The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Leukaemia and myeloid malignancy among people exposed to low doses (<100 mSv) of ionising radiation during childhood: a pooled analysis of nine historical cohort studies
Open accessAbstract
Background Substantial evidence links exposure to moderate or high doses of ionising radiation, particularly in childhood, with increased risk of leukaemia. The association of leukaemia with exposure to low-dose (<100 mSv) radiation is less certain, although this is the dose range most relevant to the general population. We aimed to estimate the risk of leukaemia associated with low-dose radiation exposure in childhood (age <21 years).Methods In this analysis of historical cohort studies, we pooled eligible cohorts reported up to June 30, 2014. We evaluated leukaemia and myeloid malignancy outcomes in these cohorts with the relevant International Classification of Diseases and International Classification of Diseases for Oncology definitions. The cohorts included had not been treated for malignant disease, had reported at least five cases of the relevant haematopoietic neoplasms, and estimated individual active bone marrow (ABM) doses. We restricted analysis to individuals who were younger than 21 years at first irradiation who had mean cumulative ABM doses of less than 100 mSv. Dose-response models were fitted by use of Poisson regression. The data were received in fully anonymised form by the statistical analyst.Findings We identified nine eligible cohorts from Canada, France, Japan, Sweden, the UK, and the USA, including 262 573 people who had been exposed to less than 100 mSv enrolled between June 4, 1915, and Dec 31, 2004. Mean follow-up was 19·63 years (SD 17·75) and mean cumulative ABM dose was 19·6 mSv (SD 22·7). 154 myeloid malignancies were identified (which included 79 acute myeloid leukaemias, eight myelodysplastic syndromes, and 36 chronic myeloid leukaemias, in addition to other unspecified myeloid malignancies) and 40 acute lymphoblastic leukaemias, with 221 leukaemias (including otherwise unclassified leukaemias but excluding chronic lymphocytic leukaemia) identified overall. The fitted relative risks at 100 mSv were 3·09 (95% CI 1·41-5·92; p trend=0·008) for acute myeloid leukaemia and myelodysplastic syndromes combined, 2·56 (1·09-5·06; p trend=0·033) for acute myeloid leukaemia, and 5·66 (1·35-19·71; p trend=0·023) for acute lymphoblastic leukaemia. There was no clear dose-response for chronic myeloid leukaemia, which had a relative risk at 100 mSv of 0·36 (0·00-2·36; p trend=0·394). There were few indications of between-cohort heterogeneity or departure from linearity. For acute myeloid leukaemia and myelodysplastic syndromes combined and for acute lymphoblastic leukaemia, the dose-responses remained significant for doses of less than 50 mSv. Excess absolute risks at 100 mSv were in the range of 0·1-0·4 cases or deaths per 10 000 person-years.Interpretation The risks of acute myeloid leukaemia and acute lymphoblastic leukaemia were significantly increased after cumulative doses of ionising radiation of less than 100 mSv in childhood or adolescence, with an excess risk also apparent for cumulative radiation doses of less than 50 mSv for some endpoints. These findings support an increased risk of leukaemia associated with low-dose exposure to radiation and imply that the current system of radiological protection is prudent and not overly protective.Funding National Cancer Institute Intramural Research Program, National Cancer Institute, and US National Institutes for Health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Indeed, our leukemia risk estimate is compatible with those derived in a recent combined analysis of data on individuals exposed before the age of 21 years and ABM dose <100 mGy (ERR/100 mGy 0.84–4.66, depending on leukemia subtype)38.”
From Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults (2023) · cites this paper as [38]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2005) · Springer eBooks · doi:10.1007/0-387-27255-0_9 · Cited by 20,333
Brown, R. A., Hastie, T. J., & Tibshirani, R. J. (1991) · Biometrics · doi:10.2307/2532174 · Cited by 8,263
Koyak, R. A., Hastie, T. J., & Tibshirani, R. J. (1991) · Journal of the American Statistical Association · doi:10.2307/2290538 · Cited by 7,717
Recommendations of the International Commission on Radiological Protection
(1961) · Postgraduate Medical Journal · doi:10.1136/pgmj.37.425.168-b · Cited by 5,868
Hossfeld, D. K. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf146 · Cited by 4,614
Pearce, M. S., Salotti, J. A., Little, M. P., McHugh, K., Lee, C., Kim, K. P., Howe, N. L., Ronckers, C. M., Rajaraman, P., Craft, A. W., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60815-0 · Cited by 3,735
Self-citationPreface, Executive Summary and Glossary
(2007) · Annals of the ICRP · doi:10.1016/j.icrp.2007.10.003 · Cited by 2,116
Recommendations of the International Commission on Radiological Protection, ICRP Publication 26
Icrp (1977) · Medical Entomology and Zoology · Cited by 1,785
Measurement error in nonlinear models: a modern perspective
Carroll, R. J. (2006) · Cited by 1,374
Benefits and costs, an eternal balance
Dixon, A. K. (2007) · Annals of the ICRP · doi:10.1016/j.icrp.2007.09.001 · Cited by 1,355
Cited by
Sorted by citations
Bosch de Basea, M., Thierry-Chef, I., Harbron, R., Hauptmann, M., Byrnes, G., Bernier, M.-O., Le Cornet, L., Dabin, J., Ferro, G., Istad, T. S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02620-0 · Cited by 349
Self-citationHauptmann, M., Daniels, R. D., Cardis, E., Cullings, H. M., Kendall, G. M., Laurier, D., Linet, M. S., Little, M. P., Lubin, J. H., Preston, D. L., et al. (2020) · JNCI Monographs · doi:10.1093/jncimonographs/lgaa010 · Cited by 181
Self-citationAssociation of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism
Kitahara, C. M., de González, A. B., Bouville, A. C., Brill, A. B., Doody, M. M., Melo, D. R., Simon, S. L., Sosa, J. A., Tülchinsky, M., Villoing, D., et al. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.0981 · Cited by 174
Self-citationPasqual, E., Schonfeld, S. J., Morton, L. M., Villoing, D., Lee, C., de González, A. B., & Kitahara, C. M. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.01841 · Cited by 149
Self-citationX-ray-Based Techniques to Study the Nano–Bio Interface
Sánchez-Cano, C., Álvarez‐Puebla, R. A., Abendroth, J. M., Beck, T., Blick, R. H., Cao, Y., Caruso, F., Chakraborty, I., Chapman, H. N., Chen, C., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c09563 · Cited by 128
Keeping the ICRP recommendations fit for purpose
Clement, C. H., Rühm, W., Harrison, J. D., Applegate, K. E., Cool, D. A., Larsson, C. ‐., Cousins, C., Lochard, J., Bouffler, S. D., Cho, K.-W., et al. (2021) · Journal of Radiological Protection · doi:10.1088/1361-6498/ac1611 · Cited by 125
Rühm, W., Laurier, D., & Wakeford, R. (2021) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2021.503436 · Cited by 94
Self-citationMedical Imaging and Pediatric and Adolescent Hematologic Cancer Risk
Smith‐Bindman, R., Alber, S. A., Kwan, M. L., Pequeno, P., Bolch, W. E., Bowles, E. J. A., Greenlee, R. T., Stout, N. K., Weinmann, S. A., Moy, L. M., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2502098 · Cited by 91
Lee, K. H., Lee, S., Park, J. H., Lee, S.-S., Kim, H. Y., Lee, W. J., Cha, E. S., Kim, K. P., Lee, W., Lee, J. Y., et al. (2021) · JAMA Surgery · doi:10.1001/jamasurg.2020.6357 · Cited by 91
Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review
Onyije, F. M., Olsson, A. C., Baaken, D., Erdmann, F., Stanulla, M., Wollschläger, D., & Schüz, J. (2022) · Cancers · doi:10.3390/cancers14020382 · Cited by 96
Brenner, A. V., Sugiyama, H., Preston, D. L., Sakata, R., French, B. C., Sadakane, A., Cahoon, E. K., Utada, M., Mabuchi, K., & Ozasa, K. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-019-00599-y · Cited by 78
Self-citationAreas of research to support the system of radiological protection
Laurier, D., Rühm, W., Paquet, F., Applegate, K. E., Cool, D. A., Clement, C. H., & the International Commission on Radiological Protection (ICRP) (2021) · Radiation and Environmental Biophysics · doi:10.1007/s00411-021-00947-1 · Cited by 77
Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk
Sud, A., Chattopadhyay, S., Thomsen, H., Sundquist, K., Sundquist, J., Houlston, R. S., & Hemminki, K. (2019) · Blood · doi:10.1182/blood.2019001362 · Cited by 72
Little, M. P., Wakeford, R., Bouffler, S. D., Abalo, K., Hauptmann, M., Hamada, N., & Kendall, G. M. (2021) · Environment International · doi:10.1016/j.envint.2021.106983 · Cited by 68
Self-citationLaurier, D., Billarand, Y., Klokov, D. Y., & Leuraud, K. (2023) · Journal of Radiological Protection · doi:10.1088/1361-6498/acdfd7 · Cited by 66
Exposure to nitrate from drinking water and the risk of childhood cancer in Denmark
Stayner, L. T., Schullehner, J., Semark, B. D., Jensen, A. S., Trabjerg, B. B., Pedersen, M., Olsen, J., Hansen, B., Ward, M. H., Jones, R. R., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106613 · Cited by 64
Ngoc, L. T. N., Park, D., & Lee, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010097 · Cited by 56
Risk Factors for Childhood Leukemia: Radiation and Beyond
Schmidt, J.-A., Hornhardt, S., Erdmann, F., Sánchez-García, I., Fischer, U., Schüz, J., & Ziegelberger, G. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.805757 · Cited by 61
Overview of radon gas in groundwater around the world: Health effects and treatment technologies
Manawi, Y. M., Hassan, A. E., Atieh, M. A., & Lawler, J. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2024.122176 · Cited by 47
Interactions Between Gut Microbiota and Acute Childhood Leukemia
Wen, Y., Jin, R., & Chen, H. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01300 · Cited by 48
Profiling of gut microbial dysbiosis in adults with myeloid leukemia
Yu, D., Yu, X.-M., Ye, A., Xu, C., Li, X., Geng, W., & Zhu, L. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13193 · Cited by 44
Low-Dose Non-Targeted Effects and Mitochondrial Control
Averbeck, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411460 · Cited by 51
Gilbert, E. S., Little, M. P., Preston, D. L., & Stram, D. O. (2020) · JNCI Monographs · doi:10.1093/jncimonographs/lgaa004 · Cited by 42
Self-citationChildhood cancer risks estimates following CT scans: an update of the French CT cohort study
Foucault, A., Ancelet, S., Dreuil, S., Caër-Lorho, S., Ducou Le Pointe, H., Brisse, H., Chateil, J.-F., Lee, C., Leuraud, K., & Bernier, M.-O. (2022) · European Radiology · doi:10.1007/s00330-022-08602-z · Cited by 39
Self-citationOptimisation of Radiological Protection in Digital Radiology Techniques for Medical Imaging
154, I. P. (2023) · Annals of the ICRP · doi:10.1177/01466453231210646 · Cited by 37
Cancer incidence and mortality in the USA Astronaut Corps, 1959–2017
