The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process
Open accessAbstract
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to provide guidance for clinicians caring for children with PIMS-TS. A three-phase online Delphi process and virtual consensus meeting sought consensus over the investigation, management, and research priorities from multidisciplinary clinicians caring for children with PIMS-TS. We used 140 consensus statements to derive a consensus management pathway that describes the initial investigation of children with suspected PIMS-TS, including blood markers to help determine the severity of disease, an echocardiogram, and a viral and septic screen to exclude other infectious causes of illness. The importance of a multidisciplinary team in decision making for children with PIMS-TS is highlighted throughout the guidance, along with the recommended treatment options, including supportive care, intravenous immunoglobulin, methylprednisolone, and biological therapies. These include IL-1 antagonists (eg, anakinra), IL-6 receptor blockers (eg, tocilizumab), and anti-TNF agents (eg, infliximab) for children with Kawasaki disease-like phenotype and non-specific presentations. Use of a rapid online Delphi process has made it possible to generate a national consensus pathway in a timely and cost-efficient manner in the middle of a global pandemic. The consensus statements represent the views of UK clinicians and are applicable to children in the UK suspected of having PIMS-TS. Future evidence will inform updates to this guidance, which in the interim provides a solid framework to support clinicians caring for children with PIMS-TS. This process has directly informed new PIMS-TS specific treatment groups as part of the adaptive UK RECOVERY trial protocol, which is the first formal randomised controlled trial of therapies for PIMS-TS globally.
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Cites
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Cited by
Reporting guidelines for Delphi techniques in health sciences: A methodological review
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Metadata
- Authors
- Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., Kaleem, M., Tulloh, R., Peters, M. J., Almond, S., Davis, P. J., Levin, M., Tometzki, A., Faust, S. N., Knight, M., Kenny, S., Agbeko, R., Aragon, O., Baird, J., Bamford, A., Bereford, M., Bharucha, T., Brogan, P., Butler, K., Carroll, E., Cathie, K., Chikermane, A., Christie, S., Clark, M., Deri, A., Doherty, C., Drysdale, S., Duong, P., Durairaj, S., Emonts, M., Evans, J., Fraser, J., Hackett, S., Hague, R., Heath, P., Herberg, J., Ilina, M., Jay, N., Kelly, D., Kerrison, C., Kraft, J., Leahy, A., Linney, M., Lyall, H., McCann, L., McMaster, P., Miller, O., O'Riordan, S., Owens, S., Pain, C., Patel, S., Pathan, N., Pauling, J., Porter, D., Prendergast, A., Ravi, K., Riorden, A., Roderick, M., Scholefield, B. R., Semple, M. G., Sen, E., Shackley, F., Sinha, I., Tibby, S., Verganano, S., Welch, S. B., Wilkinson, N., Wood, M., & Yardley, I.
- Venue
- The Lancet Child & Adolescent Health
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 5
- Issue
- 2
- Pages
- 133-141
- ISSN
- 2352-4642 (ISSN-L)
- OpenAlex
- W3087378474
- Cited by
- 336
- References
- 21
- FWCI
- 55.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. https://app.cochat.ai/papers/10.1016/s2352-4642(20)30304-7
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- Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., Kaleem, M., Tulloh, R., Peters, M. J., Almond, S., Davis, P. J., Levin, M., Tometzki, A., Faust, S. N., Knight, M., Kenny, S., Agbeko, R., Aragon, O., Baird, J., . . . Yardley, I. (2021). A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. The Lancet Child & Adolescent Health. https://doi.org/10.1016/s2352-4642(20)30304-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
