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Cited by 15Bipolar Disorder and TreatmentTryptophan and brain disordersChemokine receptors and signaling

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Decreased percentage of CD4+ lymphocytes expressing chemokine receptors in bipolar disorder

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Barbosa, Izabela G., Rocha, Natalia P., Vieira, Erica L., Camkurt, Mehmet A., Huguet, Rodrigo B., Guimarães, Fabio T. L., de Brito-Melo, Gustavo E., Mendonça, Vanessa A., Bauer, Moises E., Teixeira, Antonio L.·2019·Acta Neuropsychiatrica
DOI 10.1017/neu.2019.5
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Abstract

Objective: Although accumulating evidence supports the hypothesis that immune/inflammatory mechanisms are associated with the pathophysiology of bipolar disorder (BD), data about the profile of chemokines (chemotactic cytokines) and chemokine receptors are still scarce. The current study was designed to evaluate the expression of chemokine receptors on lymphocytes of patients with BD in comparison with controls. Methods: Thirty-three patients with type I BD (N= 21 in euthymia;N= 6 in mania/hypomania;N= 6 in depression) and 22 age- and sex-matched controls were subjected to clinical evaluation and peripheral blood draw. The expression of chemokine receptors CCR3, CCR5, CXCR4, and CXCR3 on CD4+and CD8+lymphocytes was assessed by flow cytometry. Results: Patients with BD had decreased percentage of CD4+CXCR3+(p= 0.024), CD4+CCR3+(p= 0.042), and CD4+CCR5+(0.013) lymphocytes in comparison with controls. The percentage of both CD4+and CD8+lymphocytes expressing the chemokine receptor CXCR4 was similar in patients with BD and controls. Likewise, the percentages of CD8+CXCR3+, CD8+CCR3+, and CD8+CCR5+lymphocytes were similar in patients with BD and controls. Conclusion: Our findings reinforce the hypothesis that immune pathways, especially involving CD4+lymphocytes, are involved in the physiopathology of BD.

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Metadata

Authors
Barbosa, I. G., Rocha, N. P., Vieira, E. L., Camkurt, M. A., Huguet, R. B., Guimarães, F. T. L., de Brito-Melo, G. E., Mendonça, V. A., Bauer, M. E., & Teixeira, A. L.
Affiliations
  • Universidade Federal de Minas Gerais (BR)
  • The University of Texas Health Science Center at Houston (US)
  • Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
ORCID
Venue
Acta Neuropsychiatrica
Publisher
Cambridge University Press (CUP)
Published
2019-03-14
Volume
31
Issue
05
Pages
246-251
ISSN
  • 0924-2708 (ISSN-L)
  • 1601-5215
DOI
10.1017/neu.2019.5
OpenAlex
W2922405748
Cited by
15
References
2
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2020: 2
FWCI
1.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Acta Neuropsychiatrica (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • PUCRS Repository (Pontifical Catholic University of Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
bipolar disorder, chemokine receptors, CD4+ T cells, CD8+ T cells, CCR3, CCR5, CXCR3, CXCR4, immune dysfunction, inflammation, chemokines, mania, depression
MeSH terms
Adult, Aged, Bipolar Disorder, Female, Flow Cytometry, Humans, Male, Middle Aged, CD4-Positive T-Lymphocytes, Receptors, Chemokine

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CoChat. (2026). Citation check: Decreased percentage of CD4+ lymphocytes expressing chemokine receptors in bipolar disorder. https://app.cochat.ai/papers/10.1017/neu.2019.5
The paper
Barbosa, I. G., Rocha, N. P., Vieira, E. L., Camkurt, M. A., Huguet, R. B., Guimarães, F. T. L., de Brito-Melo, G. E., Mendonça, V. A., Bauer, M. E., & Teixeira, A. L. (2019). Decreased percentage of CD4+ lymphocytes expressing chemokine receptors in bipolar disorder. Acta Neuropsychiatrica. https://doi.org/10.1017/neu.2019.5