The DOI matches its Crossref record; 73 of the 83 references it cites were found in a registry or an index.
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
Open accessAbstract
ErbB2 is a ligand-less member of the ErbB receptor family that functions as a coreceptor with EGFR, ErbB3, and ErbB4. Here, we describe an approach to target ErbB2's role as a coreceptor using a monoclonal antibody, 2C4, which sterically hinders ErbB2's recruitment into ErbB ligand complexes. Inhibition of ligand-dependent ErbB2 signaling by 2C4 occurs in both low- and high-ErbB2-expressing systems. Since the ErbB3 receptor contains an inactive tyrosine kinase domain, 2C4 is very effective in blocking heregulin-mediated ErbB3-ErbB2 signaling. We demonstrate that the in vitro and in vivo growth of several breast and prostate tumor models is inhibited by 2C4 treatment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is likely that also heregulin-driven tumors lacking HER2 amplification may benefit from HER2-directed therapies [92, 95, 96]”
From Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies (2014) · cites this paper as [96]
In the citing paper
“This is consistent with data showing that trastuzumab is unable to block ligand-induced HER2-containing heterodimers (Agus et al., 2002).”
From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Agus et al., 2002
Citations
Cites
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974
Self-citationReal time quantitative PCR.Preprint
Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768
Cobleigh, M., Vogel, C. L., Tripathy, D., Robert, N. J., Scholl, S., Fehrenbacher, L., Wolter, J. M., Paton, V. E., Shak, S., Lieberman, G., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.9.2639 · Cited by 2,767
A novel method for real time quantitative RT-PCR.Preprint
Gibson, U. E., Heid, C., & Williams, P. M. (1996) · Genome Research · doi:10.1101/gr.6.10.995 · Cited by 2,090
Graus-Porta, D., Beerli, R. R., Daly, J. M., & Hynes, N. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1647 · Cited by 1,617
The EGF receptor family as targets for cancer therapy
Mendelsohn, J. M., & Baselga, J. M. (2000) · Oncogene · doi:10.1038/sj.onc.1204082 · Cited by 1,341
Hidalgo, M., Siu, L. L., Nemunaitis, J., Rizzo, J., Hammond, L. A., Takimoto, C., Eckhardt, S. G., Tolcher, A., Britten, C. D., Denis, L., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.13.3267 · Cited by 1,001
Research works printed but not linked: 6
- Agus, 1999, Prostate cancer cell cycle regulators, J. Natl. Cancer Inst., 91, 1869, 10.1093/jnci/91.21.1869 · DOI
- Lewis, 1996, Growth regulation of human breast and ovarian tumor cells by heregulin, Cancer Res., 56, 1457
- Nagabhushan, 1996, CWR22, Cancer Res., 56, 3042
- Pinkas-Kramarski, 1996, Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions, EMBO J., 15, 2452, 10.1002/j.1460-2075.1996.tb00603.x · DOI
- Tzahar, 1998, The ErbB-2/HER2 oncogenic receptor of adenocarcinomas, Biochim. Biophys. Acta, 1377, M25
- Wainstein, 1994, CWR22, Cancer Res., 54, 6049
Cited by
Sorted by citations
Items 401–500 of 874
Cell‐specific biomarkers and targeted biopharmaceuticals for breast cancer treatment
Liu, M., Li, Z., Yang, J., Jiang, Y., Chen, Z., Ali, Z., He, N., & Wang, Z. (2016) · Cell Proliferation · doi:10.1111/cpr.12266 · Cited by 37
Shin, J. W., Kim, S., Ha, S., Choi, B., Kim, S., Im, S., Yoon, T., & Chung, J. (2019) · Biomolecules · doi:10.3390/biom9100629 · Cited by 36
HER‐2: A biomarker at the crossroads of breast cancer immunotherapy and molecular medicine
Pupa, S. M., Tagliabue, E., Ménard, S., & Anichini, A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20387 · Cited by 36
Leung, K.-M., Batey, S., Rowlands, R. J., Isaac, S. J., Jones, P. C., Drewett, V., Carvalho, J., Gaspar, M. A., Weller, S., Medcalf, M., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.127 · Cited by 35
Rosemblit, C., Datta, J., Lowenfeld, L., Xu, S., Basu, A. B., Kodumudi, K. N., Wiener, D. A., & Czerniecki, B. J. (2018) · Oncotarget · doi:10.18632/oncotarget.25208 · Cited by 37
Cancer Immunotherapy: The Dawn of Antibody Cocktails
