Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis.
Abstract
Ectodysplasin (Eda), a member of the tumor necrosis factor (TNF) superfamily, and its receptor Edar are necessary components of ectodermal organ development. Analysis of their expression patterns and mutant phenotypes has shown that during mouse hair and tooth development they may be involved in signalling between separate epithelial compartments. Here we have analysed ectodysplasin and Edar expression in other embryonic mouse tissues, and show that Edar mRNA is confined to the epithelium. Ectodysplasin and Edar are expressed in separate epithelial compartments in the developing brain and the lacrimal gland. In the salivary gland ectodysplasin is expressed in the mesenchyme and Edar in the epithelium. This is the first indication of ectodysplasin-Edar signalling between the epithelium and the mesenchyme. We also studied the expression pattern of a related TNF receptor, TNFRSF19, and show that it is expressed in an overlapping domain with Edar in the tooth, mammary gland, whiskers, and limb bud suggesting a potentially redundant role.
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Both the expression of Edar and related receptor, Troy, have been detected in the AER of mice.
“both the expression of Edar and related receptor, Troy, have been detected in the AER of mice [40],[41].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [40]
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Harris, M. P., Rohner, N., Schwarz, H., Perathoner, S., Konstantinidis, P., & Nüsslein-Volhard, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000206 · Cited by 224 · see citing works
Species Composition and Environmental Adaptation of Indigenous Chinese Cattle
Gao, Y., Gautier, M., Ding, X., Zhang, H., Wang, Y., Wang, X., Faruque, M. O., Li, J., Ye, S., Gou, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16438-7 · Cited by 112 · see citing works
- Authors
- Pispa, J., Mikkola, M. L., Mustonen, T., & Thesleff, I.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Pispa, Johanna
- Thesleff, Irma
- Venue
- Gene Expression Patterns
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 3
- Issue
- 5
- Pages
- 675-679
- ISSN
- 1567-133X (ISSN-L)
- OpenAlex
- W2018395541
- Cited by
- 78
- References
- 0
- Citations by year
- 2026: 1 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Expression Patterns (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- ectodysplasin, EDAR, TNFRSF19, TNF superfamily, embryonic gene expression, brain development, lacrimal gland, salivary glands, tooth development, mammary gland, whiskers, limb bud, mouse embryo
- MeSH terms
- Amino Acid Sequence, Animals, Epithelium, Membrane Proteins, Molecular Sequence Data, Organ Specificity, Gene Expression, Receptors, Tumor Necrosis Factor, Gene Expression Regulation, Developmental, Gene Expression Profiling, Mice, Ectodysplasins, Receptors, Ectodysplasin, Edar Receptor
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