Role of microRNA in liver regeneration
Abstract
Background Liver regeneration is a complex process. microRNAs (miRNAs) are short, single-stranded RNAs that modify gene expression at the post-transcriptional level. Recent investigations have revealed that miRNAs are closely linked to liver regeneration. Data sources All included studies were obtained from PubMed, Embase, the ScienceDirect databases and Web of Science, with no limitation on publication year. Only studies published in English were considered. Results We grouped studies that involved miRNA and liver regeneration into two groups: miRNAs as promoters and as inhibitors of liver regeneration. We summarized the relevant miRNAs separately from the related pathways. Conclusions Blocking or stimulating the pathways of miRNAs in liver regeneration may be novel therapeutic strategies in future regeneration-related liver managements. We may discover additional chemotherapy targets of miRNA.
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Several microRNAs are involved in controlling hepatocyte regenerative identity, for example, by maintaining the hepatocyte quiescent state or promoting cell cycle entry during liver regeneration.
“As reviewed elsewhere,64,65 several microRNAs are involved in controlling hepatocyte regenerative identity, for example, by maintaining the hepatocyte quiescent state or promoting cell cycle entry during liver regeneration.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [65]
Cites
Meng, F., Henson, R., Lang, M., Wehbe, H., Maheshwari, S., Mendell, J. T., Jiang, J., Schmittgen, T. D., & Patel, T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.057 · Cited by 984 · see citing works
The ???small for size??? liver syndrome
Tucker, O. N., & Heaton, N. (2005) · Current Opinion in Critical Care · doi:10.1097/01.ccx.0000157080.11117.45 · Cited by 180 · see citing works
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Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
- Authors
- Yi, P.-S., Zhang, M., & Xu, M.-Q.
- Affiliations
- Sichuan University (CN)
- ORCID
- Zhang, Ming
- Venue
- Hepatobiliary & Pancreatic Diseases International
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 15
- Issue
- 2
- Pages
- 141-146
- ISSN
- 2352-9377 (ISSN-L)
- 1499-3872
- OpenAlex
- W2335138159
- Cited by
- 36
- References
- 2
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 2 · 2013: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatobiliary & pancreatic diseases international (publishedVersion)
- PubMed (publishedVersion)
- Hepatobiliary & pancreatic diseases international
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- microRNA, liver regeneration, post-transcriptional regulation, miRNA promoters, miRNA inhibitors, therapeutic target, chemotherapeutic target
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Liver, Liver Regeneration, Signal Transduction, MicroRNAs, Cell Proliferation
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