PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

Sirima, Sodiomon B; Richert, Laura; Chêne, Arnaud; Konate, Amadou T; Campion, Cécilia; Dechavanne, Sébastien; Semblat, Jean-Philippe; Benhamouda, Nadine; Bahuaud, Mathilde; Loulergue, Pierre; Ouédraogo, Alphonse; Nébié, Issa; Kabore, Moïse; Kargougou, Désiré; Barry, Aïssata; Ouattara, San Maurice; Boilet, Valérie; Allais, Florence; Roguet, Gwenaelle; Havelange, Nicolas; Lopez-Perez, Elvira; Kuppers, Alexis; Konaté, Eleine; Roussillon, Caroline; Kanté, Myriam; Belarbi, Linda; Diarra, Amidou; Henry, Noelie; Soulama, Issiaka; Ouédraogo, Amidou; Esperou, Helene; Leroy, Odile; Batteux, Frederic; Tartour, Eric; Viebig, Nicola K; Thiebaut, Rodolphe; Launay, Odile; Gamain, Benoît

doi:10.1016/s1473-3099(19)30739-x

PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

BACKGROUND PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy. We assessed the safety and immunogenicity of PRIMVAC adjuvanted with Alhydrogel or glucopyranosyl lipid adjuvant in stable e…