Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes

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1. Sex differences in the utilization and outcomes of endovascular treatment after acute ischemic stroke: A systematic review and meta-analysis
   Menglu Ouyang, Sultana Shajahan, Xiaoying Liu, Lingli Sun, Cheryl Carcel, Katie Harris, Craig S. Anderson, Mark Woodward, Xia Wang · 2023 · Frontiers in Global Women s Health
2. Persistent Sex Disparity in Midlife Stroke Prevalence in the United States
   Amytis Towfighi, Daniela Markovic, Bruce I Ovbiagele · 2011 · Cerebrovascular Diseases
3. Stroke and active life expectancy in the United States, 1999–2009
   James N. Laditka, Sarah B. Laditka · 2014 · Disability and health journal
4. Epidemiology, Risk Factors, and Outcomes of Out-of-Hospital Cardiac Arrest Caused by Stroke
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5. Sex and Stroke in Thrombolyzed Patients and Controls
   Christian Hametner, Rachael L. Macisaac, Lars Kellert, Azmil H. Abdul‐Rahim, Peter Arthur Ringleb, Kennedy R. Lees, Andrei V. Alexandrov, Philip M. Bath, E. Bluhmki, Natan M. Bornstein et al. · 2016 · Stroke
6. Sex Differences in Epidemiology of Cardiac and Vascular Disease
   Tatiana Kuznetsova · 2018 · Advances in experimental medicine and biology
7. Socioeconomic and Cardiovascular Variables Explaining Regional Variations in Stroke Mortality in Chile: An Ecological Study
   Pablo M. Lavados, Violeta Díaz, Liliana Jadue H, Verónica V. Olavarría, Daniel A. Cárcamo, Iris Delgado · 2011 · Neuroepidemiology
8. International Classification of Functioning, Disability, and Health-based rehabilitation program promotes activity and participation of post-stroke patients
   Mabel Ngai-Kiu Wong, Mike Kwun-Ting Cheung, Yuk-Mun Ng, Huan-Ling Yuan, Bess Yin‐Hung Lam, Siu Ngor Fu, Chetwyn C. H. Chan · 2023 · Frontiers in Neurology
9. Sex differences in age-associated neurological diseases—A roadmap for reliable and high-yield research
   Anna Katharina Bonkhoff, Gillian Coughlan, Valentina Perosa, Kenda Alhadid, Markus D. Schirmer, Robert William Regenhardt, Susanne J. van Veluw, Rachel F. Buckley, Michael Fox, Natalia S. Rost · 2025 · Science Advances
10. Sex differences in the genetic regulation of the human plasma proteome
    Mine Koprulu, Eleanor Wheeler, Nicola D. Kerrison, Spiros Denaxas, Julia Carrasco-Zanini, Chloe M. Orkin, Harry Hemingway, Nicholas J. Wareham, Maik Pietzner, Claudia Langenberg · 2025 · Nature Communications
11. Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
    Ya Ping Zhang, Shujun Gu, Cuicui Wang, Dong Liu, Qiuyi Zhang, Man Gil Yang, Zhengyuan Zhou, Hui Zuo · 2021 · BMJ Open
12. Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study
    Ilaria Casetta, Enrico Fainardi, Giovanni Pracucci, Valentina Saia, Fabrizio Sallustio, Valerio Da Ros, Sergio Nappini, Patrizia Nencini, Guido Bigliardi, Sergio Lucio Vinci et al. · 2022 · European Stroke Journal
13. Exposure to air pollution and its effect on ischemic strokes (EP-PARTICLES study)
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14. Risk factors related to early neurological deterioration in lacunar stroke and its influence on functional outcome
    Changhong Tan, Lili Zhao, Chengcheng Dai, Yi Liang, Hang Liu, Yuke Zhong, Guohui Liu, Lijuan Mo, Fen Den, Xi Liu et al. · 2022 · International Journal of Stroke
15. Female Enrollment in Rehabilitation Trials: A Systematic Review of Reporting Sex and Female Participation in Randomized Controlled Trials of Poststroke Upper Extremity Rehabilitation Over 50 Years
    Sarvenaz Mehrabi, Amber Harnett, Marcus Saikaley, Jamie L Fleet, Janice Jennifer Eng, Mark Theodore Bayley, Robert William Teasell · 2024 · Archives of Physical Medicine and Rehabilitation
16. Frailty Related Factors as Predictors of Functional Recovery in Geriatric Rehabilitation: The Sarcopenia and Function in Aging Rehabilitation (SAFARI) Multi-Centric Study
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17. Cognitive heterogeneity among community-dwelling older adults with cerebral small vessel disease
