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Cited by 645Salmonella and Campylobacter epidemiologyBacterial Infections and VaccinesGlobal Health and Epidemiology

The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017

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Stanaway, Jeffrey D., Parisi, Andrea, Sarkar, Kaushik, Blacker, Brigette F., Reiner, Robert C, Hay, Simon I., Nixon, Molly R, Dolecek, Christiane +66 more·2019·The Lancet Infectious Diseases
DOI 10.1016/s1473-3099(19)30418-9PMC PMC6892270
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Abstract

BACKGROUND: Non-typhoidal salmonella invasive disease is a major cause of global morbidity and mortality. Malnourished children, those with recent malaria or sickle-cell anaemia, and adults with HIV infection are at particularly high risk of disease. We sought to estimate the burden of disease attributable to non-typhoidal salmonella invasive disease for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. METHODS: We did a systematic review of scientific databases and grey literature, and estimated non-typhoidal salmonella invasive disease incidence and mortality for the years 1990 to 2017, by age, sex, and geographical location using DisMod-MR, a Bayesian meta-regression tool. We estimated case fatality by age, HIV status, and sociodemographic development. We also calculated the HIV-attributable fraction and estimated health gap metrics, including disability-adjusted life-years (DALYs). FINDINGS: We estimated that 535 000 (95% uncertainty interval 409 000-705 000) cases of non-typhoidal salmonella invasive disease occurred in 2017, with the highest incidence in sub-Saharan Africa (34·5 [26·6-45·0] cases per 100 000 person-years) and in children younger than 5 years (34·3 [23·2-54·7] cases per 100 000 person-years). 77 500 (46 400-123 000) deaths were estimated in 2017, of which 18 400 (12 000-27 700) were attributable to HIV. The remaining 59 100 (33 300-98 100) deaths not attributable to HIV accounted for 4·26 million (2·38-7·38) DALYs in 2017. Mean all-age case fatality was 14·5% (9·2-21·1), with higher estimates among children younger than 5 years (13·5% [8·4-19·8]) and elderly people (51·2% [30·2-72·9] among those aged ≥70 years), people with HIV infection (41·8% [30·0-54·0]), and in areas of low sociodemographic development (eg, 15·8% [10·0-22·9] in sub-Saharan Africa). INTERPRETATION: We present the first global estimates of non-typhoidal salmonella invasive disease that have been produced as part of GBD 2017. Given the high disease burden, particularly in children, elderly people, and people with HIV infection, investigating the sources and transmission pathways of non-typhoidal salmonella invasive disease is crucial to implement effective preventive and control measures. FUNDING: Bill & Melinda Gates Foundation.

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  • Invasive non-typhoidal Salmonella accounts for 534,600 (409,000-705,000) cases and 77,470 (46,360-122,800) deaths annually worldwide; out of these, 421,600 (316,000-574,100) cases (26.2% attributed to HIV infection) and 66,520 deaths occur in sub-Saharan Africa.

    “iNTS accounts for 534,600 (409,000-705,000) cases and 77,470 (46,360-122,800) deaths annually worldwide; out of these, 421,600 (316,000-574,100) cases (26.2% attributed to HIV infection) and 66,520 deaths occur in SSA.87”

    From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [87]

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Authors
Stanaway, J. D., Parisi, A., Sarkar, K., Blacker, B. F., Reiner, R. C., Hay, S. I., Nixon, M. R., Dolecek, C., James, S. L., Mokdad, A. H., Abebe, G., Ahmadian, E., Alahdab, F., Alemnew, B. T. T., Alipour, V., Allah Bakeshei, F., Animut, M. D., Ansari, F., Arabloo, J., Asfaw, E. T., Bagherzadeh, M., Bassat, Q., Belayneh, Y. M. M., Carvalho, F., Daryani, A., Demeke, F. M., Demis, A. B. B., Dubey, M., Duken, E. E., Dunachie, S. J., Eftekhari, A., Fernandes, E., Fouladi Fard, R., Gedefaw, G. A., Geta, B., Gibney, K. B., Hasanzadeh, A., Hoang, C. L., Kasaeian, A., Khater, A., Kidanemariam, Z. T., Lakew, A. M., Malekzadeh, R., Melese, A., Mengistu, D. T., Mestrovic, T., Miazgowski, B., Mohammad, K. A., Mohammadian, M., Mohammadian-Hafshejani, A., Nguyen, C. T., Nguyen, L. H., Nguyen, S. H., Nirayo, Y. L., Olagunju, A. T., Olagunju, T. O., Pourjafar, H., Qorbani, M., Rabiee, M., Rabiee, N., Rafay, A., Rezapour, A., Samy, A. M., Sepanlou, S. G., Shaikh, M. A., Sharif, M., Shigematsu, M., Tessema, B., Tran, B. X., Ullah, I., Yimer, E. M., Zaidi, Z., Murray, C. J. L., & Crump, J. A.
Affiliations
University of Washington (US)
ORCID
Venue
The Lancet Infectious Diseases
Publisher
Elsevier BV
Published
2019-12
Volume
19
Issue
12
Pages
1312-1324
ISSN
1473-3099 (ISSN-L)
DOI
10.1016/s1473-3099(19)30418-9
PMC
PMC6892270
OpenAlex
W2975535544
Cited by
645
References
2
Citations by year
2026: 87 · 2025: 117 · 2024: 96 · 2023: 117 · 2022: 86 · 2021: 91 · 2020: 49 · 2019: 2
FWCI
43.99
Type
journal article
Language
en
Open access
Licence
Locations
  • The Lancet Infectious Diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • ANU Open Research (Australian National University) (submittedVersion, cc-by)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
Funders
  • Bill and Melinda Gates Foundation (OPP1132415)
  • National Health and Medical Research Council
  • Fundação para a Ciência e a Tecnologia
  • Ministério da Ciência, Tecnologia e Ensino Superior
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Health Sciences › Health Professions › Health Information Management › Global Health and Epidemiology
Keywords
non-typhoidal Salmonella, invasive Salmonella disease, global burden of disease, incidence and mortality, case fatality, disability-adjusted life years, malaria, sickle cell disease, children under five, sub-Saharan Africa, HIV infection, Global Burden of Disease Study 2017, risk factors
MeSH terms
Global Burden of Disease, Female, Humans, Male, Risk Factors, Salmonella, Salmonella Infections, Socioeconomic Factors, Incidence, Prevalence, Geography, Medical

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