Non-autonomous cell death in Parkinson's disease
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Non-cell autonomous mechanisms can cause dysfunction across the entire substantia nigra pars compacta, leading to rapid dopaminergic neurodegeneration, in contrast to neuron-specific cell autonomous mechanisms.
“in contrast to neuron-specific cell autonomous mechanisms that affect individual DA neurons within the SNc, non-cell autonomous mechanisms can cause dysfunction across the entire SNc, thereby leading to rapid DA neurodegeneration”
From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Dawson 2008
Cites
Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · see citing works
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Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation
Matheoud, D., Sugiura, A., Bellemare-Pelletier, A., Laplante, A., Rondeau, C., Chemali, M., Fazel, A., Bergeron, J. J., Trudeau, L.-E., Burelle, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.039 · Cited by 582 · see citing works
Ayala, D. A., Hall, G. M., Das, D., Tijerina, E., Villagran, L. L., Khan, Z., Paliwal, D., Anand, A., Rimer, M., & Srinivasan, R. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01713-x · Cited by 1 · see citing works
- Authors
- Dawson, T. M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Dawson, Ted M
- ORCID
- Dawson, Ted M
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 7
- Issue
- 6
- Pages
- 474-475
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC4505358
- OpenAlex
- W1969139816
- Cited by
- 16
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 2 · 2019: 3 · 2016: 2 · 2014: 1 · 2012: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (P50NS038377)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Parkinson's disease, dopamine neuron loss, alpha-synuclein aggregation, Lewy bodies, neurodegeneration
- MeSH terms
- Animals, Encephalitis, Gliosis, Graft Survival, Humans, Nerve Degeneration, Neurons, Parkinson Disease, Substantia Nigra, Fetal Tissue Transplantation, Brain Tissue Transplantation, Lewy Bodies, Cell Death, Microglia, Mice, alpha-Synuclein
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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