinical presentation of, and response to treatment for tuberculosis. In addition, we review potential mechanisms by which diabetes mellitus can cause tuberculosis, the effects of tuberculosis on diabetic control, and pharmacokinetic issues related to the co-management of diabetes and tuberculosis.

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Metadata

Authors
Dooley, K. E., & Chaisson, R. E.
Venue
The Lancet Infectious Diseases
Publisher
Elsevier BV
Published
2009-12
Volume
9
Issue
12
Pages
737-746
ISSN
1473-3099 (ISSN-L)
OpenAlex
W2136564653
Cited by
932
References
4
FWCI
23.25
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Tuberculosis and diabetes mellitus: convergence of two epidemics. https://app.cochat.ai/papers/10.1016/s1473-3099(09)70282-8
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Dooley, K. E., & Chaisson, R. E. (2009). Tuberculosis and diabetes mellitus: convergence of two epidemics. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(09)70282-8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.