Reynolds, R. J., Little, M. P., Day, S. M., Charvat, J. M., Blattnig, S. R., Huff, J. L., & Patel, Z. S. (2021) · Occupational and Environmental Medicine · doi:10.1136/oemed-2020-107143 · Cited by 44
Self-citationNguyen, N. C., Anigati, E. M., Desai, N. B., & Öz, O. K. (2024) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2024.05.002 · Cited by 33
Radiation epidemiology and health effects following low-level radiation exposure
Boice, J. D., Held, K. D., & Shore, R. E. (2019) · Journal of Radiological Protection · doi:10.1088/1361-6498/ab2f3d · Cited by 31
Hamada, N. (2023) · Radiation Research · doi:10.1667/rade-23-00030.1 · Cited by 31
Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
Liu, N., Peng, Y., Zhong, X., Ma, Z., He, S., Li, Y., Zhang, W., Gong, Z., & Yao, Z. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00939-z · Cited by 28
Chauhan, V., Beaton, D., Hamada, N., Wilkins, R. C., Burtt, J. J., Leblanc, J. E., Cool, D. A., Garnier‐Laplace, J., Laurier, D., Le, Y., et al. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.2020363 · Cited by 31
External background ionizing radiation and childhood cancer: Update of a nationwide cohort analysis
Mazzei, A., Folly, C. L., Kreis, C., Ammann, R. A., Adam, C. J. M., Brack, E. K., Egger, M., Kuehni, C. E., & Spycher, B. D. (2021) · Journal of Environmental Radioactivity · doi:10.1016/j.jenvrad.2021.106734 · Cited by 26
Patient‐specific radiation risk‐based tube current modulation for diagnostic CT
Klein, L., Liu, C., Steidel, J., Enzmann, L., Knaup, M., Sawall, S., Maier, A., Lell, M., Maier, J., & Kachelrieß, M. (2022) · Medical Physics · doi:10.1002/mp.15673 · Cited by 25
Frederiksen, L. E., Erdmann, F., Wesseling, C., Winther, J. F., & Mora, A. M. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108827 · Cited by 25
Maintenir les recommandations de la CIPR adaptées aux besoins
Clement, C. H., Rühm, W., Harrison, J. D., Applegate, K. E., Cool, D. A., Larsson, C. ‐., Cousins, C., Lochard, J., Bouffler, S. D., Cho, K., et al. (2022) · Radioprotection · doi:10.1051/radiopro/2022010 · Cited by 24
Guo, J., Liu, N., Ma, Z., Gong, Z.-J., Liang, Y., Cheng, Q., Zhong, X., & Yao, Z. (2022) · Dose-Response · doi:10.1177/15593258221105695 · Cited by 23
Allodji, R. S., Tucker, M. A., Hawkins, M. M., Deley, M. L., Veres, C., Weathers, R. E., Howell, R. M., Winter, D., Haddy, N., Rubino, C., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33361 · Cited by 23
Self-citationA Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure
Little, M. P., Bаzyка, D., de González, A. B., Brenner, A. V., Chumak, V. V., Cullings, H. M., Daniels, R. D., French, B. C., Grant, E. J., Hamada, N., et al. (2024) · Radiation Research · doi:10.1667/rade-24-00021.1 · Cited by 23
Self-citationAdverse outcome pathways, key events, and radiation risk assessment
Preston, R. J., Rühm, W., Azzam, E. I., Boice, J. D., Bouffler, S. D., Held, K. D., Little, M. P., Shore, R. E., Shuryak, I., & Weil, M. M. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1853847 · Cited by 22
Self-citationBerlivet, J., Hémon, D., Cléro, É., Ielsch, G., Laurier, D., Faure, L., Clavel, J., & Goujon, S. (2021) · Journal of Environmental Radioactivity · doi:10.1016/j.jenvrad.2021.106613 · Cited by 21
Opportunities and Challenges for Gut Microbiota in Acute Leukemia
Ma, T., Chen, Y., Li, L., & Zhang, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.692951 · Cited by 21
Gault, N., Verbiest, T., Badie, C., Roméo, P., & Bouffler, S. D. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1569777 · Cited by 20
“Black bone”: the new backbone in CAD/CAM-assisted craniosynostosis surgery?