    Ayan Dey, Vess Stamenova, Agnes Bacopulos, Nivethika Jeyakumar, Gary R. Turner, Sandra E. Black, Brian Levine · 2019 · Neurobiology of Aging
18. Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study
    Wael Eldahshan, Tauheed Ishrat, Bindu A. Pillai, Mohammed A. Sayed, Abdulrahman M. Alwhaibi, Abdelrahman Y. Fouda, Adviye Ergul, Susan C. Fagan · 2019 · American Journal of Physiology-Heart and Circulatory Physiology
19. Clinical features of arterial hypertension in men and women (according to the National Registry of Arterial Hypertension)
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20. Healthy and unhealthy plant-based diets and the risk of cardiovascular diseases: The Rotterdam study and updated meta-analysis
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21. Disparities in Access to, Use of, and Quality of Rehabilitation After Stroke in the United States: A Scoping Review
    Janet K. Freburger, Elizabeth R. Mormer, Kristin Ressel, Shuqi Zhang, Anna M. Johnson, Amy M. Pastva, Rose L. Turner, Peter C. Coyle, Cheryl Bushnell, Pamela Woods Duncan et al. · 2024 · Archives of Physical Medicine and Rehabilitation
22. Changes of metabolic syndrome status alter the risks of cardiovascular diseases, stroke and all cause mortality
    Junzhen Li, Wenwen Liu, Hang Li, Xujun Ye, Juan‐Juan Qin · 2025 · Scientific Reports
23. Men Lacking a Caregiver Have Greater Risk of Long‐Term Nursing Home Placement After Stroke
    Justin L. Blackburn, Karen C. Albright, William E. Haley, Virginia J. Howard, David L. Roth, Monika M. Safford, Meredith L. Kilgore · 2017 · Journal of the American Geriatrics Society
24. Plasma Estradiol and Testosterone Levels and Ischemic Stroke in Postmenopausal Women
    Jie Hu, Jennifer Lin, Monik C. Jiménez, JoAnn E. Manson, Susan E. Hankinson, Kathryn M. Rexrode · 2020 · Stroke
25. Mir363-3p Treatment Attenuates Long-Term Cognitive Deficits Precipitated by an Ischemic Stroke in Middle-Aged Female Rats
    Aditya Panta, Karienn S. Montgomery, Marissa Nicolas, Kathiresh Kumar Mani, Dayalan Sampath, Farida Sohrabji · 2020 · Frontiers in Aging Neuroscience
26. Sex Differences in Causes of Death After Stroke: Evidence from a National, Prospective Registry
    Hoang Phan, Seana Gall, Christopher Leigh Blizzard, Natasha Anne Lannin, Amanda Gay Thrift, Craig S. Anderson, Joosup Kim, Rohan Grimley, Helen C. Castley, Monique F. Kilkenny et al. · 2020 · Journal of Women s Health
27. Sex Differences in Collateral Circulation and Outcome After Mechanical Thrombectomy in Acute Ischemic Stroke
    Christian Lagebrant, Birgitta Ramgren, Ashkan Hassani Espili, Antonio Marañon, Christine Kremer · 2022 · Frontiers in Neurology
28. Stress hyperglycemia as a modifiable predictor of futile recanalization in patients undergoing mechanical thrombectomy for acute ischemic stroke
    Giovanni Merlino, Sara Pez, Roberto Sartor, Fedra Kuris, Yan Tereshko, Lorenzo Nesi, Simone Lorenzut, Francesco Janes, Massimo Sponza, Vladimir Gavrilovic et al. · 2023 · Frontiers in Neurology
29. Who, why and when: stroke care unit patients seen by a palliative care service within a large metropolitan teaching hospital
    Peter Eastman, Gillian McCarthy, Caroline Anne Brand, Louise C Weir, Alexandra Gorelik, Brian Huong Canh Le · 2013 · BMJ Supportive & Palliative Care
30. Association between carotid intima‐media thickness and fasting blood glucose level: A population‐based cross‐sectional study among low‐income adults in rural China
    Liu Gao, Lingling Bai, Min Shi, Jingxian Ni, Hongyan Lu, Yanan Wu, Jun Tu, Xianjia Ning, Jinghua Wang, Yukun Li · 2017 · Journal of Diabetes Investigation
31. Stroke Rehabilitation and Risk of Mortality: A Population-Based Cohort Study Stratified by Age and Gender
    Wen‐Hsuan Hou, Cheng‐Hua Ni, Chung‐Yi Li, Pei-Shan Tsai, Li‐Fong Lin, Hsiu-Nien Shen · 2015 · Journal of Stroke and Cerebrovascular Diseases
32. Follow-up study on mortality in Korean stroke patients
    Jeehye Im, Kunsei Lee, K. Kim, N. Hong, Sang-Woon Lee, H. Bae · 2011 · Journal of Korean Medical Association
