The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Aggravation of epilepsy by anti-epileptic drugs
Open accessAbstract
The possibility that so‐called anti‐epileptic drugs (AEDs) may aggravate epilepsy must always be borne in mind by the clinician. Many reports of such aggravation of seizures have been published. Most such reports are anecdotal and speculative, and suggest that many such reactions are idiosyncratic. However, for some there is a sufficient body of evidence to suggest that some AEDs used in certain epilepsies may consistently cause worsening of seizures. Seizure aggravation may include increase in the frequency or severity of existing seizures, emergence of new types of seizure, or the occurrence of status epilepticus. The pathophysiology of seizure aggravation is poorly understood including nonspecific effects such as those associated with sedation, druginduced encephalopathy, and paradoxical or inverse pharmacodynamic effects. For some epilepsies the choice of AEDs may be inappropriate, and although the mechanism of seizure aggravation is not clear, its occurrence may be fairly predictable. This is best documented for the use of carbamazepine in idiopathic generalized and myoclonic epilepsies. Most other AEDs have been reported occasionally to cause seizure aggravation. The lowest risk of seizure aggravation appears to be with valproate. Risk factors for worsening of seizures are epileptic encephalopathy, polytherapy, high frequency of seizures, and cognitive impairment. Advances in pharmacogenomics may in the future enable such adverse effects to be predicted for individual patients. Meanwhile, a systematic approach to reporting AED‐induced seizure aggravation should be developed.
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“Paradoxical excitement is sometimes associated with BZD use and may include exacerbation of seizures in patients with epilepsy (171).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [171]
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Cites
Lamotrigine and Seizure Aggravation in Severe Myoclonic Epilepsy
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Genetic susceptibility to adverse drug reactions
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Suzdak, P. D., & Jansen, J. A. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb02576.x · Cited by 278
Atypical Benign Partial Epilepsy of Childhood
Aicardi, J. F., & Chevrie, J. J. (1982) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1982.tb13620.x · Cited by 251
Exacerbation of Seizures in Children by Carbamazepine
Snead, O. C., & Hosey, L. C. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510103131503 · Cited by 237
Landau‐Kleffner Syndrome: A Pharmacologic Study of Five Cases
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Eldridge, R. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90749-3 · Cited by 180
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Flagged first, then by citations
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Items 101–111 of 111
Guidelines for pharmacological treatment of epilepsy
Bašić, S., Gadže, Ž. P., Prpić, I., Poljaković, Z., Malenica, M., Juraški, R. G., Marković, I., Sporiš, I. Š., Jurić, J. Š., Sporiš, D., et al. (2021) · Liječnički vjesnik · doi:10.26800/lv-143-11-12-4
(2010) · Wiley eBooks · doi:10.1002/9781444325201.furread
Anticonvulsant Agents: Pharmacology and Biochemistry
Löscher, W. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_466-2
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Focal Onset Seizures: New Treatment Options in The Clinical Practice
Steinhoff, B. J., Carreño, M., & Taylor, J. (2023) · EMJ Neurology · doi:10.33590/emjneurol/10300229
Schiller, K., Avigdor, T., Thomas, J., Daniel Mansilla, D., Abdallah, C., Kortas, A., Unterholzner, G., Pana, R., Rauchenzauner, M., & Frauscher, B. (2025) · Epileptic Disorders · doi:10.1002/epd2.70119
A rare side effect of vagal nerve stimulation: increased seizures and status epilepticus
Kızılkılıç, E. K., Tanrıverdi, T., & Yenı, S. N. (2026) · Acta Neurologica Belgica · doi:10.1007/s13760-026-03009-9
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Kariuki, D. K., Oluka, M. N., Okalebo, F., & Kwasa, J. K. (2026) · Pan African Medical Journal · doi:10.11604/pamj.2026.54.139.44535
Metadata
- Authors
- Gayatri, N., & Livingston, J.
- Affiliations
- Leeds Teaching Hospitals NHS Trust (GB)
- Corresponding author
- Gayatri, NA
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2006-05
- Volume
- 48
- Issue
- 5
- Pages
- 394-398
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W2150292807
- Cited by
- 114
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 4 · 2012: 8
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Keywords
- antiepileptic drugs, adverse drug reactions, carbamazepine, idiopathic generalized epilepsy, myoclonic epilepsy, valproic acid, status epilepticus, paradoxical drug reaction, drug-induced encephalopathy, pharmacogenomics, risk factors, seizure frequency
- MeSH terms
- Anticonvulsants, Child, Epilepsy, Humans, Severity of Illness Index, Prevalence
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