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Cited by 226Parasitic infections in humans and animalsHelminth infection and controlParasitic Infections and Diagnostics

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Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects

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Mandal, Shyamapada, Deb Mandal, Manisha·2012·Asian Pacific Journal of Tropical Medicine
DOI 10.1016/s1995-7645(12)60035-2
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Abstract

This review represents an updated scenario on the transmission cycle, epidemiology, clinical features and pathogenicity, diagnosis and treatment, and prevention and control measures of a cestode parasite Echincoccus granulosus (E. granulosus) infection causing cystic echinococcosis (CE) in humans. Human CE is a serious life-threatening neglected zoonotic disease that occurs in both developing and developed countries, and is recognized as a major public health problem. The life cycle of E. granulosus involves a definitive host (dogs and other canids) for the adult E. granulosus that resides in the intestine, and an intermediate host (sheep and other herbivores) for the tissue-invading metacestode (larval) stage. Humans are only incidentally infected; since the completion of the life cycle of E. granulosus depends on carnivores feeding on herbivores bearing hydatid cysts with viable protoscoleces, humans represent usually the dead end for the parasite. On ingestion of E. granulosus eggs, hydatid cysts are formed mostly in liver and lungs, and occasionally in other organs of human body, which are considered as uncommon sites of localization of hydatid cysts. The diagnosis of extrahepatic echinococcal disease is more accurate today because of the availability of new imaging techniques, and the current treatments include surgery and percutaneous drainage, and chemotherapy (albendazole and mebendazole). But, the wild animals that involve in sylvatic cycle may overlap and interact with the domestic sheep-dog cycle, and thus complicating the control efforts. The updated facts and phenomena regarding human and animal CE presented herein are due to the web search of SCI and non-SCI journals.

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Metadata

Authors
Mandal, S., & Deb Mandal, M.
Affiliations
Gurudas College (IN)
Corresponding author
Mandal, Shyamapada
ORCID
Mandal, Shyamapada
Venue
Asian Pacific Journal of Tropical Medicine
Publisher
Medknow
Published
2012-04
Volume
5
Issue
4
Pages
253-260
ISSN
1995-7645 (ISSN-L)
DOI
10.1016/s1995-7645(12)60035-2
OpenAlex
W2051024776
Cited by
226
References
0
Citations by year
2026: 10 · 2025: 16 · 2024: 17 · 2023: 22 · 2022: 18 · 2021: 13 · 2020: 27 · 2019: 17 · 2018: 13 · 2017: 18 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 14 · 2012: 5
FWCI
9.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Asian Pacific Journal of Tropical Medicine (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
Keywords
echinococcosis, Echinococcus granulosus, zoonotic parasitic disease, parasite life cycle, clinical features, diagnosis, surgical treatment, percutaneous drainage, albendazole, mebendazole, neglected tropical diseases, sylvatic transmission, disease prevention and control
MeSH terms
Animals, Anticestodal Agents, Dog Diseases, Dogs, Echinococcosis, Humans, Life Cycle Stages, Sheep, Sheep Diseases, Zoonoses, Prevalence, Echinococcus granulosus

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Mandal, S., & Deb Mandal, M. (2012). Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pacific Journal of Tropical Medicine. https://doi.org/10.1016/s1995-7645(12)60035-2