Lethaus, B., Gruichev, D., Gräfe, D., Bartella, A. K.-H., Hahnel, S., Yovev, T., Pausch, N. C., & Krause, M. (2020) · Acta Neurochirurgica · doi:10.1007/s00701-020-04445-z · Cited by 20
Mazzei, A., Folly, C. L., Coste, A., Wakeford, R., Little, M. P., Raaschou‐Nielsen, O., Kendall, G. M., Hémon, D., Nikkilä, A., Spix, C., et al. (2019) · Journal of Radiological Protection · doi:10.1088/1361-6498/ab5a38 · Cited by 19
Self-citationAge effects on radiation response: summary of a recent symposium and future perspectives
Little, M. P., Brenner, A. V., Grant, E. J., Sugiyama, H., Preston, D. L., Sakata, R., COLOGNE, J. B., Velazquez‐Kronen, R., Utada, M., Mabuchi, K., et al. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2022.2063962 · Cited by 19
Self-citationLittle, M. P., Wakeford, R., Zablotska, L. B., Borrego, D., Griffin, K., Allodji, R. S., de Vathaire, F., Lee, C., Brenner, A. V., Miller, J. S., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02387-8 · Cited by 19
Self-citationEnvironmental Agents and Childhood Cancer
Erdmann, F., Ghantous, A., & Schüz, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-409548-9.11725-7 · Cited by 19
Wei, Y., Gong, Y., Wei, S., Chen, Y., Cui, J. T., Lin, X., Yu, Y., Yan, H., Qin, H., & Yi, L. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01400-7 · Cited by 18
Rational Usage of Fracture Imaging in Children and Adolescents
Kraus, R., & Dresing, K. (2023) · Diagnostics · doi:10.3390/diagnostics13030538 · Cited by 17
Lymphoma and multiple myeloma in cohorts of persons exposed to ionising radiation at a young age
Little, M. P., Wakeford, R., Zablotska, L. B., Borrego, D., Griffin, K., Allodji, R. S., de Vathaire, F., Lee, C., Brenner, A. V., Miller, J. S., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01284-4 · Cited by 17
Self-citationOn-site CAD templates reduce surgery time for complex craniostenosis repair in infants: a new method
Lehner, M., Wendling‐Keim, D. S., Kunz, M., Deininger, S., Zundel, S., Peraud, A., & Mast, G. (2020) · Child s Nervous System · doi:10.1007/s00381-019-04474-9 · Cited by 17
Aldoss, I. T., Douer, D., & Pullarkat, V. A. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.06.001 · Cited by 16
Abalo, K., Malekzadeh-Milani, S. G., Hascoët, S., Dreuil, S., Feuillet, T., Cohen, S., Dauphin, C., Filippo, S. D., Douchin, S., Godart, F. R., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-048576 · Cited by 16
The Evidence for Excess Risk of Cancer and Non-Cancer Disease at Low Doses and Dose Rates
Simon, S. L., Kendall, G. M., Bouffler, S. D., & Little, M. P. (2022) · Radiation Research · doi:10.1667/rade-22-00132.1 · Cited by 15
Self-citationBaqays, A., Zenke, J. K., Campbell, S., Johannsen, W., Rashid, M., Seikaly, H. R., & El‐Hakim, H. (2021) · Journal of Otolaryngology - Head and Neck Surgery · doi:10.1186/s40463-021-00549-3 · Cited by 14
Erdmann, F., Raaschou‐Nielsen, O., Hvidtfeldt, U. A., Ketzel, M., Brandt, J. G., Khan, J., Schüz, J., & Sørensen, M. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113180 · Cited by 14
Bunch, K. J., Kendall, G. M., Stiller, C. A., Vincent, T. J., & Murphy, M. F. G. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0469-7 · Cited by 14
Therapy-Related Myeloid Neoplasms in 109 Patients Following Radiation Monotherapy
Patel, A. A., Rojek, A. E., Drazer, M. W., Weiner, H., Godley, L. A., Beau, M. M. L., & Larson, R. A. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021004964 · Cited by 17
