The Enhanced Gonococcal Surveillance Programme, Cambodia

WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017–18: a retrospective observational study

Unemo, M., Lahra, M. M., Escher, M., Eremin, S., Cole, M. J., Galarza, P., Ndowa, F., Martin, I., Dillon, J.-A. R., Galas, M., et al. (2021) · The Lancet Microbe · doi:10.1016/s2666-5247(21)00171-3 · Cited by 272

Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022

Pleininger, S., Indra, A., Golparian, D., Heger, F., Schindler, S., Jacobsson, S., Heidler, S., & Unemo, M. (2022) · Eurosurveillance · doi:10.2807/1560-7917.es.2022.27.24.2200455 · Cited by 106

Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022

Day, M. J., Pitt, R., Mody, N., Saunders, J., Rai, R., Nori, A., Church, H., Mensforth, S., Corkin, H., Jones, J., et al. (2022) · Eurosurveillance · doi:10.2807/1560-7917.es.2022.27.46.2200803 · Cited by 91

Antimicrobial treatment and resistance in sexually transmitted bacterial infections

Jensen, J. S., & Unemo, M. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01023-3 · Cited by 139

Ceftriaxone-resistant Neisseria gonorrhoeae detected in England, 2015–24: an observational analysis

Fifer, H., Doumith, M., Rubinstein, L., Mitchell, L., Wallis, M., Singh, S., Singh, G. K. J., Rayment, M., Evans-Jones, J., Blume, A., et al. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae369 · Cited by 59

High prevalence of ceftriaxone-resistant and XDR Neisseria gonorrhoeae in several cities of Cambodia, 2022–23: WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP)

Ouk, V., Heng, L. S., Virak, M., Deng, S., Lahra, M. M., Frankson, R. M., Kreisel, K. M., McDonald, R., Escher, M., Unemo, M., et al. (2024) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlae053 · Cited by 52

Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

Maubaret, C., Caméléna, F., Mrimèche, M., Braille, A., Liberge, M., Mainardis, M., Guillaume, C., Noël, F., Bébéar, C., Molina, J., et al. (2023) · Eurosurveillance · doi:10.2807/1560-7917.es.2023.28.37.2300456 · Cited by 51

British Association of Sexual Health and HIV UK National Guideline for the Management of infection with Neisseria gonorrhoeae , 2025

Fifer, H., Ismail, M. A., Soni, S., Nwaosu, U., Sadiq, S. T., Milligan, A. L., Saunders, J., & Medland, N. (2025) · International Journal of STD & AIDS · doi:10.1177/09564624251345195 · Cited by 34

Ceftriaxone resistance in Neisseria gonorrhoeae associated with the penA-60.001 allele in Hanoi, Viet Nam

Adamson, P. C., Hiếu, V. N., Nhung, P. H., Whiley, D. M., & Chau, T. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00230-5 · Cited by 31

Surge in Ceftriaxone-Resistant Neisseria gonorrhoeae FC428-Like Strains, Asia-Pacific Region, 2015−2022

Xiu, L., Zhang, L., & Peng, J. (2024) · Emerging infectious diseases · doi:10.3201/eid3008.240139 · Cited by 29

Effects of doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections on gonorrhoea prevalence and antimicrobial resistance among men who have sex with men in the USA: a modelling study

Reichert, E. N., & Grad, Y. H. (2024) · The Lancet Microbe · doi:10.1016/s2666-5247(24)00168-x · Cited by 29

Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023

Caméléna, F., Mérimèche, M., Brousseau, J., Mainardis, M., Verger, P., Risbe, C. L., Brottet, É., Thabuis, A., Bébéar, C., Molina, J., et al. (2024) · Emerging infectious diseases · doi:10.3201/eid3009.240557 · Cited by 31

World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme, Cambodia, 2023

Ouk, V., Heng, L. S., Virak, M., Deng, S., Frankson, R. M., McDonald, R., Kersh, E. N., Wi, T., Maatouk, I., van Hal, S. J., et al. (2024) · Emerging infectious diseases · doi:10.3201/eid3007.240354 · Cited by 27

Managing treatment failure in Neisseria gonorrhoeae infection: current guidelines and future directions

Allan‐Blitz, L., Fifer, H., & Klausner, J. D. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00001-x · Cited by 26

The continuing evolution of antibiotic resistance in Neisseria gonorrhoeae: past, present and future threats to effective treatment

Fifer, H., & Johnson, A. P. (2025) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaf109 · Cited by 22

High-level ceftriaxone resistance due to transfer of penA allele 60.001 into endemic gonococcal lineages in Hangzhou, China

Yang, F., Sun, X., Fu, Y., Zhao, F., Lin, X., Chen, Y., & van der Veen, S. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae297 · Cited by 18

