The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial
Abstract
Background Suboptimum adherence to preventive asthma treatment is associated with substantial morbidity and mortality, yet adherence often remains poor. We aimed to investigate whether use of an inhaler with audiovisual reminders leads to improved adherence and asthma outcomes in school-aged children who presented to the emergency department with an asthma exacerbation.Methods We did a randomised controlled trial in patients aged 6-15 years who attended the regional emergency department in Auckland, New Zealand with an asthma exacerbation and were on regular inhaled corticosteroids. Using a simple, unrestricted block randomisation with block sizes of 200, we randomly assigned patients to receive an electronic monitoring device for use with their preventer inhaler with the audiovisual reminder functions either enabled to support adherence to inhaled corticosteroids (intervention group) or disabled (control group). Participants were followed up every 2 months for 6 months. The primary outcomes were adherence to preventive inhaled corticosteroids and number of days absent from school for any reason. Asthma control was assessed as a secondary outcome. All analyses were done in the intention-to-treat population. This trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12613001353785.Findings The study took place between May 10, 2010, and Feb 26, 2012. We randomly assigned 220 patients, 110 to the intervention group and 110 to the control group. Median percentage adherence was 84% (10th percentile 54%, 90th percentile 96%) in the intervention group, compared with 30% (8%, 68%) in the control group (p<0·0001). The proportion of days absent from school for any reason was 1·9% (10th percentile 0·0%, 90th percentile 7·9%) in the intervention group and 1·7% (0·0%, 8·6%) in the control group. The change in asthma morbidity score from baseline to 6 months was significantly greater in the intervention group than in the control group (p=0·008), with a reduction of 2·0 points from a mean baseline score of 9·3 (SD 2·2) to 7·3 (2·1) in the intervention group, compared with a reduction of 1·2 points from a baseline of 9·2 (2·5) to 8·0 (2·2) in the control group.Interpretation Use of an electronic monitoring device with an audiovisual reminder led to significant improvements in adherence to inhaled corticosteroids in school-aged children with asthma. This intervention could be beneficial for the improvement of asthma control in patients for whom poor asthma control is related to poor adherence.Funding Health Research Council of New Zealand and Cure Kids.
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“However, despite interventions and treatments aimed at addressing modifiable factors and comorbidities, some children with DA and Asthma plus may not improve [e.g., because of the continued poor adherence with medications (50, 68), or ongoing high exposure to allergens (69–71)], in which case they should be considered as having refractory DA or refractory Asthma plus (46, 72).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [68]
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Beasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,794
Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945
Development of the asthma control test
Nathan, R. A., Sorkness, C. A., Kosinski, M., Schatz, M., Li, J. T., Marcus, P., Murray, J. J., & Pendergraft, T. B. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.008 · Cited by 2,906
Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma
PAUWELS, R. A., Löfdahl, C., Postma, D. S., Tattersfield, A. E., O’Byrne, P. M., Barnes, P. J., & Ullman, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372001 · Cited by 1,518
Interventions to Enhance Patient Adherence to Medication Prescriptions: Scientific Review
McDonald, H. P., Garg, A. X., & Haynes, R. B. (2002) · JAMA · doi:10.1001/jama.288.22.2868 · Cited by 1,176
Low-Dose Inhaled Corticosteroids and the Prevention of Death from Asthma
Suissa, S., Ernst, P., Benayoun, S., Baltzan, M., & Cai, B. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430504 · Cited by 1,095
Lai, C.-Y., Beasley, R. W., Crane, J., Foliaki, S., Shah, J., Weiland, S. K., & the ISAAC Phase Three Study Group (2009) · Thorax · doi:10.1136/thx.2008.106609 · Cited by 1,063
Development and cross-sectional validation of the Childhood Asthma Control Test
Liu, A. H., Zeiger, R. S., Sorkness, C. A., Mahr, T. A., Ostrom, N. K., Burgess, S. M., Rosenzweig, J. C., & Manjunath, R. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.662 · Cited by 985
Pop-Eleches, C., Thirumurthy, H., Habyarimana, J. P., Zivin, J. G., Goldstein, M. P., de Walque, D., MacKeen, L., Haberer, J., Kimaiyo, S., Sidle, J., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834380c1 · Cited by 982
Research works printed but not linked: 2
- Black, 2008, An inhaler with ringtones improves compliance with inhaled steroids in childhood asthma, Am J Respir Crit Care Med, 177, A615
- Foster, 2011, Reliability and validity of the Smartrack device: a new electronic monitor for metered dose inhalers, Respirology, 16, 37
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Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
“, because of the continued poor adherence with medications (50, 68), or ongoing high exposure to allergens (69–71)], in which case they should be considered as having refractory DA or refractory Asthma plus (46, 72).”
BackgroundSulaiman, I., Greene, G., MacHale, E., Seheult, J. N., Mokoka, M., D’Arcy, S., Taylor, T. E., Murphy, D. M., Hunt, E. B., Lane, S. J., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01126-2017 · Cited by 196
Diagnosis and management of asthma in children
Martin, J., Townshend, J., & Brodlie, M. (2022) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2021-001277 · Cited by 212
Interventions to improve adherence to inhaled steroids for asthma
Normansell, R., Kew, K. M., & Stovold, E. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012226.pub2 · Cited by 183
Wearable Technology and How This Can Be Implemented into Clinical Practice
Greiwe, J., & Nyenhuis, S. M. (2020) · Current Allergy and Asthma Reports · doi:10.1007/s11882-020-00927-3 · Cited by 167
Metadata
- Authors
- Chan, A. H. Y., Stewart, A. W., Harrison, J., Camargo, C. A., Black, P. N., & Mitchell, E. A.
- Affiliations
- University of Auckland (NZ)
- Harvard University (US)
- Corresponding author
- Chan, Amy H Y
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 3
- Issue
- 3
- Pages
- 210-219
- ISSN
- 2213-2600 (ISSN-L)
- OpenAlex
- W2164117859
- Cited by
- 265
- References
- 60
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 25 · 2023: 21 · 2022: 21 · 2021: 22 · 2020: 25 · 2019: 37 · 2018: 27 · 2017: 22 · 2016: 18 · 2015: 6
- FWCI
- 28.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- medication adherence, inhaled corticosteroids, asthma, electronic monitoring devices, school attendance, asthma exacerbations, emergency department, children, asthma control, inhaler devices
- MeSH terms
- Absenteeism, Administration, Inhalation, Adolescent, Adrenal Cortex Hormones, Asthma, Child, Equipment Design, Humans, New Zealand, Schools, Treatment Outcome, Reminder Systems, Monitoring, Ambulatory, Anti-Asthmatic Agents, Medication Adherence
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