Microorganisms and their relation to fever
Abstract
It appears to be widely believed that the fever of infective disease is due to absorption of phyrogenetic substances liberated from dead microorganisms by a combuined process of lysis and extraction in the body of the infected subject. The diffusion of products of the action of bacterial autolytic enzymes on microorganisms after their destruction by the defensive agencies of the body is a variant on the same theme. Closely allied are the theories of protein fever, and of anaphylactic fever, in so far as they relate to the supposed possession by microorganisms, or their split products, of pyrogenetic properties. The absorption of alien protein, or of derivatives of alien protoplasm, from organisms that are dead, is, in short, the essential feature of this conception of fever production.
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Reagents like Limulus Amebocyte Lysate (LAL), Tachypleus Amebocyte Lysate (TAL) and the Rabbit Pyrogen Test (RPT) are used in laboratories worldwide to detect pyrogenic contaminations.
“Nonetheless, reagents like Limulus Amebocyte Lysate (LAL), Tachypleus Amebocyte Lysate (TAL) as well as the Rabbit Pyrogen Test (RPT), an in vivo method which was already developed in 1912 [56], are used in laboratories worldwide to detect pyrogenic contaminations.”
From A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation (2022) · cites this paper as [56]
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Research works printed but not linked: 3
- HORT, E. C. and PENFOLD, W. J. (1911). The Dangers of Saline Injections. British Medical Journal, 1911, n. 1510. The Relation of Salvarsan Fever to other forms of infectious Fever. Proc. of Roy. Soc. ofMed., 1912, v. 1911 et seq. A critical study of experimental Fever. Proc. of Roy. Soc. B, LXXXV. 1912.
- VAUGHAN WHEELER GIDLEY (1909). Protein Fever. Journal of the American Medical Association.
- HORT, E. C. Autotoxaemia and Infection. Proc. Roy. Soc, 1910, LXXXII. 529-545.
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A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation
Cassotta, M., Bartnicka, J. J., Pistollato, F., Parvatam, S., Weber, T., D'Alessandro, V., Bastos, L. F., & Coecke, S. (2022) · Engineering in Life Sciences · doi:10.1002/elsc.202100167 · Cited by 33 · see citing works
- Authors
- Hort, E. C., & Penfold, W. J.
- Venue
- Journal of Hygiene
- Publisher
- Cambridge University Press (CUP)
- Published
- 1912-10
- Volume
- 12
- Issue
- 3
- Pages
- 361-390
- ISSN
- 0022-1724
- Cited by
- 38
- References
- 0
- Language
- en
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