Laurier, D., Billarand, Y., Klokov, D. Y., & Leuraud, K. (2023) · Radioprotection · doi:10.1051/radiopro/2023036 · Cited by 13
Tao, S. M., Wang, L.-L., Li, M., Wang, J., Gu, H. M., & Zhang, L. J. (2024) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2024.108517 · Cited by 13
Lifetime attributable risk of cancer incidence and mortality in routine digital radiology procedures
Zangeneh, M., Deevband, M. R., & Mohsenzadeh, B. (2020) · Clinical Imaging · doi:10.1016/j.clinimag.2020.08.006 · Cited by 13
Birth characteristics and childhood leukemia in Switzerland: a register-based case–control study
Lupatsch, J. E., Kreis, C., Konstantinoudis, G., Ansari, M., Kuehni, C. E., & Spycher, B. D. (2021) · Cancer Causes & Control · doi:10.1007/s10552-021-01423-3 · Cited by 13
Grandt, C. L., Brackmann, L. K., Poplawski, A., Schwarz, H., Hummel-Bartenschlager, W., Hankeln, T., Kraemer, C., Marini, F., Zahnreich, S., Schmitt, I. M., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00520-6 · Cited by 13
Mukkamalla, S. K. R., Taneja, A., Malipeddi, D., & Master, S. R. (2021) · StatPearls · Cited by 13
Bellamy, M. B., Bernstein, J. L., Cullings, H. M., French, B. C., Grogan, H. A., Held, K. D., Little, M. P., & Tekwe, C. D. (2024) · International Journal of Radiation Biology · doi:10.1080/09553002.2024.2381482 · Cited by 12
Self-citationRadium levels in Brazil nuts: A review of the literature
Koeder, C., & Keller, M. (2024) · Nutrition Bulletin · doi:10.1111/nbu.12717 · Cited by 12
Integration of multi-omics and benchmark dose modeling to support adverse outcome pathways
Vuong, N. Q., Khilji, S., Williams, A., Adam, N., Flores, D., Fulton, K. M., Baay, I., Twine, S. M., Meier, M. J., Kumarathasan, P., et al. (2025) · International Journal of Radiation Biology · doi:10.1080/09553002.2024.2442694 · Cited by 12
for the Swiss Paediatric Oncology Group, Konstantinoudis, G., the Swiss National Cohort Study Group, Schuhmacher, D., Ammann, R. A., Diesch, T., Kuehni, C. E., & Spycher, B. D. (2020) · International Journal of Health Geographics · doi:10.1186/s12942-020-00211-7 · Cited by 12
Tariq, H., Slonim, L. B., Coty‐Fattal, Z., Alikhan, M. B., Segal, J. P., Gurbuxani, S. K., Helenowski, I., Zhang, H., SUKHANOVA, M. J., Lu, X. Y., et al. (2022) · British Journal of Haematology · doi:10.1111/bjh.18154 · Cited by 12
Minimum latency effects for cancer associated with exposures to radiation or other carcinogens
Little, M. P., Eidemüller, M., Kaiser, J. C., & Apostoaei, A. I. (2024) · British Journal of Cancer · doi:10.1038/s41416-023-02544-z · Cited by 11
Self-citationJoseph, N., & Kolok, A. S. (2022) · GeoHealth · doi:10.1029/2021gh000548 · Cited by 12
Microbiota, Diet and Acute Leukaemia: Tips and Tricks on Their Possible Connections
Furci, F., Cicero, N., Allegra, A., & Gangemi, S. (2023) · Nutrients · doi:10.3390/nu15194253 · Cited by 11
Erdman, L., Rickard, M., Drysdale, E., Skreta, M., Hua, S. B. Z., Sheth, K. R., Alvarez, D., Velaer, K. N., Chua, M. E., Santos, J. D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-72271-9 · Cited by 10
Space exploration and cancer: the risks of deeper space adventures
Muhsen, I. N., Zubair, A. C., Niederwieser, T., & Hashmi, S. K. (2024) · Leukemia · doi:10.1038/s41375-024-02298-4 · Cited by 11
Gu, Y., Wang, J., Wang, Y., Xu, C., Liu, Y., Du, L., Wang, Q., Ji, K., He, N., Zhang, M., et al. (2022) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2022.01.001 · Cited by 41
