A hitch-hiking guide to the genome: a commentary on 'The hitch-hiking effect of a favourable gene' by John Maynard Smith and John Haigh
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Natural or artificial selection targets the genome in response to environmental pressures or stresses as shaping adaptation and evolution.
“The rationale is that natural or artificial selection targets the genome in response to environmental pressures or stresses as shaping adaptation and evolution.”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Charlesworth, 2007
The main text (page not supplied) describes favourable mutations spreading through populations and changing genomic variability. It also gives malaria protection as an example and links hitchhiking to adaptation in bacterial genomes. It does not address artificial selection or establish the broader claim about environmental pressures or stresses generally. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIf a new allele of a mutation is beneficial under certain environmental pressure or stress, then the frequency of these alleles will rapidly increase in the population.
“This implies that if the new allele of a mutation is beneficial (increases the fitness of their carriers) under certain environmental pressure or stress, then the frequency of these alleles will rapidly increase in the population (Charlesworth, 2007).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Charlesworth, 2007
In the main text (page unavailable), Charlesworth describes a favourable mutation spreading through a population and potentially reaching fixation. The paper does not establish that its frequency will increase rapidly under environmental pressure or stress; it also discusses favourable mutations that remain segregating rather than reaching fixation. (LLM, conf=0.83)
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References 22 · Cited by 19
Research works printed but not linked: 7
- Atwood, K. C., Schneider, L. K. & Ryan, F. J. (1951). Periodic selection in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 37, 146-155.
- Barton, N. H. (2000). Genetic hitchhiking. Philosophical Transactions of the Royal Society, Series B 355, 1553-1562.
- Eanes, W. F. (1999). Analysis of selection on enzyme poly- morphisms. Annual Review of Ecology and Systematics 30, 301-326.
- Kan, Y. W. & Dozy, A. M. (1978). Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relation to sickle mutation. Proceedings of the National Academy of Sciences of the USA 75, 5631-5635.
- Kwiatkowski, D. P. (2005). How malaria has affected the human genome and what human genetics can teach us about malaria.. American Journal of Human Genetics 77, 171-192.
- Lewontin, R. C. (1974). The Genetic Basis of Evolutionary Change. New York: Columbia University Press.
- Nielsen, R. (2005). Molecular signatures of natural selec- tion. Annual Review of Genetics 39, 197-218.
- Authors
- CHARLESWORTH, B.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- CHARLESWORTH, BRIAN
- ORCID
- CHARLESWORTH, BRIAN
- Venue
- Genetics Research
- Publisher
- Hindawi Limited
- Published
- 2007-12
- Volume
- 89
- Issue
- 5-6
- Pages
- 389-390
- ISSN
- 0016-6723 (ISSN-L)
- 1469-5073
- OpenAlex
- W2106993546
- Cited by
- 19
- References
- 22
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 4 · 2012: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genetics Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- genetic hitchhiking, genetic drift, population genetics, recombination
- MeSH terms
- Animals, Humans, Isoenzymes, Selection, Genetic, Genetic Variation, Genome
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