Marrocco, I., Romaniello, D., & Yarden, Y. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8958-4_2 · Cited by 36
Novel Mutations of Epidermal Growth Factor Receptor in Localized Prostate Cancer
Diah, A. D. (2006) · Frontiers in bioscience · doi:10.2741/1986 · Cited by 35
A Review of Antibody Therapeutics and Antibody-Related Technologies for Oncology
Scallon, B. J., Snyder, L. A., Anderson, G. M., Chen, Q., Li, Y., Weiner, L. M., & Nakada, M. T. (2006) · Journal of Immunotherapy · doi:10.1097/01.cji.0000199196.97845.c3 · Cited by 35
Diermeier‐Daucher, S., Breindl, S., Buchholz, S., Ortmann, O., & Brockhoff, G. (2011) · Cytometry Part A · doi:10.1002/cyto.a.21107 · Cited by 34
Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3912 · Cited by 34
Akbari, V., Mir Mohammad Sadeghi, H., Jafrian-Dehkordi, A., Abedi, D., & Chou, C. P. (2014) · Journal of Industrial Microbiology and Biotechnology · doi:10.1007/s10295-014-1437-0 · Cited by 34
Cardiac toxicity of trastuzumab in elderly patients with breast cancer
Denegri, A., Moccetti, T., Moccetti, M., Spallarossa, P., Brunelli, C., & Ameri, P. (2016) · PubMed Central · doi:10.5167/uzh-128548 · Cited by 34
Barnes, C. J., & Kumar, R. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023726827771 · Cited by 34
de Goeij, B. E. C. G., Peipp, M., de Haij, S., van den Brink, E. N., Kellner, C., Riedl, T., de Jong, R. N., Vink, T., Strumane, K., Bleeker, W. K., et al. (2014) · mAbs · doi:10.4161/mabs.27705 · Cited by 33
Pertuzumab in HER2-positive breast cancer
Şendur, M. A. N., Aksoy, S., & Altundağ, K. (2012) · Current Medical Research and Opinion · doi:10.1185/03007995.2012.728132 · Cited by 33
Advances in First-Line Treatment for Patients with HER-2+ Metastatic Breast Cancer
Mattos‐Arruda, L. D., & Cortés, J. (2012) · The Oncologist · doi:10.1634/theoncologist.2011-0187 · Cited by 34
Predicting the Efficacy of HER2-Targeted Therapies: A Look at the Host
Modica, M. D., Tagliabue, E., & Triulzi, T. (2017) · Disease Markers · doi:10.1155/2017/7849108 · Cited by 33
Pereira, P. M. R., Mandleywala, K., Ragupathi, A., Carter, L. M., Goos, J. A. C. M., Janjigian, Y. Y., & Lewis, J. S. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.119.225813 · Cited by 33
Risk of rash with the anti-HER2 dimerization antibody pertuzumab: a meta-analysis
Drucker, A. M., Wu, S., Dang, C. T., & Lacouture, M. E. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2157-7 · Cited by 33
Immunological inhibition of carcinogenesis
Spadaro, M., Lanzardo, S., Curcio, C., Forni, G., & Cavallo, F. (2004) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-003-0483-7 · Cited by 33
Wang, Y., Li, H., Liang, Q., Liu, B., Mei, X., & Ma, Y.-J. (2014) · Tumor Biology · doi:10.1007/s13277-014-2722-2 · Cited by 32
Kao, C., Cheng, Y., Yang, M., Cha, T., Sun, G., Ho, C., Lin, Y., Wang, H., Wu, S., & Way, T. (2021) · Environmental Toxicology · doi:10.1002/tox.23332 · Cited by 32
Robert, N. J., Goertz, H., Chopra, P., Jiao, X., Yoo, B., Patt, D. A., & Antao, V. (2017) · Drugs - Real World Outcomes · doi:10.1007/s40801-016-0102-5 · Cited by 32
Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARγ
Hedvat, M., Jain, A., Carson, D. A., Leoni, L. M., Huang, G., Holden, S., Lu, D., Corr, M., Fox, W., & Agus, D. B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.05.014 · Cited by 32
Self-citationModern Antibody Technology: The Impact on Drug Development
Moroney, S. E., & Plückthun, A. (2005) · Wiley eBooks · doi:10.1002/9783527620982.ch48 · Cited by 32
Hu, S., Dai, H., Li, T. X., Tang, Y., Fu, W., Yuan, Q., Wang, F., Lv, G., Lv, Y., Fan, X., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.022 · Cited by 31
Targeting HER2 Positive Breast Cancer with Chemopreventive Agents
Wahler, J., & Suh, N. (2015) · Current Pharmacology Reports · doi:10.1007/s40495-015-0040-z · Cited by 31
Robinson, A. G., Turbin, D. A., Thomson, T., Yorida, E., Ellard, S. L., Bajdik, C. D., Huntsman, D. D., & Gelmon, K. A. (2006) · Clinical Breast Cancer · doi:10.3816/cbc.2006.n.038 · Cited by 31
Antibody therapy for breast cancer.