Little, M. P., Hamada, N., & Zablotska, L. B. (2024) · Scientific Reports · doi:10.1038/s41598-024-56967-6 · Cited by 9
Self-citationSegal‐Engelchin, D., & Shvarts, S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207388 · Cited by 9
Erdmann, F., Hvidtfeldt, U. A., Feychting, M., Sørensen, M., & Raaschou‐Nielsen, O. (2020) · International Journal of Cancer · doi:10.1002/ijc.33402 · Cited by 9
Hafner, L., Walsh, L., & Rühm, W. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2022.2117871 · Cited by 9
Chauhan, V., Beaton, D., Tollefsen, K. E., Preston, R. J., Burtt, J. J., Leblanc, J. E., Hamada, N., Azzam, E. I., Armant, O., Bouffler, S. D., et al. (2024) · International Journal of Radiation Biology · doi:10.1080/09553002.2024.2348072 · Cited by 8
Zablotska, L. B., Little, M. P., & Hamada, N. (2024) · Radiation Research · doi:10.1667/rade-00230.1 · Cited by 8
Self-citationTypes of Evidence Needed to Assess the Clinical Value of Diagnostic Imaging
Stewart, C., Davenport, M. S., Miglioretti, D. L., & Smith‐Bindman, R. (2024) · NEJM Evidence · doi:10.1056/evidra2300252 · Cited by 8
Muresanu, C., & Егорович, Х. С. (2022) · DNA and Cell Biology · doi:10.1089/dna.2021.1118 · Cited by 9
Current Challenges in Hematology: Awareness, Prevention, Equity
Kaye, D., & Isidori, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.653020 · Cited by 7
Cytogenetic follow-up studies on humans with internal and external exposure to ionizing radiation
Balajee, A. S., Livingston, G. K., Escalona, M. B., Ryan, T. L., Goans, R. E., & Iddins, C. J. (2021) · Journal of Radiological Protection · doi:10.1088/1361-6498/ac125a · Cited by 7
Linet, M. S., Davis, P. B., & Brink, J. A. (2021) · Radiology · doi:10.1148/radiol.2021210665 · Cited by 7
Self-citationOsteoclastic craniectomy for scaphocephaly in infants results in physiological head shapes
Lehner, M., Ferrari-von Klot, F., Zundel, S., & Wendling-Keim, D. (2019) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2019.10.006 · Cited by 6
Medical imaging utilization and associated radiation exposure in children with down syndrome
Marlow, E. C., Ducore, J. M., Kwan, M. L., Bowles, E. J. A., Greenlee, R. T., Pole, J. D., Rahm, A. K., Stout, N. K., Weinmann, S. A., Smith‐Bindman, R., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289957 · Cited by 6
Preleukemic Fusion Genes Induced via Ionizing Radiation
Košík, P., Škorvaga, M., & Belyaev, I. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076580 · Cited by 6
A generalisation of the method of regression calibration
Little, M. P., Hamada, N., & Zablotska, L. B. (2023) · Scientific Reports · doi:10.1038/s41598-023-42283-y · Cited by 6
Self-citationBaqays, A., Johannsen, W., Rashid, M., Jaffal, H., Hicks, A., Jeffery, C. C., Seikaly, H. R., & El‐Hakim, H. (2020) · Otolaryngology · doi:10.1177/0194599820970950 · Cited by 6
Milder, C. M., Kendall, G. M., Arsham, A., Schöllnberger, H., Wakeford, R., Cullings, H. M., & Little, M. P. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1867326 · Cited by 6
Self-citationBaqays, A., Rashid, M., Johannsen, W., Seikaly, H. R., & El‐Hakim, H. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-041591 · Cited by 6
An, J. J., Choi, M., Chen, Y., Teng, M. S., & van Gerwen, M. A. G. (2025) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2025.2626 · Cited by 5
