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Cited by 281

The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.

Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement

Open access
Eslam, Mohammed, Alkhouri, Naim, Vajro, Pietro, Baumann, Ulrich, Weiss, Ram, Socha, Piotr, Marcus, Claude, Lee, Way Seah, Kelly, Deirdre, Porta, Gilda, El-Guindi, Mohamed A, Alisi, Anna, Mann, Jake P, Mouane, Nezha, Baur, Louise A, Dhawan, Anil, George, Jacob·2021·The Lancet Gastroenterology & Hepatology

Abstract

The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for both adults and children. The definition is most problematic for children, for whom alcohol consumption is usually not a concern. This problematic definition has prompted a consensus to rename and redefine adult NAFLD associated with metabolic dysregulation to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Similarities, distinctions, and differences exist in the causes, natural history, and prognosis of fatty liver diseases in children compared with adults. In this Viewpoint we, an international panel, propose an overarching framework for paediatric fatty liver diseases and an age-appropriate MAFLD definition based on sex and age percentiles. The framework recognises the possibility of other coexisting systemic fatty liver diseases in children. The new MAFLD diagnostic criteria provide paediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, and they align with a definition that is valid across the lifespan.

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Metadata

Authors
Eslam, M., Alkhouri, N., Vajro, P., Baumann, U., Weiss, R., Socha, P., Marcus, C., Lee, W. S., Kelly, D., Porta, G., El-Guindi, M. A., Alisi, A., Mann, J. P., Mouane, N., Baur, L. A., Dhawan, A., & George, J.
Venue
The Lancet Gastroenterology & Hepatology
Publisher
Elsevier BV
Published
2021-10
Volume
6
Issue
10
Pages
864-873
ISSN
  • 2468-1156 (ISSN-L)
  • 2468-1253
OpenAlex
W3187910690
Cited by
281
References
139
FWCI
28.80
Type
journal article
Language
en
Open access
green

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The paper
Eslam, M., Alkhouri, N., Vajro, P., Baumann, U., Weiss, R., Socha, P., Marcus, C., Lee, W. S., Kelly, D., Porta, G., El-Guindi, M. A., Alisi, A., Mann, J. P., Mouane, N., Baur, L. A., Dhawan, A., & George, J. (2021). Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement. The Lancet Gastroenterology & Hepatology. https://doi.org/10.1016/s2468-1253(21)00183-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.