Willems, A., Gauger, K., Henrichs, C., & Harbeck, N. (2005) · PubMed · Cited by 31
Κoletsa, T., Kostopoulos, I. S., Charalambous, E., Christoforidou, B. P., Nenopoulou, E., & Kotoula, V. (2008) · Neoplasia · doi:10.1593/neo.08314 · Cited by 30
Ma, Z., Li, Q., An, H., Pankonin, M. S., Wang, J., & Loeb, J. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032714 · Cited by 31
Molecular imaging of human epidermal growth factor receptor 2 (HER-2) expression
Niu, G. (2007) · Frontiers in bioscience · doi:10.2741/2720 · Cited by 30
Trastuzumab and Antiestrogen Therapy
Ocaña, A., Cruz, J. J., & Pandiella, A. (2006) · American Journal of Clinical Oncology · doi:10.1097/01.coc.0000190274.00570.0a · Cited by 30
Pertuzumab for the treatment of ovarian cancer
Langdon, S. P., Faratian, D., Nagumo, Y., Mullen, P., & Harrison, D. J. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2010.487062 · Cited by 29
Pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer
Kawajiri, H., Takashima, T., Kashiwagi, S., Noda, S., Onoda, N., & Hirakawa, K. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.992418 · Cited by 29
Antonarelli, G., Corti, C., Tarantino, P., Salimbeni, B. T., Zagami, P., Marra, A., Trapani, D., Tolaney, S. M., Cortés, J., & Curigliano, G. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101608 · Cited by 29
Targeting Receptor Tyrosine Kinases in Cancer
Köstler, W. J., & Zielinski, C. C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-2053-2_10 · Cited by 26
Monteiro, I., Madureira, P., de Vasconscelos, A., Pozza, D. H., & de Mello, R. A. (2015) · Pharmacogenomics · doi:10.2217/pgs.14.133 · Cited by 29
Use of Pertuzumab for the Treatment of HER2-Positive Metastatic Breast Cancer
Mattos‐Arruda, L. D., & Cortés, J. (2013) · Advances in Therapy · doi:10.1007/s12325-013-0043-2 · Cited by 29
Somatic pharmacogenomics in cancer
Ikediobi, O. N. (2008) · The Pharmacogenomics Journal · doi:10.1038/tpj.2008.8 · Cited by 29
ErbB-2 signaling in advanced prostate cancer progression and potential therapy
Miller, D. R., Ingersoll, M. A., & Lin, M. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0009 · Cited by 31
Kazemi, T., Tahmasebi, F., Bayat, A. A., Mohajer, N., Khoshnoodi, J., Jeddi‐Tehrani, M., Rabbani, H., & Shokri, F. (2011) · Hybridoma · doi:10.1089/hyb.2011.0023 · Cited by 28
Goltsov, A., Deeni, Y., Khalil, H. S., Soininen, T., Kyriakidis, S., Hu, H., Langdon, S. P., Harrison, D. J., & Bown, J. (2014) · Cells · doi:10.3390/cells3020563 · Cited by 28
Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α
Serdar, C. C., Cokol, M., Cingöz, S., Tasan, I., Öztürk, M., & Yağcı, T. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-450 · Cited by 28
Escalating and de-escalating treatment in HER2-positive early breast cancer
Joensuu, H. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.11.002 · Cited by 28
Promising tumor‐associated antigens for future prostate cancer therapy
Li, Y., Cozzi, P. J., & Russell, P. J. (2009) · Medicinal Research Reviews · doi:10.1002/med.20165 · Cited by 28
FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration
Zhou, L., Jiang, S., Fu, Q., SMITH, K., Tu, K., Li, H., & Zhao, Y. (2016) · Oncology Reports · doi:10.3892/or.2016.4627 · Cited by 28
Rockberg, J., Schwenk, J. M., & Uhlén, M. (2009) · Molecular Oncology · doi:10.1016/j.molonc.2009.01.003 · Cited by 28
Current and emerging therapies of HER2-positive metastatic breast cancer
Hernández-Blanquisett, A., Touya, D., Strasser‐Weippl, K., Ruiz, R., Louis, J. S., & Goss, P. E. (2016) · The Breast · doi:10.1016/j.breast.2016.07.026 · Cited by 28
