The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Control of Skeletal Patterning by EphrinB1-EphB Interactions
Open accessAbstract
We report that targeted inactivation of the Eph receptor ligand ephrinB1 in mouse caused perinatal lethality, edema, defective body wall closure, and skeletal abnormalities. In the thorax, sternocostal connections were arranged asymmetrically and sternebrae were fused, defects that were phenocopied in EphB2/EphB3 receptor mutants. In the wrist, loss of ephrinB1 led to abnormal cartilage segmentation and the formation of additional skeletal elements. We conclude that ephrinB1 and B class Eph receptors provide positional cues required for the normal morphogenesis of skeletal elements. Another malformation, preaxial polydactyly, was exclusively seen in heterozygous females in which expression of the X-linked ephrinB1 gene was mosaic, so that ectopic EphB-ephrinB1 interactions led to restricted cell movements and the bifurcation of digital rays. Our findings suggest that differential cell adhesion and sorting might be relevant for an unusual class of X-linked human genetic disorders, in which heterozygous females show more severe phenotypes than hemizygous males.
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“In the female, random X-inactivation generates groups of cells that either express, or do not express ephrin-B1, and the homophilic sorting process increases the patch size of these cells, causing abnormal tissue boundaries (for example, in the coronal sutures and limbs).33”
From Craniosynostosis (2011) · cites this paper as [33]
Citations
Cites
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Mechanisms and functions of eph and ephrin signalling
Kullander, K., & Klein, R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm856 · Cited by 1,158
Self-citationBatlle, E., Henderson, J. T., Beghtel, H., van den Born, M., Sancho, E., Huls, G. A., Meeldijk, J., Robertson, J. V., van de Wetering, M., Pawson, T. J., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01015-2 · Cited by 1,154
Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
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Self-citationX-chromosome inactivation: counting, choice and initiation
Avner, P. R., & Heard, É. (2001) · Nature Reviews Genetics · doi:10.1038/35047580 · Cited by 700
Multiple roles of eph receptors and ephrins in neural development
Wilkinson, D. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058515 · Cited by 614
A Morphogenetic Approach to the Origin and Basic Organization of the Tetrapod Limb
Shubin, N. H., & Alberch, P. (1986) · Springer eBooks · doi:10.1007/978-1-4615-6983-1_6 · Cited by 591
Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System
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Self-citationEph receptors and ephrins restrict cell intermingling and communication
Mellitzer, G., Xu, Q., & Wilkinson, D. G. (1999) · Nature · doi:10.1038/21907 · Cited by 474
In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
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Eph receptor signalling casts a wide net on cell behaviour
Pasquale, E. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1662 · Cited by 1,013
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777
Signaling and transcriptional regulation in osteoblast commitment and differentiation
Huang, W. (2007) · Frontiers in bioscience · doi:10.2741/2296 · Cited by 662
Mechanisms of ephrin–Eph signalling in development, physiology and disease
Kania, A., & Klein, R. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.16 · Cited by 645
Self-citationOsteoimmunology: Interactions of the Bone and Immune System
Lorenzo, J., Horowitz, M. C., & Choi, Y. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0038 · Cited by 576
Metadata
- Authors
- Compagni, A., Logan, M., Klein, R., & Adams, R. H.
- Affiliations
- Cancer Research UK (GB)
- Max Planck Society (DE)
- Corresponding author
- Adams, Ralf H.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 5
- Issue
- 2
- Pages
- 217-230
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2014781971
- Cited by
- 231
- References
- 27
- Citations by year
- 2025: 3 · 2024: 9 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 13 · 2017: 7 · 2016: 12 · 2015: 9 · 2014: 6 · 2013: 16 · 2012: 12
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
- Keywords
- ephrin-B1, EphB receptors, EphB2, EphB3, skeletal patterning, cartilage segmentation, preaxial polydactyly, X-linked disorders, positional cues, cell adhesion, cell sorting, heterozygous females, perinatal lethality, mouse mutants
- MeSH terms
- Congenital Abnormalities, Animals, Embryo, Mammalian, Female, Humans, Male, Morphogenesis, Phenotype, Skeleton, Sternum, Signal Transduction, In Situ Hybridization, Gene Targeting, Body Patterning, Receptors, Eph Family, Receptor, EphB2, Ephrin-B1, Mice
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