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Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Open accessAbstract
BACKGROUND: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures. METHODS: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed. FINDINGS: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2-128·4), with a global prevalence of 1·52% (95% UI 1·33-1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41-17·87] in those aged 80-84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2-74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles. INTERPRETATION: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors. FUNDING: Bill & Melinda Gates Foundation.
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2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease
Gerhard-Herman, M. D., Gornik, H. L., Barrett, C., Barshes, N. R., Corriere, M. A., Drachman, D. E., Fleisher, L. A., Fowkes, F. G. R., Hamburg, N. M., Kinlay, S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.007 · Cited by 1,941
Cited by
Martin, S. S., Aday, A. W., Allen, N. B., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Bansal, N., Beaton, A. Z., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001303 · Cited by 1,080
Self-citation2024 ESC Guidelines for the management of peripheral arterial and aortic diseases
Mazzolai, L., Teixido-Tura, G., Lanzi, S., Boc, V., Bossone, E., Brodmann, M., Bura-Rivière, A., De Backer, J., Deglise, S., Della Corte, A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae179 · Cited by 993
Metadata
- Authors
- Kim, M. S., Hwang, J., Yon, D. K., Lee, S. W., Jung, S. Y., Park, S., Johnson, C. O., Stark, B. A., Razo, C., Abbasian, M., Abbastabar, H., Abhari, A. P., Aboyans, V., Adane, D. E. A., Adebayo, O. M., Alahdab, F., Almustanyir, S., Aly, H., Ameyaw, E. K., Anderson, J. A., Andrei, C. L., Aryan, Z., Aujayeb, A., Bagherieh, S., Baltatu, O. C., Banach, M., Bayileyegn, N. S., Bearne, L. M., Behnoush, A. H., Bensenor, I. M., Bhaskar, S., Bhat, A. N., Bhat, V., Bikbov, B., Bintoro, B. S., Burkart, K., Cámera, L. A., Catapano, A. L., Chandrasekar, E. K., Charan, J., Chattu, V. K., Chi, G., Chukwu, I. S., Chung, S.-C., Cirillo, M., Coberly, K., Costa, V. M., Dadras, O., Dai, X., Do, T. C., Doshi, R., Ekholuenetale, M., Elgendy, I. Y., Elhadi, M., Fagbamigbe, A. F., Feizkhah, A., Fekadu, G., Gill, P. S., Goldust, M., Golechha, M., Guan, S.-Y., Gupta, V. K., Hadei, M., Hadi, N. R., Hammoud, A., Hankey, G. J., Harlianto, N. I., Hasaballah, A. I., Hassan, S., Hassen, M. B., Heidari, G., Hostiuc, M., Ilesanmi, O. S., Iwagami, M., Jokar, M., Jonas, J. B., Joshua, C. E., Jozwiak, J. J., Kazemian, S., Keykhaei, M., Khalaji, A., Khan, M. A., Khateri, S., Kibret, B. G., Korzh, O., Koulmane Laxminarayana, S. L., Krishan, K., Kumar, A., Kumar, M., Kuttikkattu, A., Laksono, T., Larijani, B., Le, T. T. T., Lim, S. S., Liu, X., Lorkowski, S., Magdy Abd El Razek, H., Malhotra, K., Manla, Y., Maugeri, A., Mentis, A.-F. A., Mestrovic, T., Micheletti Gomide Nogueira de Sá, A. C., Mirica, A., Mirrakhimov, E. M., Misganaw, A., Mishra, M., Mohammad, Y., Mokdad, A. H., Moni, M. A., Montasir, A. A., Moradi, Y., Moraga, P., Morovatdar, N., Mousavi-Aghdas, S. A., Murray, C. J. L., Naghavi, M., Nair, T. S., Nassereldine, H., Natto, Z. S., Nguyen, D. H., Nguyen, H. Q., Nguyen, V. T., Noubiap, J. J., Oancea, B., Oliveira, G. M. M., Owolabi, M. O., Padron-Monedero, A., Perico, N., Petcu, I.-R., Radfar, A., Rafferty, Q., Rahman, M., Rahman, M. A., Ram, P., Rashedi, S., Rashid, A. M., Rawaf, S., Remuzzi, G., Renzaho, A. M. N., Rezaee, M., Roever, L., Saad, A. M. A., Saadatagah, S., Sadeghi, M., Sahebkar, A., Saleh, M. A., Samy, A. M., Santric-Milicevic, M. M., Sepanlou, S. G., Seylani, A., Sharfaei, S., Shorofi, S. A., Singh, J. A., Singh, P., Spartalis, M., Sundström, J., Tan, K.-K., Teramoto, M., Tharwat, S., Tyrovolas, S., Valadan Tahbaz, S., Van den Eynde, J., Vart, P., Wang, C., Wang, F., Westerman, R., Xia, J., Xu, S., Yada, D. Y., Yamagishi, K., Yonemoto, N., Zahir, M., Zangiabadian, M., Zarrintan, A., Zastrozhin, M. S., Zastrozhina, A., Zoladl, M., Hay, S. I., Shin, J. I., & Roth, G. A.
- Venue
- The Lancet Global Health
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 11
- Issue
- 10
- Pages
- e1553-e1565
- ISSN
- 2214-109X (ISSN-L)
- OpenAlex
- W4386854707
- Cited by
- 268
- References
- 36
- FWCI
- 63.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kim, M. S., Hwang, J., Yon, D. K., Lee, S. W., Jung, S. Y., Park, S., Johnson, C. O., Stark, B. A., Razo, C., Abbasian, M., Abbastabar, H., Abhari, A. P., Aboyans, V., Adane, D. E. A., Adebayo, O. M., Alahdab, F., Almustanyir, S., Aly, H., Ameyaw, E. K., . . . Roth, G. A. (2023). Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Global Health. https://doi.org/10.1016/s2214-109x(23)00355-8
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