CoChat
Sign Up
Cited by 22

The DOI matches its Crossref record.

Characterization of acute adverse-effect profiles of selected antiepileptic drugs in the grip-strength test in mice

Zadrożniak, Anna, Wojda, Ewa, Wlaź, Aleksandra, J. Łuszczki, Jarogniew·2009·Pharmacological Reports
DOI 10.1016/s1734-1140(09)70128-8
Open this paper in CoChat — free account

Abstract

The aim of this study was to assess the acute adverse effects (neurotoxic) of several antiepileptic drugs (clonazepam, lamotrigine, oxcarbazepine, phenytoin, phenobarbital and topiramate) by measuring skeletal muscular strength in mice using the grip-strength test. Linear regression analysis of grip-strength in relation to drug dose-response allowed us to determine D(50) values, the dosages of antiepileptic drugs that reduced grip-strength in mice by 50% compared to control animals. Each of the antiepileptic drugs studied reduced skeletal muscular strength in mice in a dose-dependent manner. The D(50) for clonazepam was 31.7 mg/kg, lamotrigine -47.7 mg/kg, oxcarbazepine -87.3 mg/kg, phenobarbital -128.7 mg/kg, phenytoin -69.7 mg/kg, and topiramate -509.5 mg/kg. In conclusion, the grip-strength test can aid in evaluating acute adverse effects of drugs with respect to their influence on muscular strength in experimental animals.

Overview

Integrity signals

Registry

Crossref · 10.1016/s1734-1140(09)70128-8

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 15

  1. Deckers, 2000, Selection of antiepileptic drug polytherapy based on mechanisms of action:the evidence reviewed, Epilepsia, 41, 1364, 10.1111/j.1528-1157.2000.tb00111.x · DOI
  2. Kwan, 2006, Combination therapy in epilepsy:when and what to use, Drugs, 66, 1817, 10.2165/00003495-200666140-00004 · DOI
  3. Kwan, 2002, Refractory epilepsy: a progressive,intractable but preventable condition?, Seizure, 11, 77, 10.1053/seiz.2002.0593 · DOI
  4. Löscher, 1991, The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices, Epilepsy Res, 9, 1, 10.1016/0920-1211(91)90041-D · DOI
  5. Łuszczki, 2005, Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice, Eur Neuropsychopharmacol, 15, 609, 10.1016/j.euroneuro.2005.03.005 · DOI
  6. Łuszczki, 2003, Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis, Epilepsia, 44, 489, 10.1046/j.1528-1157.2003.32702.x · DOI
  7. Łuszczki, 2003, Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis, Epilepsia, 44, 1003, 10.1046/j.1528-1157.2003.10003.x · DOI
  8. Łuszczki, 2007, Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy, Prog Neuropsychopharmacol Biol Psychiatry, 31, 529, 10.1016/j.pnpbp.2006.11.020 · DOI
  9. Łuszczki, 2007, Effect of NG-nitro-L-arginine on the anticonvulsant action of four second-generation antiepileptic drugs in pentetrazoleinduced clonic seizures in mice, Pharmacol Rep, 59, 467
  10. Łuszczki, 2007, Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model, Pharmacol Rep, 59, 672
  11. Łuszczki, 2008, Characterization of acute adverse-effect profile of carbamazepine and valproate in the gripstrength test in mice, J Pre-Clin Clin Res, 2, 46
  12. Perucca, 2005, Overtreatment in epilepsy: how it occurs and how it can be avoided, CNS Drugs, 19, 897, 10.2165/00023210-200519110-00001 · DOI
  13. Perucca, 1995, Pharmacological principles as a basis for polytherapy, Acta Neurol Scand Suppl, 162, 31
  14. Schmidt, 2002, Strategies to prevent overtreatment with antiepileptic drugs in patients with epilepsy, Epilepsy Res, 52, 61, 10.1016/S0920-1211(02)00186-9 · DOI
  15. Talarek, 2008, Role of nitric oxide in the development of tolerance to diazepam-induced motor impairment in mice, Pharmacol Rep, 60, 475

Cited by

Sorted by citations

Metadata

Authors
Zadrożniak, A., Wojda, E., Wlaź, A., & J. Łuszczki, J.
Venue
Pharmacological Reports
Publisher
Springer Science and Business Media LLC
Published
2009-07
Volume
61
Issue
4
Pages
737-742
ISSN
1734-1140
DOI
10.1016/s1734-1140(09)70128-8
Cited by
22
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review