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Systematic SARS-CoV-2 screening in cerebrospinal fluid during the COVID-19 pandemic
Open accessAbstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged since December, 2019, and spread worldwide, causing the COVID-19 pandemic. Despite COVID-19 being a respiratory tract infection, the pathophysiology in both adults and children is incompletely understood. Neurological signs and symptoms—from headache to meningitis—have been reported in hospitalised patients.1,2 SARS-CoV-2 can enter and replicate in neuronal cells in vitro,3 but the association between neurological manifestations and presence of SARS-CoV-2 in cerebrospinal fluid (CSF) has only been tested in a few cases, with one patient testing positive for SARS-CoV-2 in a case report4 and seven of seven patients testing negative in a case series.
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SARS-CoV-2 RNA is rarely identified in CSF samples of COVID-19 patients.
“SARS-CoV-2 RNA, however, is rarely identified in CSF samples of COVID-19 patients [158], and most cases of COVID-associated neurological symptoms are CSF-RT-PCR-negative, including encephalopathic patients [128, 137, 159].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [158]
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References 6 · Cited by 88
Metadata
- Authors
- Destras, G., Bal, A., Escuret, V., Morfin, F., Lina, B., & Josset, L.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Josset, Laurence
- Venue
- The Lancet Microbe
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 1
- Issue
- 4
- Pages
- e149
- ISSN
- 2666-5247 (ISSN-L)
- PMC
- PMC7289579
- OpenAlex
- W3035723992
- Cited by
- 88
- References
- 6
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 15 · 2021: 31 · 2020: 17
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Lancet Microbe (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Hospices Civils de Lyon
- Topics
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, cerebrospinal fluid, neurological symptoms, SARS-CoV-2 RNA detection, viral neuroinvasion, meningitis, headache, systematic screening
- MeSH terms
- COVID-19, SARS-CoV-2, Antibodies, Viral, Humans, Mass Screening, Pandemics
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