Henegouwen, J. M. V. B., Jebbink, M., Hoes, L. R., van der Wijngaart, H., Zeverijn, L. J., Velden, D. L. V. D., Roepman, P., de Leng, W. W. J., Jansen, A. M. L., van Werkhoven, E. D., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.05.009 · Cited by 28
Emerging therapies in gastrointestinal cancers
Nautiyal, J. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i46.7440 · Cited by 27
Trastuzumab resistance: all roads lead to SRC
Muthuswamy, S. K. (2011) · Nature Medicine · doi:10.1038/nm0411-416 · Cited by 27
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3
Sak, M. M., Szymańska, M., Bertelsen, V., Hasmann, M., Madshus, I. H., & Stang, E. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt173 · Cited by 27
ErbB2 IS A TUMOR ASSOCIATED ANTIGEN AND A SUITABLE THERAPEUTIC TARGET IN WILMS TUMOR
Pinthus, J. H., Fridman, E., Dekel, B., Goldberg, I., Kaufman‐Francis, K., Eshhar, Z., Harmelin, A., Rechavi, G., Mor, O., Ramon, J., et al. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000140139.91993.a0 · Cited by 27
Ovarian Cancer: Opportunity for Targeted Therapy
Tagawa, T., Morgan, R. J., Yen, Y., & Mortimer, J. E. (2011) · Journal of Oncology · doi:10.1155/2012/682480 · Cited by 26
McCormack, P. L. (2013) · Drugs · doi:10.1007/s40265-013-0109-0 · Cited by 26
Huang, Y., Fu, P., & Fan, W. (2013) · Current Drug Targets · doi:10.2174/13894501113149990161 · Cited by 26
Hendry, J. M., Alvarez‐Veronesi, M. C., Placheta, E., Zhang, J. J., Gordon, T., & Borschel, G. H. (2016) · Annals of Neurology · doi:10.1002/ana.24688 · Cited by 26
Yamashita‐Kashima, Y., Shu, S., Yorozu, K., Moriya, Y., & Harada, N. (2017) · Oncology Letters · doi:10.3892/ol.2017.6679 · Cited by 26
Canonici, A., Qadir, Z., Conlon, N. T., Collins, D. M., O’Brien, N. A., Walsh, N., Eustace, A. J., O’Donovan, N., & Crown, J. P. (2018) · Investigational New Drugs · doi:10.1007/s10637-017-0556-7 · Cited by 26
Liu, S., Xie, S. M., Liu, W., Gagea, M., Hanker, A. B., Nguyen, N. T., Raghavendra, A. S., Yang-Kolodji, G., Chu, F., Neelapu, S. S., et al. (2023) · Breast Cancer Research · doi:10.1186/s13058-023-01665-w · Cited by 29
Maly, J. J., & Macrae, E. R. (2014) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s9032 · Cited by 26
Sensitization of HER2 Positive Breast Cancer Cells to Lapatinib Using Plants-Derived Isothiocyanates
Kaczyńska, A., Świerczyńska, J., & Herman-Antosiewicz, A. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1053498 · Cited by 26
Newer Therapies in Advanced Prostate Cancer
Hegeman, R. B., Liu, G., Wilding, G., & McNeel, D. G. (2004) · Clinical Prostate Cancer · doi:10.3816/cgc.2004.n.025 · Cited by 26
Pohl, M., Stricker, I., Schoeneck, A., Schulmann, K., Klein‐Scory, S., Schwarte‐Waldhoff, I., Hasmann, M., Tannapfel, A., Schmiegel, W., & Reinacher-Schick, A. C. (2009) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-009-0579-3 · Cited by 25
Waterhouse, B. R., Gijsen, M., Barber, P. R., Tullis, I. D. C., Vojnovic, B., & Kong, A. H. (2011) · Oncotarget · doi:10.18632/oncotarget.313 · Cited by 25
Molecular basis for prostate cancer racial disparities
Singh, R. (2016) · Frontiers in bioscience · doi:10.2741/4493 · Cited by 25
Araki, K., Fukada, I., Yanagi, H., Kobayashi, K., Shibayama, T., Horii, R., Takahashi, S., Akiyama, F., Ohno, S., & Ito, Y. (2017) · The Breast · doi:10.1016/j.breast.2017.06.015 · Cited by 25
O’Shaughnessy, J., Robert, N. J., Annavarapu, S., Zhou, J., Sussell, J. A., Cheng, A., & Fung, A. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06137-3 · Cited by 25
