Spatial Regulation of Developmental Signaling by a Serpin
Open accessAbstract
An extracellular serine protease cascade generates the ligand that activates the Toll signaling pathway to establish dorsoventral polarity in the Drosophila embryo. We show here that this cascade is regulated by a serpin-type serine protease inhibitor, which plays an essential role in confining Toll signaling to the ventral side of the embryo. This role is strikingly analogous to the function of the mammalian serpin antithrombin in localizing the blood-clotting cascade, suggesting that serpin inhibition of protease activity may be a general mechanism for achieving spatial control in diverse biological processes.
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The gradient of active Spatzle is further shaped through the action of a serpin, Spn27A.
“the gradient of active Spz is further shaped through the action of a serpin (serine-protease inhibitor), Spn27A”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Hashimoto et al. 2003
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Graded dorsal and differential gene regulation in the Drosophila embryo.
Reeves, G. T., & Stathopoulos, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000836 · Cited by 119 · see citing works
- Authors
- Hashimoto, C., Kim, D. R., Weiss, L. A., Miller, J. W., & Morisato, D.
- Affiliations
- Yale University (US)
- The Evergreen State College (US)
- Corresponding author
- Hashimoto, Carl
- ORCID
- Weiss, Linnea A
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 5
- Issue
- 6
- Pages
- 945-950
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2094477253
- Cited by
- 79
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm052084-05)
- National Institute of General Medical Sciences (GM 52084, GM-07223, T32GM007223, GM49370, R01GM049370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- serpins, serine protease inhibitors, Toll pathway, dorsoventral polarity, Drosophila embryo, spatial regulation of signaling, antithrombin III, protease inhibition
- MeSH terms
- Amino Acid Sequence, Animals, Drosophila, Molecular Sequence Data, Receptors, Cell Surface, Signal Transduction, Serpins, Gene Expression Regulation, Developmental, Body Patterning, Drosophila Proteins, Toll-Like Receptors
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