Gender-based differences in cardiac disease
Open accessAbstract
It has been observed that the incidence of heart failure and Brugada syndrome are higher in men, while women are more likely to have QT interval prolongation and develop torsades de pointes (TdP). Over the past decade, new studies have improved our understanding of the mechanisms of abnormal repolarization and the relationship between gender differences in cardiac repolarization and presentation of clinical syndromes. Nevertheless, the causes of gender-based differences in cardiac disease are still not completely clear. This review paper briefly summarized what is currently known about gender differences in heart failure, Brugada syndrome and long QT syndrome from molecular mechanisms to clinical presentations.
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Women are known to have on average smaller hearts and have differences in electrophysiology, and this relationship between heart size and tissue properties may not be explicitly represented in a model.
“For example, women are known to have on average smaller hearts and have differences in electrophysiology [69, 70], and this relationship between heart size and tissue properties may not be explicitly represented in a model.”
From Credibility assessment of in silico clinical trials for medical devices (2024) · cites this paper as [70]
The Introduction (page unavailable) describes intrinsic electrical differences between women and men, including differences in ion-channel expression. Our copy does not establish that women have smaller hearts on average. The statement about what a model may omit follows the citation and reads as the citing authors’ own observation. (LLM, conf=0.85)
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References 95 · Cited by 16
- Authors
- Yang, P.-C., & Clancy, C. E.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Yang, Pei-Chi
- Venue
- Journal of Biomedical Research
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 25
- Issue
- 2
- Pages
- 81-89
- ISSN
- 1674-8301 (ISSN-L)
- PMC
- PMC3596698
- OpenAlex
- W1980863653
- Cited by
- 16
- References
- 95
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2014: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biomedical Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- sex differences, heart failure, Brugada syndrome, long QT syndrome, QT prolongation, torsades de pointes, cardiac repolarization, molecular mechanisms
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