33. Exploring threats to generalisability in a large international rehabilitation trial (AVERT)
    Julie A Bernhardt, Audrey Raffelt, Leonid P. Churilov, Richard I. Lindley, Sally Speare, Jacqueline Ancliffe, Nur Ayub Md Ali, Shahul Hameed, Sheila Lennon, Anna McRae et al. · 2015 · BMJ Open
34. The outcomes of statin therapy in patients with acute ischemic stroke in Taiwan: a nationwide epidemiologic study
    H -C Lin, Jr‐Rung Lin, W -C Tsai, Cheng‐Hsien Lu, W -N Chang, C -C Huang, H -C Wang, C -T Kung, C -M Su, Yu‐Jih Su et al. · 2019 · QJM
35. Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study
    Tiberiu A. Pana, Mamas A. Mamas, Nicholas J. Wareham, Kay‐Tee Khaw, Dana K. Dawson, Phyo Kyaw Myint · 2023 · European Journal of Preventive Cardiology
36. Trends in Demographic and Geographic Disparities in Stroke Mortality Among Older Adults in the United States
    Martin G. McCandless, Andrew Y. Powers, Katherine E. Baker, Allison E. Strickland · 2024 · World Neurosurgery
37. Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling
    Soomin Jeong, Anil Kiran Chokkalla, Charles Kozhikkadan Davis, Hyunmook Jeong, Bharath Chelluboina, Vijay Kumar Arruri, Bori R. Kim, Ashlyn Narman, Saivenkateshkomal Bathula, Thiruma Valavan Arumugam et al. · 2024 · Stroke
38. Sex Differences in Stroke Rehabilitation Care in Alberta
    Eric F. Tanlaka, Kathryn M. King‐Shier, Theresa Green, Cydnee Seneviratne, Sean Peter Dukelow · 2020 · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
39. Sex differences in vascular risk factors, in‐hospital management, and outcomes of patients with acute ischemic stroke in China
    Hongqiu Gu, Chun‐Juan Wang, Xin Yang, Chelsea Liu, Xia Wang, Xingquan Zhao, Yilong Wang, Liping Liu, Xia Meng, Yong Jiang et al. · 2021 · European Journal of Neurology
40. Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction
    Feiwen Liu, Changcheng Chen, Wenjun Hong, Zhongfei Bai, Sizhong Wang, Hanna Lu, Qixiang Lin, Zhiyong Zhao, Chaozheng Tang · 2022 · CNS Neuroscience & Therapeutics
41. Poststroke Disability: Association Between Sex and Patient-Reported Outcomes
    Lara Carvalho de Oliveira, Ana Ponciano, Carissa Tuozzo, Anand Viswanathan, Natalia S. Rost, Mark R. Etherton · 2023 · Stroke
42. Association between homocysteine and incidence of ischemic stroke in subjects with essential hypertension: A matched case-control study
    Changyi Wang, Liyuan Han, Qunhong Wu, Renjie Zhuo, Kui Liu, Jinshun Zhao, Lina Zhang, Yanhua Hao, Rui Fan, Yanfen Liu et al. · 2015 · Clinical and Experimental Hypertension
43. Gender based differences in acute stroke care in Michigan hospitals
    Nandakumar Nagaraja, Pratik D. Bhattacharya, Flicia Mada, Leeza Salowich‐Palm, Sabrina Hinton, Scott R. Millis, Sam R. Watson, Seemant Chaturvedi, Kumar Rajamani · 2011 · Journal of the Neurological Sciences
44. Migrainous Infarction: Aspects on Risk Factors and Therapy
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45. Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
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46. Factors Mediating Outcome After Stroke: Gender, Thrombolysis, and Their Interaction
    Seung‐Jae Lee, Sung Hyuk Heo, Walter T. Ambrosius, Cheryl Bushnell · 2017 · Translational Stroke Research
47. Sex differences in neurological disorders: Insights from ischemic stroke, Parkinson’s disease, and multiple sclerosis
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48. Sex differences in long-term outcomes among acute ischemic stroke patients with diabetes in China
    Wenjuan Zhao, Zhongping An, Yan Hong, Guanen Zhou, Bin liu, Jingjing Guo, Yuanju Yang, Xianjia Ning, Jinghua Wang · 2015 · Biology of Sex Differences
49. Obstructive sleep apnea treatment disparities among older adults with neurological disorders
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50. Comorbidities associated with different levels of total cholesterol in male and female acute ischemic stroke patients
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51. Oxidative Stress Status in Post Stroke Patients: Sex Differences
