There is no magic bullet for obesity
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Around 10-30% of participants (especially people with T2D) achieved <10% weight loss in clinical trials even with the higher doses of the new pharmacotherapies.
“Around 10–30% of participants (especially people with T2D) achieved <10% WL in clinical trials even with the higher doses of the new pharmacotherapies [101, 102].”
From What is the pipeline for future medications for obesity? (2025) · cites this paper as [102]
The Abstract says that up to 20% of participants in obesity-treatment trials do not experience clinically significant weight loss, supporting the general point that some participants respond poorly. It does not define that outcome as less than 10% weight loss, give a 10–30% range, or say this occurs especially in people with type 2 diabetes or at higher medication doses. (LLM, conf=0.87)
Experimental — accuracy not yet measuredObesity is a complex, chronic and progressive disease.
“As obesity is a complex, chronic and progressive disease, it requires also an individualised and adaptive over time approach [14, 102].”
From What is the pipeline for future medications for obesity? (2025) · cites this paper as [102]
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References 5 · Cited by 16
- Authors
- Lingvay, I., Sumithran, P., le Roux, C. W., & Cohen, R. V.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Monash University (AU)
- Hospital Alemão Oswaldo Cruz (BR)
- Corresponding author
- Cohen, Ricardo V
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 11
- Issue
- 8
- Pages
- 541
- ISSN
- 2213-8587 (ISSN-L)
- OpenAlex
- W4385248365
- Cited by
- 16
- References
- 5
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 3
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- Sanofi
- Mylan
- Science Foundation Ireland
- Irish Research Council
- Novo Nordisk
- Medical Research Council
- National Health and Medical Research Council
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
- Keywords
- obesity, obesity pharmacotherapy, weight loss, weight regain, semaglutide, GLP-1 receptor agonists, lifestyle intervention, metabolic surgery, personalized treatment, chronic disease management, media coverage
- MeSH terms
- Bisacodyl, Humans, Obesity
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