Emergence of an extensively drug-resistant Neisseria gonorrhoeae clone

van Hal, S. J., Sherry, N. L., Coombs, G. W., Mowlaboccus, S., Whiley, D. M., & Lahra, M. M. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00486-9 · Cited by 16

Pharmacodynamic evaluation of ceftriaxone single-dose therapy (0.125–1 g) to eradicate ceftriaxone-susceptible and ceftriaxone-resistant Neisseria gonorrhoeae strains in a hollow fibre infection model for gonorrhoea

Unemo, M., Golparian, D., Oxelbark, J., Kong, F. Y. S., Brown, D. L., Louie, A., Drusano, G. L., & Jacobsson, S. (2024) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkae063 · Cited by 15

Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against Neisseria gonorrhoeae infection in men who have sex with men: the GoGoVax study protocol

Seib, K. L., Donovan, B. J., Thng, C., Lewis, D. A., McNulty, A. M., Fairley, C. K., Yeung, B., Jin, F., Fraser, D., Bavinton, B. R., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-081675 · Cited by 14

Antimicrobial Resistance in Curable Sexually Transmitted Infections

Giacani, L., Bradshaw, C. S., Muzny, C. A., Graves, K. J., Pasricha, S., Jordan, S. J., & Allan‐Blitz, L. (2025) · Current HIV/AIDS Reports · doi:10.1007/s11904-025-00722-7 · Cited by 14

Determining targets for ceftriaxone resistance detection in Neisseria gonorrhoeae based on genotype–phenotype data: an observational study

van Hal, S. J., Lahra, M. M., & Whiley, D. M. (2025) · The Lancet Microbe · doi:10.1016/j.lanmic.2025.101199 · Cited by 9

Unnecessary antibiotic use in men who have sex with men (MSM) with anogenital symptoms attending a sexual health clinic: a retrospective analysis

Wong, A. K. C., Applegate, T. L., Boettiger, D. C., Varma, R., Guy, R., & Medland, N. (2024) · Sexually Transmitted Infections · doi:10.1136/sextrans-2024-056120 · Cited by 8

Emergence and evolution of mosaic penA-60 and penA-237 alleles in a Neisseria gonorrhoeae core genogroup that was historically susceptible to extended spectrum cephalosporins

Thomas, J. C., Cartee, J. C., Hebrank, K., Cyr, S. B. S., Schlanger, K., Raphael, B. H., Kersh, E. N., & Joseph, S. J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1401303 · Cited by 8

PenA Alleles Associated With Gonococcal Ceftriaxone Resistance in Cambodia, China, and Vietnam

van der Veen, S., Sun, X., Ge, H., Châu, T. M., Pham, H. N., Vandelannoote, K., Delvallez, G., Cheng, S., Laumen, J., & Adamson, P. C. (2025) · Clinical Infectious Diseases · doi:10.1093/cid/ciaf530 · Cited by 6

Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae

Anahtar, M. N., Valeri, J. A., Modaresi, S. M., Krishnan, A., Donghia, N. M., Palace, S. G., Zheng, E. J., Gulati, A., Jorgenson, A. C., Junaid, A., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.ads4699 · Cited by 5

2-Hydroxychalcone is a gonococcal-specific antimicrobial with activity against elongation factor Tu and butanediol dehydrogenase

Zhang, J., Yang, F., Sun, X., Gao, L., Yan, J., Chen, X., Gu, Y., Song, S., Hu, F., Lin, X., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123994 · Cited by 3

Ceftriaxone-resistant Neisseria gonorrhoeae detected in England, 2015 to 2024; an observational studyPreprint

Fifer, H., Doumith, M., Rubinstein, L., Mitchell, L., Wallis, M., Singh, S., Singh, G. K. J., Rayment, M., Evans-Jones, J., Blume, A., et al. (2024) · medRxiv · doi:10.1101/2024.08.12.24311674 · Cited by 3

Antimicrobial resistance crisis in STIs: Gonorrhea and M. genitalium on the brink of untreatability

Ghodsi, N., Arezoomand, R., & Azimian, A. (2026) · New Microbes and New Infections · doi:10.1016/j.nmni.2026.101747 · Cited by 2

Limitations of Global Surveillance for Neisseria gonorrhoeae Antimicrobial Resistance

van Hal, S. J., Fifer, H., & Lahra, M. M. (2026) · Emerging infectious diseases · doi:10.3201/eid3206.260378 · Cited by 2

Updated recommendations for the treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum (syphilis) and new recommendations on syphilis testing and partner services

World Health Organization (2024) · doi:10.2471/b09099 · Cited by 1

Genetic identification of mutations and MLST types associated with decreased susceptibility to ceftriaxone in Neisseria gonorrhoeae

