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Cited by 17

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

In vivo antiplasmodial activities of ethanolic exract and fractions of Eleucine indica

Ettebong, EO, Nwafor, PA, Okokon, JE·2012·Asian Pacific Journal of Tropical Medicine
DOI 10.1016/s1995-7645(12)60105-9
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Abstract

OBJECTIVE To evaluate the in vivo antiplasmodial activities of the extract and fractions (n-hexane, chloroform, ethylacetate, butanol, aqueous) of the whole plant in Plasmodium berghei berghei infected mice. METHODS Oral administrations of the extract (200, 400, and 600 mg/kg) of Eleucine indica and fractions (400 mg/kg) were screened in the 4-day, repository and curative tests. Chloroquine (5 mg/kg), pyrimethamine (1.2 mg/kg) and artesunate (5 mg/kg) were used as controls. RESULTS The extract showed significant (P< 0.05-0.001) dose-dependent, antiplasmodial activity in the 4-day, repository and curative tests and increased the survival times of the infected mice. All the fractions exhibited significant antiplasmodial activity with the highest being ethylacetate fraction. CONCLUSIONS Eleucine indica extract and fractions possess antimalarial activity which confirms the ethnobotanical use of this plant as a malarial remedy and opens a new highway to further investigate its potentials in the on-going fight against malaria.

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Research works printed but not linked: 20

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Metadata

Authors
Ettebong, E., Nwafor, P., & Okokon, J.
Venue
Asian Pacific Journal of Tropical Medicine
Publisher
Medknow
Published
2012-09
Volume
5
Issue
9
Pages
673-676
ISSN
1995-7645
DOI
10.1016/s1995-7645(12)60105-9
Cited by
17
References
1
Language
en
Licence

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CoChat. (2026). Citation check: In vivo antiplasmodial activities of ethanolic exract and fractions of Eleucine indica. https://app.cochat.ai/papers/10.1016/s1995-7645(12)60105-9
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Ettebong, E., Nwafor, P., & Okokon, J. (2012). In vivo antiplasmodial activities of ethanolic exract and fractions of Eleucine indica. Asian Pacific Journal of Tropical Medicine. https://doi.org/10.1016/s1995-7645(12)60105-9

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