The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
DNA damage checkpoint kinases in cancer
Open accessAbstract
DNA damage response (DDR) pathway prevents high level endogenous and environmental DNA damage being replicated and passed on to the next generation of cells via an orchestrated and integrated network of cell cycle checkpoint signalling and DNA repair pathways. Depending on the type of damage, and where in the cell cycle it occurs different pathways are involved, with the ATM-CHK2-p53 pathway controlling the G1 checkpoint or ATR-CHK1-Wee1 pathway controlling the S and G2/M checkpoints. Loss of G1 checkpoint control is common in cancer through TP53, ATM mutations, Rb loss or cyclin E overexpression, providing a stronger rationale for targeting the S/G2 checkpoints. This review will focus on the ATM-CHK2-p53-p21 pathway and the ATR-CHK1-WEE1 pathway and ongoing efforts to target these pathways for patient benefit.
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Cites
1 retracted
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Cited by
Deng, S., Vlatkovic, T., Li, M., Zhan, T., Veldwijk, M. R., & Herskind, C. (2022) · Cancers · doi:10.3390/cancers14194874 · Cited by 62
G2 arrest primes hematopoietic stem cells for megakaryopoiesis
Garyn, C. M., Bover, O., Murray, J. W., Ma, J., Salas-Briceno, K., Ross, S. R., & Snoeck, H.-W. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114388 · Cited by 14
Ariyoshi, M., Yuge, R., Kitadai, Y., Shimizu, D., Miyamoto, R., Yamashita, K., Hiyama, Y., Takigawa, H., Urabe, Y., & Oka, S. (2024) · Cancers · doi:10.3390/cancers16183136 · Cited by 12
Kim, G. D. (2021) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2021.26.4.445 · Cited by 11
Smith, H. L., Willmore, E., Mukhopadhyay, A., Drew, Y., & Curtin, N. J. (2022) · Cancers · doi:10.3390/cancers14225559 · Cited by 9
Self-citation
Metadata
- Authors
- Smith, H. L., Southgate, H., Tweddle, D. A., & Curtin, N. J.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2020
- Volume
- 22
- Pages
- e2-e2
- ISSN
- 1462-3994 (ISSN-L)
- OpenAlex
- W3032979845
- Cited by
- 322
- References
- 192
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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