Zhang, X., WANG, H., YiXin, G., Chen, X., Zhou, G., Liu, C., Ji, L., Xie, R., 张建中, Shao, Z., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1728860 · Cited by 1

A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae

Uehara, T., Zulli, A. L., Miller, B., Avery, L. M., Boyd, S. A., Chatwin, C. L., Chu, G., Drager, A. S., Edwards, M., Hart, S. G. E., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02309-3 · Cited by 1

Antimicrobial-Resistant Neisseria gonorrhoeae of Public Health Concern, New South Wales, Australia, 2022–2024

Walker, L. J., van Hal, S. J., Li, C., Nigro, S. J., Donnan, E., Ryder, N., Lahra, M. M., & Amin, J. (2026) · Emerging infectious diseases · doi:10.3201/eid3206.251399 · Cited by 1

Beyond Ceftriaxone: The Future of Gonorrhea Diagnosis and Treatment

Allan‐Blitz, L., & Klausner, J. D. (2026) · Clinical Infectious Diseases · doi:10.1093/cid/ciag214 · Cited by 1

Rapid expansion of penA allele 60.001-containing endemic ceftriaxone-resistant gonococcal ST8123 lineage in Hangzhou, China

Sun, X., Fu, Y., Zhao, F., Lin, X., Chen, Y., & van der Veen, S. (2026) · Infection · doi:10.1007/s15010-026-02889-6 · Cited by 1

Global, regional and local surveillance of antimicrobial resistance in Neisseria gonorrhoeae

Lahra, M. M., George, C., & van Hal, S. J. (2024) · Microbiology Australia · doi:10.1071/ma24038 · Cited by 1

Estimating the undetected burden and the likelihood of strain persistence of drug-resistant Neisseria gonorrhoeae

Roster, K. I. O., Rönn, M. M., Elder, H. R., Gift, T. L., Roosevelt, K. A., Salomon, J. A., Hsu, K., & Grad, Y. H. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae455 · Cited by 1

A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeaePreprint

Uehara, T., Zulli, A. L., Miller, B., Avery, L. M., Boyd, S. A., Chatwin, C. L., Chu, G., Drager, A. S., Edwards, M., Hart, S. G. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.27.630553 · Cited by 1

Australian Gonococcal Surveillance Program, 1 April to 30 June 2023

Lahra, M. M., van Hal, S. J., & Hogan, T. R. (2024) · Communicable Diseases Intelligence · doi:10.33321/cdi.2024.48.13

Estimating the undetected burden of infections and the likelihood of strain persistence of drug-resistant Neisseria gonorrhoeaePreprint

Roster, K. I. O., Rönn, M. M., Elder, H. R., Gift, T. L., Roosevelt, K. A., Salomon, J. A., Hsu, K., & Grad, Y. H. (2024) · medRxiv · doi:10.1101/2024.08.28.24312729

Updates bei der Behandlung von Gonokokken-Infektionen

Chromy, D. (2024) · hautnah · doi:10.1007/s12326-024-00682-6

Spread of Neisseria gonorrhoeae FC428 Subclone MLST ST13871

Li, H., Zhu, B.-Y., Gan, Q., Nguyen, T. T., & Chen, S.-C. (2024) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000159

Molecular Diagnosis of Sexually Transmitted Infection Reveals a High Frequency of Neisseria gonorrhoeae Infection among Male Urethritis Patients and Highlights the Usefulness of Molecular Testing for Clinical Diagnosis in Burkina Faso

Gomgnimbou, M. K., Da, A., Belem, L. R. W., Gnada, K., Yao, K. R., Sanou, A. Q., Sanou, A. M., Sanou, S., & Kania, D. (2025) · American Journal of Molecular Biology · doi:10.4236/ajmb.2025.151010

Antimicrobial activity of temocillin on ceftriaxone-resistant and ceftriaxone-susceptible isolates of Neisseria gonorrhoeae

Brousseau, J., Caméléna, F., Meunier, F., Boyd, A. C., Chiarabini, T., Surgers, L., & Berçot, B. (2025) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaf235

Epidemiology of gonococcal arthritis in Brittany - France (EpGAr study)

Lemoine, V., Rolland, S., Reissier, S., Paz, D. L., Souffez, M., Favalelli, M., Scavazzin, V., Brousseau, J., Lamoureux, C., Piau, C., et al. (2025) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2025.151692

Abolishing PorB-induced mitophagy enhances gonococcal outer membrane vesicle vaccine efficacy

Ge, H., Qin, Y., Song, S., Yuan, D., Gao, S., Lin, X., & van der Veen, S. (2026) · Emerging Microbes & Infections · doi:10.1080/22221751.2026.2651468

Antimicrobial susceptibility patterns of Neisseria gonorrhoeae across anatomical sites within and between individuals in the Netherlands: a retrospective observational study