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52. Novel Mechanisms and Therapeutic Targets for Ischemic Stroke: A Focus on Gut Microbiota
    Zeyu Bao, Zeyu Zhang, Guoyang Zhou, Anke Zhang, Anwen Shao, Feng Zhou · 2022 · Frontiers in Cellular Neuroscience
53. GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner
    Yifan Xu, Wenri H. Zhang, Elyse M. Allen, Lev M. Fedorov, Anthony Paul Barnes, Zu Yuan Qian, Thierno Madjou Bah, Yuandong Li, Ruikang K. Wang, Robert E. Shangraw et al. · 2022 · Translational Stroke Research
54. Stroke in Women
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55. Impact of gender–age interaction on the outcome of ischemic stroke in an Italian cohort of patients treated according to a standardized clinical pathway
    Licia Denti, Andrea Artoni, Umberto Scoditti, Caterina Caminiti, Fabiola Giambanco, Monica Casella, Gian Paolo Ceda · 2013 · European Journal of Internal Medicine
56. Sex Differences in Biological Markers of Health in the Study of Stress, Aging and Health in Russia
    Anna Oksuzyan, Maria A Shkolnikova, James W. Vaupel, Kaare Christensen, Владимир Михайлович Школьников · 2015 · PLoS ONE
57. Absolute risk and risk factors for stroke mortality in patients with end-stage kidney disease (ESKD): population-based cohort study using data linkage
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58. Qualidade de vida em pacientes com Acidente Vascular Cerebral
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59. Female survival advantage relates to male inferiority rather than female superiority: A hypothesis based on the impact of age and stroke severity on 1-week to 1-year case fatality in 40,155 men and women
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60. Antiplatelet treatment in primary and secondary stroke prevention in women
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61. Sevoflurane prevents stroke‐induced depressive and anxiety behaviors by promoting cannabinoid receptor subtype I‐dependent interaction between β‐arrestin 2 and extracellular signal‐regulated kinases 1/2 in the rat hippocampus
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62. Diseases that precede disability among latter-stage elderly individuals in Japan
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63. Dehydroepiandrosterone protects male and female hippocampal neurons and neuroblastoma cells from glucose deprivation
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64. Gender and thrombolysis therapy in acute ischemic stroke patients with incidence of obesity
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65. Sex Differences in Functional Capacity in Older Adults With Stroke: An Analysis of Data From the National Health and Aging Trends Study
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66. Post-stroke brain can be protected by modulating the lncRNA FosDT
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67. Post-stroke dysphagia: Neurological regulation and recovery strategies
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68. Gender and Quality of Life After Cerebral Stroke
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69. Sex Differences in the Presentation, Care, and Outcomes of Transient Ischemic Attack
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70. Disease-directed engineering for physiology-driven treatment interventions in neurological disorders
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71. Knowledge on the action to be taken and recognition of symptoms of stroke in a community: findings from the May Measurement Month 2017 blood pressure screening Programme in Malaysia
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72. Sex Differences Among Participants in the Latin American Stroke Registry
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73. Effect of sex differences on prognosis of intravenous thrombolysis: data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China)
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74. Gender Difference in the Interaction Effects of Diabetes and Hypertension on Stroke among the Elderly in the Shih-Pai Study, Taiwan