Gameiro, A., Nascimento, C., Correia, J., & Ferreira, F. (2021) · Cancers · doi:10.3390/cancers13092007 · Cited by 28
Krutilina, R. I., Hartman, K. L., Oluwalana, D., Playa, H. C., Parke, D. N., Chen, H., Miller, D. D., Li, W., & Seagroves, T. N. (2022) · Cancers · doi:10.3390/cancers14215336 · Cited by 26
HER2+ advanced gastric cancer: Current state and opportunities (Review)
Hu, H.-H., Wang, S., Zhao, H., Chen, Z., Shi, X., & Chen, X. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5624 · Cited by 30
Monoclonal antibodies therapies for ovarian cancer
Maggiore, U. L. R., Bellati, F., Ruscito, I., Gasparri, M. L., Alessandri, F., Venturini, P. L., & Ferrero, S. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.767328 · Cited by 25
A Molecular View of Anti-ErbB Monoclonal Antibody Therapy
Leahy, D. J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.010 · Cited by 25
Lyu, H., Yang, X. H., Edgerton, S. M., Thor, A. D., Wu, X., He, Z., & Liu, B. (2015) · Oncotarget · doi:10.18632/oncotarget.6404 · Cited by 25
Wang, Q., Zhang, X., Shen, E., Gao, J., Cao, F., Wang, X., Li, Y., Tian, T., Wang, J., Chen, Z., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.06.005 · Cited by 25
Expression of erbB receptors mRNA in thyroid tissues
Kato, S., Kobayashi, T., Yamada, K., Nishii, K., Sawada, H., Ishiguro, H., Itoh, M., Funahashi, H., & Nagasaka, A. (2004) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.04.016 · Cited by 25
Sewell, J. M., SMYTH, J., & Langdon, S. P. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.11.007 · Cited by 25
Expression of NRG1 and its receptors in human bladder cancer
Forster, J. A., Paul, A., Harnden, P., & Knowles, M. A. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.39 · Cited by 24
Tian, Y., Jia, X., Wang, S., Li, Y., Zhao, P., Cai, D., Zhou, Z., Wang, J., Luo, Y., & Dong, M. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1660-0 · Cited by 24
RetractedHER2 targeting near‐infrared photoimmunotherapy for a CDDP‐resistant small‐cell lung cancer
Takahashi, K., Taki, S., Yasui, H., Nishinaga, Y., Isobe, Y., Matsui, T., Shimizu, M., Koike, C., & Sato, K. (2021) · Cancer Medicine · doi:10.1002/cam4.4381 · Cited by 25
Liu, X., Luan, L., Liu, X., Jiang, D., Deng, J., Xu, J., Yuan, Y., Xing, J., Chen, B.-G., Xing, D., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1292839 · Cited by 27
Two Dimensions in Targeting HER2
Moasser, M. M. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.7652 · Cited by 24
Antibody-based identification of cell surface antigens: targets for cancer therapy
Loo, D. T., & Mather, J. P. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.08.011 · Cited by 24
Monoclonal antibody therapies for solid tumors
Tassev, D. V., & Cheung, N. V. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590802715764 · Cited by 24
Yang, Y., Ren, F., Tian, Z., Song, W., Cheng, B., & Feng, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01392 · Cited by 24
Montero, J. C., Barrueco, R. R., Yuste, L., Juanes, P. P., Borges, J., Esparı́s-Ogando, A., & Pandiella, A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0511 · Cited by 24
Domenech, J. M. D., Fernández, P. L., Filella, X., Martinez-Fernandez, A., Molina, R., Fernández, E., Alcaraz, A., Codony, J., Gascón, P., & Mellado, B. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm490 · Cited by 24
Fromont, G., Chêne, L., Vidaud, M., Vallancien, G., Mangin, P., Fournier, G., Validire, P., Latil, A., & Cussenot, O. (2004) · International Journal of Cancer · doi:10.1002/ijc.20704 · Cited by 24