Visser, M., Wolffs, P. F. G., Hoebe, C. J. P. A., BENTHEM, B. H. B. V., van Dam, A. P., Twisk, D. E., Dukers–Muijrers, N. H. T. M., Low, N. N., Unemo, M., & Heijne, J. C. M. (2026) · The Lancet Microbe · doi:10.1016/j.lanmic.2026.101381

Development of a Point-of-Care Recombinase Polymerase Amplification Assay for Detection of Neisseria gonorrhoeae and Ceftriaxone-Resistance Associated penA Allele 60.001

Sun, X., Fu, Y., Liu, Y., Liu, Q., Chen, L., Zhu, J., Lin, X., Cheng, H., & van der Veen, S. (2026) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-026-00868-z

Management of urogenital gonococcal infection

Oomeer, S. (2026) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2025.000038

Antimicrobial resistance in Neisseria gonorrhoeae isolates at the Bangrak STIs Center, Bangkok, Thailand and WGS of antimicrobial-resistant isolates, 2018–23

Paopang, P., Sangprasert, P., Golparian, D., Girdthep, N., Jintana, N., Sonnak, S., Sangsuk, P., Bunpan, T., Unemo, M., & Kittiyaowamarn, R. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag260

In vitro carbapenem activity in Neisseria gonorrhoeae

Brousseau, J., Braille, A., Mainardis, M., Meunier, F., Mérimèche, M., Caméléna, F., & Berçot, B. (2026) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlag201

Novel potential treatment options for infections caused by multi-drug and extensively drug-resistant Neisseria gonorrhoeae strains

Jacobsson, S., & Unemo, M. (2026) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2026.2733617 · Cited by 1

A One Health Scoping Review of Antimicrobial Resistance in Cambodia: Evidence Mapping and Insights into Klebsiella pneumoniae

Puth, S., Chhoung, C., Hav, L., Rin, C., Seang, K., Sagaon‐Teyssier, L., & Saphonn, V. (2026) · Microorganisms · doi:10.3390/microorganisms14102161

Activity of the novel oral antimicrobials zoliflodacin and gepotidacin against ceftriaxone-resistant and/or multidrug-resistant Neisseria gonorrhoeae isolates from Hangzhou, China

Lu, W., Fu, Y., Lin, X., Rao, Y., Unemo, M., & van der Veen, S. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag330

Tigecycline displays bactericidal activity against multidrug-resistant Neisseria gonorrhoeae and enhances clearance from a mouse infection model

Sun, X., Lu, W., Ge, H., Qin, Y., Yuan, D., Lin, X., Rao, Y., & van der Veen, S. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag337

Gamifying Strategies for Treatment Diversification in Gonorrhea: A Potential Novel Education Tool (Preprint)Preprint

Xie, K., Garcia, C. Y., Harris, S., Chou, C., Klausner, J. D., & Allan‐Blitz, L. (2026) · doi:10.2196/preprints.115233

Trends in Gonococcal Antimicrobial Resistance in Cameroon: Before and After the Launching of the Gonococcal Antimicrobial Surveillance Program

Nzouankeu, A., Ngandjio, A., Tayimetha, C. Y., Tchouwa, G. F., Abanda, M., Sokeng, E., & Fonkoua, M. (2016) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2016.512.020

The WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) identifies high levels of ceftriaxone resistance across Vietnam, 2023

Lan, P. T., Nguyen, H. T., Golparian, D., Vân, N. T. T., Maatouk, I., Unemo, M., Doanh, L. H., Lan, P. T., Pham, H. Q., Hoa, P. D., et al. (2024) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2024.101125 · Cited by 28

World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme, Cambodia, 2023

Ouk, V., Heng, L. S., Virak, M., Deng, S., Frankson, R. M., McDonald, R., Kersh, E. N., Wi, T., Maatouk, I., van Hal, S. J., et al. (2024) · Emerging infectious diseases · doi:10.3201/eid3007.240354 · Cited by 27

High prevalence of ceftriaxone-resistant and XDR Neisseria gonorrhoeae in several cities of Cambodia, 2022–23: WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP)

Ouk, V., Heng, L. S., Virak, M., Deng, S., Lahra, M. M., Frankson, R. M., Kreisel, K. M., McDonald, R., Escher, M., Unemo, M., et al. (2024) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlae053 · Cited by 52

P641 Gonococcal antimicrobial susceptibility from the thailand enhanced gonococcal antimicrobial surveillance program, 2015–2018

Sirivongrangson, P., Girdthep, N., Buasakul, P., Daengsaard, E., Kittiyaowamarn, R., Cherdtrakulkiat, T., Tongtoyai, J., Tatakham, N., Duangdee, C., Dunne, E. F., et al. (2019) · Poster presentations · doi:10.1136/sextrans-2019-sti.709