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Cited by 9Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene RegulationTGF-β signaling in diseases

Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases

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Zhang, Jie, Jiang, Yijing, Zhang, Zijian, Li, Shilin, Fan, Haowen, Gu, Jinhua, Mao, Renfang, Xu, Xiaohong·2024·Expert Reviews in Molecular Medicine
DOI 10.1017/erm.2024.24PMC PMC11488336
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Abstract

Repulsive guidance molecule b (RGMb), a glycosylphosphatidylinositol-anchored member of the RGM family, is initially identified as a co-receptor of bone morphogenetic protein (BMP) in the nervous system. The expression of RGMb is transcriptionally regulated by dorsal root ganglion 11 (DRG11), which is a transcription factor expressed in embryonic DRG and dorsal horn neurons and plays an important role in the development of sensory circuits. RGMb is involved in important physiological processes such as embryonic development, immune response, intercellular adhesion and tumorigenesis. Furthermore, RGMb is mainly involved in the regulation of RGMb–neogenin–Rho and BMP signalling pathways. The recent discovery of programmed death-ligand 2 (PD-L2)–RGMb binding reveals that the cell signalling network and functional regulation centred on RGMb are extremely complex. The latest report suggests that down-regulation of the PD-L2–RGMb pathway in the gut microbiota promotes an anti-tumour immune response, which defines a potentially effective immune strategy. However, the biological function of RGMb in a variety of human diseases has not been fully determined, and will remain an active research field. This article reviews the properties and functions of RGMb, focusing on its role under various physiological and pathological conditions.

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Sorted by citations

Authors
Zhang, J., Jiang, Y., Zhang, Z., Li, S., Fan, H., Gu, J., Mao, R., & Xu, X.
Affiliations
Nantong University (CN)
Corresponding author
  • Mao, Renfang
  • Xu, Xiaohong
ORCID
Venue
Expert Reviews in Molecular Medicine
Publisher
Cambridge University Press (CUP)
Published
2024
Volume
26
Pages
e24-e24
ISSN
1462-3994 (ISSN-L)
DOI
10.1017/erm.2024.24
PMC
PMC11488336
OpenAlex
W4403238385
Cited by
9
References
3
Citations by year
2026: 4 · 2025: 4 · 2024: 1
FWCI
0.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Expert Reviews in Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Nantong Municipal Commission of Health and Family Planning (QA2021033)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
RGMb, GPI-anchored proteins, BMP signaling, neogenin, Rho GTPase signaling, dorsal root ganglia, PD-L2, gut microbiota, antitumor immunity, carcinogenesis, cell-cell adhesion, immune response
MeSH terms
Animals, Humans, Neoplasms, Nerve Tissue Proteins, Signal Transduction, Cell Adhesion Molecules, Neuronal, GPI-Linked Proteins

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