Chromosomal distribution of the major insert in Drosophila melanogaster 28S rRNA genes
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SUMMARY: The major type I insert sequence for the 28S rRNA genes of Drosophila melanogaster has been mapped within the chromosomes using a probe synthesized from a cloned sequence containing the entire 5·4 kb segment. The genomic distribution was shown to be complex in that the insert sequence occurred next to many different types of sequences, in addition to occurring as an insert in the 28S rRNA genes of the X chromosome.In situ hybridization of mitotic chromosomes showed most of the insert units not contained in the ribosomal genes to be located near the ribosomal gene cluster on the X chromosome. Additional sites were detected in polytene chromosomes in region 102C, 8–12 and in the hetero-chromatin of the autosomes.
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R2 elements are present exclusively at the rDNA locus, whereas R1 insertions have also been found in other regions of the genome.
“R2 elements are of particular interest because they are present exclusively at the rDNA locus, whereas R1 insertions have also been found in other regions of the genome (35–38).”
From Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon (2022) · cites this paper as [36]
The Results and Discussion (page not provided) locate type I insert sequences outside rDNA, including on chromosome 4 and in autosomal heterochromatin, supporting the R1 portion. The Introduction describes type II inserts within 28S rRNA genes but does not establish that they occur exclusively at the rDNA locus, so the R2 portion is not supported. (LLM, conf=0.86)
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Research works printed but not linked: 11
- BIRNSTIEL, M. L., SELLS, B. H. & PURDOM, I. F. (1972). Kinetic complexity of RNA molecules Journal of Molecular Biology 63, 21-39.
- BRUTLAQ, D. L., APPELS, R., DENNIS, E. S. & PEACOCK, W. J. (1977). Highly repeated DNA in Drosophila melanogaster. Journal of Molecular Biology, 112, 31-47.
- DAWTD, I. B. & BOTCHAN, P. (1977). Sequences homologous to ribosomal insertions occur in the Drosophila genome outside the nucleolus organizer. Proceedings of the National Academy of Science (Wash.) 74, 4233-4237.
- DAWID, I. B. & WELLATTER, P. K. (1978). Ribosomal DNA and related sequences in Droso- phila melanogaster. Cold Spring Harbor Symposium of Quantitative Biology. 42, 1185-1194.
- GLOVER, D. M. (1977). Cloned segment of Drosophila melanogaster rDNA containing new types of sequence insertion. Proceedings of the National Academy of Science (Wash.) 74, 4932-4936.
- GLOVER, D. M., KIDD, S. J., ROIHA, H. T., JORDAN, B. R., ENDOW, S. & APPELS, R. (1978). Interrupter sequences that are widely distributed in the Drosophila genome. Biochemical Society Transactions 6, 732-736.
- HOCHMAN, B. (1976). The fourth chromosome of Drosophila melanogaster. In Genetics and Biology of Drosophila, vol. 1 b (ed. M. Ashburner and E. Novitski), pp. 903-928. New York: Academic Press.
- PEACOCK, W. J., BRUTLAG, D., GOLDRING, E., APPELS, R., HINTON, C. W. & LINDSLEY, D. L. (1973). The organization of highly repeated DNA sequences in Drosophila 'melano- gaster chromosomes. Cold Spring Harbor Symposium of Quantitative Biology 38, 405-416.
- PEACOCK, W. J., LOHE, A., GERLACH, W. L., DUNSMTJIB, P., DENNIS, E. S. & APPELS, R. (1978). Fine structure and evolution of DNA in heterochromatin. Cold Spring Harbor Symposium of Quantative Biology 42, 1121-1135.
- RUDKIN, G. T. (1972). Replication in polytene chromosomes. In Results and Problems in Cell Differentiation, vol. 4 (ed. W. Beermann), pp. 59-85. New York: Springer-Verlag.
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Kidd, S. J., & Glover, D. M. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90428-9 · Cited by 79 · see citing works
Self-citationFefelova, E. A., Pleshakova, I. M., Mikhaleva, E. A., Pirogov, S. A., Poltorachenko, V. A., Abramov, Y. A., Romashin, D. D., Shatskikh, A. S., Blokh, R. S., Gvozdev, V. A., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1276 · Cited by 15 · see citing works
- Authors
- Peacock, W. J., Appels, R., Endow, S., & Glover, D.
- Affiliations
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Duke University (US)
- Imperial College London (GB)
- Venue
- Genetical Research
- Publisher
- Hindawi Limited
- Published
- 1981-04
- Volume
- 37
- Issue
- 2
- Pages
- 209-214
- ISSN
- 0016-6723 (ISSN-L)
- 1469-5073
- OpenAlex
- W2047745064
- Cited by
- 50
- References
- 0
- Citations by year
- 2025: 2 · 2021: 1 · 2018: 1 · 2017: 1 · 2013: 1
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genetics Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- 28S rRNA gene, Drosophila melanogaster, X chromosome, chromosome distribution, in situ hybridization, polytene chromosomes, heterochromatin, ribosomal DNA
- MeSH terms
- Animals, Chromosome Mapping, DNA Transposable Elements, Drosophila melanogaster, Female, Genes, RNA, Ribosomal, X Chromosome
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