306. Generating Novel AAV Capsid Mutants for Large Genome Packaging Through Protein Libraries and Directed Evolution
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Protein libraries and directed evolution are being combined in an effort to generate novel AAVs endowed with larger packaging ability.
“Similarly, protein libraries and directed evolution are being combined in an effort to generate novel AAVs endowed with larger packaging ability [133].”
From Circumventing the packaging limit of AAV-mediated gene replacement therapy for neurological disorders (2022) · cites this paper as [133]
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Adeno-Associated Viral Vectors as a Tool for Large Gene Delivery to the Retina
Trapani, I. (2019) · Genes · doi:10.3390/genes10040287 · Cited by 73 · see citing works
Marrone, L., Marchi, P. M., & Azzouz, M. (2022) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2012148 · Cited by 56 · see citing works
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 22
- Pages
- S118
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W4230324531
- Cited by
- 2
- References
- 0
- Citations by year
- 2021: 1 · 2019: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- adeno-associated virus, protein libraries, directed evolution, viral vector design
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