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75. Recognizing and Responding to Symptoms of Acute Coronary Syndromes and Stroke in Women
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76. Gender-Specific Predictors of Functional Outcome after Stroke Rehabilitation: Potential Role of the Autonomic Nervous System
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77. Changes in cerebral autoregulation in the second half of pregnancy and compared to non-pregnant controls
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78. Partial MHC class II constructs as novel immunomodulatory therapy for stroke
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79. The confounding issue of sex and stroke
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80. Simultaneous cardiocerebral infarctions: a five-year retrospective case series reviewing natural history
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81. Sex differences in outcomes of transcatheter edge‐to‐edge repair with MitraClip: A meta‐analysis
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82. Sex‐Associated Metabolites and Incident Stroke, Incident Coronary Heart Disease, Hypertension, and Chronic Kidney Disease in the REGARDS Cohort
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83. Differences in stroke clinical presentation among sexes
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84. Sex Differences in Stroke Incidence and Survival in Hong Kong, 2000–2007
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85. Sex-Specific Temporal Trends in In-Hospital Mortality After Stroke Among Middle-Age Individuals in the United States
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86. Multiple exposures to environmental pollutants and oxidative stress: Is there a sex specific risk of developmental complications for fetuses?
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87. Level of Activity Daily Living in Post Stroke Patients
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88. Sex-Based Differences in Symptom Perception and Care-Seeking Behavior in Acute Stroke
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89. Intracranial Vertebrobasilar Calcification in Patients with Ischemic Stroke Is a Predictor of Recurrent Stroke, Vascular Disease, and Death: A Case-Control Study
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90. Different predictors after stroke depending on functional dependency at discharge: a 5-year follow up study
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91. Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus
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92. Gender Imbalances Induced by Age Limits in Stroke Trials
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93. G894T endothelial nitric oxide synthase polymorphism and ischemic stroke in Morocco
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94. Women on hemodialysis have lower self-reported health-related quality of life scores but better survival than men
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95. Emergency Department Arrival Times, Treatment, and Functional Recovery in Women with Acute Ischemic Stroke
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96. Recent Patterns of Sex-Specific Midlife Stroke Hospitalization Rates in the United States
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97. Gender Differences in Acute Stroke Treatment
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98. Sex Differences of Combined Effects Between Hypertension and General or Central Obesity on Ischemic Stroke in a Middle-Aged and Elderly Population
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99. Sex differences in the risk of recurrent ischemic stroke after ischemic stroke and transient ischemic attack
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100. Rate of perceived stability as a measure of balance exercise intensity in people post-stroke
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