Low-Dose Radiation Risks of Lymphohematopoietic Cancer Mortality in U.S. Shipyard Workers
Tao, X. G., Curriero, F. C., & Mahesh, M. (2022) · Radiation Research · doi:10.1667/rade-22-00092.1 · Cited by 5
Radiation exposure in multiple hereditary exostoses: A retrospective review
Farrell, N. D., Dooley, J. H., Sheffer, B. W., Sawyer, J. R., & Kelly, D. M. (2023) · Journal of Orthopaedics · doi:10.1016/j.jor.2023.05.004 · Cited by 5
Restier-Verlet, J., Ferlazzo, M. L., Granzotto, A., Al-Choboq, J., Bellemou, C., Estavoyer, M., Lecomte, F., Bourguignon, M., Pujo-Menjouet, L., & Foray, N. (2024) · Cells · doi:10.3390/cells13201703 · Cited by 8
Hair loss due to scalp ringworm irradiation in childhood: health and psychosocial risks for women
Hoffer, L., Shvarts, S., & Segal‐Engelchin, D. (2020) · Israel Journal of Health Policy Research · doi:10.1186/s13584-020-00393-2 · Cited by 5
Adel, M., Khedr, R. A., Sayed, A. A., Shalaby, L., Diab, A. A., Yahia, A., ElAnany, M. G., Lehmann, L., Ahmed, S., Aziz, R. K., et al. (2025) · Children · doi:10.3390/children12091176 · Cited by 4
Bana, M. H. E., Abdelgawad, M. H., Eltahawy, N. A., Algeda, F. R., & Elsayed, T. M. (2024) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2024.111424 · Cited by 4
Metadata
- Authors
- Little, M. P., Wakeford, R., Borrego, D., French, B., Zablotska, L. B., Adams, M. J., Allodji, R., de Vathaire, F., Lee, C., Brenner, A. V., Miller, J. S., Campbell, D., Pearce, M. S., Doody, M. M., Holmberg, E., Lundell, M., Sadetzki, S., Linet, M. S., & Berrington de González, A.
- Affiliations
- National Institutes of Health (US)
- University of Manchester (GB)
- National Cancer Institute (US)
- Radiation Effects Research Foundation (JP)
- University of California, San Francisco (US)
- University of Rochester Medicine (US)
- Inserm (FR)
- Information Management Services (US)
- National Institute for Health and Care Research (GB)
- Sahlgrenska University Hospital (SE)
- Karolinska University Hospital (SE)
- Tel Aviv University (IL)
- Corresponding author
- Little, Mark P
- ORCID
- Venue
- The Lancet Haematology
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 5
- Issue
- 8
- Pages
- e346-e358
- ISSN
- 2352-3026 (ISSN-L)
- PMC
- PMC6130888
- OpenAlex
- W2883741998
- Cited by
- 152
- References
- 41
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 23 · 2023: 17 · 2022: 23 · 2021: 30 · 2020: 21 · 2019: 13 · 2018: 3
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Lancet Haematology (acceptedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Funders
- National Academy of Sciences
- Foundation for the National Institutes of Health (R01CA197422, R03CA188614)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Ministry of Health, Labour and Welfare
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiation Dose and Imaging
- Physical Sciences › Physics and Astronomy › Radiation › Radioactivity and Radon Measurements
- Keywords
- pediatric radiation exposure, low-dose radiation, leukemia, myeloid neoplasms, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic syndrome, dose-response relationship, radiation-induced cancer risk, historical cohort study, pooled analysis
- MeSH terms
- Adult, Aged, Child, Female, Humans, Leukemia, Male, Middle Aged, Neoplasms, Radiation-Induced, Radiation Dosage, Risk, Cohort Studies, Bone Marrow Neoplasms, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