Campone, M., Juin, P. P., André, F., & Bachelot, T. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.04.012 · Cited by 23
Lordick, F. (2011) · Future Oncology · doi:10.2217/fon.10.178 · Cited by 23
Pollmann, S. E., Brix, S., Grandal, M. M., Lantto, J., Horak, I. D., Kragh, M., & Poulsen, T. T. (2016) · International Journal of Cancer · doi:10.1002/ijc.30242 · Cited by 23
Pertuzumab: A New Targeted Therapy for HER 2‐Positive Metastatic Breast Cancer
Malenfant, S. J., Eckmann, K. R., & Barnett, C. M. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1338 · Cited by 23
Combining epitope-distinct antibodies to HER2: cooperative inhibitory effects on invasive growth
Emde, A., Pradeep, C.-R., Ferraro, D. A., Ben‐Chetrit, N., Sela, M., Ribba, B., Kam, Z., & Yarden, Y. (2010) · Oncogene · doi:10.1038/onc.2010.547 · Cited by 23
Phosphoinositides signalling in cancer: Focus on PI3K and PLC
Raimondi, C., & Falasca, M. (2011) · Advances in Biological Regulation · doi:10.1016/j.advenzreg.2011.09.016 · Cited by 24
Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer
Umelo, I. A., Noeparast, M., Chen, G., Renard, M., Geers, C., Vansteenkiste, J., Giron, P., Wever, O. D., Teugels, E., & Grève, J. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6585 · Cited by 23
Pertuzumab for the treatment of breast cancer: a safety review
Gao, J. J., & Swain, S. M. (2016) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2016.1167185 · Cited by 23
Targeting EGFR/HER2 heterodimerization with a novel anti-HER2 domain II/III antibody
Yu, X., Wang, L., Shen, Y., Wang, C., Zhang, Y., Meng, Y., Yang, Y., Liang, B., Zhou, B., Wang, H., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.05.010 · Cited by 23
Can Trastuzumab Be Effective Against Tumors With Low HER2/Neu (ErbB2) Receptors?
Arteaga, C. L. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.5268 · Cited by 23
Targeted therapy for advanced esophagogastric adenocarcinoma
Kordes, S., Cats, A., Meijer, S. L., & van Laarhoven, H. W. M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.10.004 · Cited by 22
Metadata
- Authors
- Agus, D. B., Akita, R. W., Fox, W. D., Lewis, G. D., Higgins, B., Pisacane, P. I., Lofgren, J. A., Tindell, C., Evans, D. P., Maiese, K., Scher, H. I., & Sliwkowski, M. X.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Genentech (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Sliwkowski, Mark X
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 2
- Issue
- 2
- Pages
- 127-137
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2014457594
- Cited by
- 873
- References
- 83
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 21 · 2023: 38 · 2022: 21 · 2021: 21 · 2020: 28 · 2019: 29 · 2018: 27 · 2017: 24 · 2016: 38 · 2015: 48 · 2014: 69 · 2013: 59 · 2012: 51
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- PepsiCo
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- ERBB2, HER2, HER3, neuregulin-1, ErbB receptor family, breast cancer, prostate cancer, tumor growth inhibition, tyrosine kinase inhibitors
- MeSH terms
- Androgens, Animals, Antibodies, Monoclonal, Antineoplastic Agents, Breast Neoplasms, Cell Division, Female, Humans, Ligands, Male, Neoplasm Transplantation, Prostatic Neoplasms, Protein Binding, RNA, Messenger, Time Factors, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Gene Expression Regulation, Neoplastic, Erb-b2 Receptor Tyrosine Kinases, Neuregulin-1, Receptor, ErbB-3, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review