Addiction and physical dependence are not the same thing
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In basic pharmacology and addiction medicine, neurophysiological adaptations are typically defined as physical dependence, and a withdrawal syndrome upon dose reduction or treatment discontinuation is its sole clinical manifestation.
“In basic pharmacology and addiction medicine, these neurophysiological adaptations are typically defined as physical dependence (no to be confused with addiction) and a withdrawal syndrome upon dose reduction or treatment discontinuation is its sole clinical manifestation (Horowitz et al., 2023; Horowitz and Taylor, 2023; Lerner and Klein, 2019).”
From Post-acute withdrawal syndrome (PAWS) after stopping antidepressants: a systematic review with meta-narrative synthesis (2025) · cites this paper as Horowitz and Taylor, 2023
Severe withdrawal from physical dependence alone does not imply addiction.
“Severe withdrawal from physical dependence alone does not imply addiction.”
From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Horowitz & Taylor, 2023
The citation lists haven’t been fetched yet
References 4 · Cited by 16
- Authors
- Horowitz, M. A., & Taylor, D.
- Affiliations
- North East London NHS Foundation Trust (GB)
- King's College London (GB)
- Corresponding author
- Horowitz, Mark Abie
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 10
- Issue
- 8
- Pages
- e23
- ISSN
- 2215-0366 (ISSN-L)
- OpenAlex
- W4385064166
- Cited by
- 16
- References
- 4
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- addiction, physical dependence, terminology, drug prescribing, NHS England
- MeSH terms
- Humans, Behavior, Addictive, Substance-Related Disorders
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