The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.
Extracellular matrix–integrin interactions in osteoblast function and tissue remodeling
Abstract
Previous work with cultured primary cells, from our group and from other laboratories, has shown that signals from extracellular matrix, transduced by integrins, play critical roles in regulating gene expression, tissue-specific differentiation, and survival of primary osteoblasts and fibroblasts. This summary will focus on our most recent work, dealing with the role of cell-extracellular matrix interactions and focal adhesion kinase in regulating cell survival in osteoblasts and fibroblasts, and the role of beta1 integrins in tissue organization and remodeling in bone.
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“Osteoblasts make interactions with bone matrix by integrins, which recognize and bind to RGD and other sequences present in bone matrix proteins including osteopontin, fibronectin, collagen, osteopontin, and bone sialoprotein [130, 131].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [130]
Citations
Cites
(2020) · Elsevier eBooks · doi:10.1016/c2015-1-01622-2 · Cited by 1,683
Integrins: Emerging Paradigms of Signal Transduction
Schwartz, M. A., Schaller, M. D., & Ginsberg, M. H. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.003001 · Cited by 1,594
Principles of Bone Biology: By Bilezikian, Raisz and Rodan. Academic Press, London, U.K., 1996
Compston, J. E. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2431019.x · Cited by 1,370
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,208
Werb, Z., Tremble, P. M., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.2.877 · Cited by 1,059
Self-citationDamsky, C. H., & Werb, Z. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90100-q · Cited by 518
Self-citationIlić, D., Almeida, E. A. C., Schlaepfer, D. D., Dazin, P., Aizawa, S., & Damsky, C. H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.547 · Cited by 495
Self-citationMoursi, A. M., Globus, R. K., & Damsky, C. H. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.18.2187 · Cited by 380
Self-citationHuhtala, P., Humphries, M. J., McCarthy, J. B., Tremble, P. M., Werb, Z., & Damsky, C. H. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.3.867 · Cited by 374
Self-citationFibronectin regulates calvarial osteoblast differentiation
Moursi, A. M., Damsky, C. H., Lull, J., Zimmerman, D., Doty, S. B., Aota, S.-I., & Globus, R. K. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.6.1369 · Cited by 301
Self-citation
Research works printed but not linked: 1
- Globus R. K., Moursi A., Lopez V., and Damsky C. H. Role of fibronectin and adhesion receptors in osteoblast differentiation and function. Second International Conference on Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants. In: Davidovich, Z. and Mah, J., Eds. Boston: Harvard Society for the Advancement of Orthodontics; pp. 353–360.
Cited by
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
Hersel, U., Dahmen, C., & Kessler, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00343-0 · Cited by 2,582
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
Zreiqat, H., Howlett, C. R., Zannettino, A., Evans, P., Schulze‐Tanzil, G., Knabe, C., & Shakibaei, M. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10270 · Cited by 825
Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis
Shi, S., Robey, P. G., & Gronthos, S. (2001) · Bone · doi:10.1016/s8756-3282(01)00612-3 · Cited by 378
Phillippi, J. A., Miller, E., Weiss, L., Huard, J., Waggoner, A., & Campbell, P. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0520 · Cited by 361
Metadata
- Authors
- Damsky, C. H.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Damsky, C.H
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 25
- Issue
- 1
- Pages
- 95-96
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2002121674
- Cited by
- 187
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 5
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- extracellular matrix, integrins, osteoblasts, fibroblasts, focal adhesion kinase, beta1 integrin, cell survival, tissue remodeling, cell-matrix interactions, gene expression regulation
- MeSH terms
- Cell Survival, Extracellular Matrix, Fibroblasts, Humans, Osteoblasts, Protein-Tyrosine Kinases, Cell Adhesion Molecules, Integrins, Genes, p53, Bone Remodeling, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesion Kinase 1
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- CoChat. (2026). Citation check: Extracellular matrix–integrin interactions in osteoblast function and tissue remodeling. https://app.cochat.ai/papers/10.1016/s8756-3282(99)00106-4
- The paper
- Damsky, C. H. (1999). Extracellular matrix–integrin interactions in osteoblast function and tissue remodeling. Bone. https://doi.org/10.1016/s8756-3282(99)00106-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
