Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy
Abstract
BACKGROUND: The paper describes a randomized controlled trial of targeting cognitive behavioural therapy (CBT) during prodromal or early signs of relapse in schizophrenia. We hypothesized that CBT would result in reduced admission and relapse, reduced positive and negative symptoms, and improved social functioning. METHOD: A total of 144 participants with schizophrenia or a related disorder were randomized to receive either treatment as usual (TAU) (N = 72) or CBT+TAU (N = 72). Participants were prospectively followed up between entry and 12 months. RESULTS: At 12 months, 11 (15.3%) participants in the CBT group were admitted to hospital compared to 19 (26.4%) of the TAU group (hazard ratio = 0.53, P = 0.10, 95% CI 0.25, 1.10). A total of 13 (18.1%) participants in CBT relapsed compared to 25 (34.7%) in TAU (hazard ratio = 0.47, P < 0O05, 95% CI 0.24, 0.92). In addition, the CBT group showed significantly greater improvement in positive symptoms, negative symptoms, global psychopathology, performance of independent functions and prosocial activities. CONCLUSIONS: The study provides evidence for the feasibility and effectiveness for targeting CBT on the appearance of early signs of relapse in schizophrenia. The results are discussed in context of the study's methodological limitations.
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Use of good emotion regulation strategies leads to a reduction in the relapse rate.
“and a reduction in the relapse rate (35).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [35]
The Discussion (p. 9) reports a lower 12-month relapse rate with targeted CBT than with usual treatment (18.1% versus 34.7%). The treatment included coping strategies and work to reduce fear and helplessness (Cognitive behavioural therapy, p. 5), but the trial did not isolate emotion-regulation strategies as the cause of the reduction. (LLM, conf=0.86)
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References 63 · Cited by 229
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- Authors
- GUMLEY, A., O'GRADY, M., MCNAY, L., REILLY, J., POWER, K., & NORRIE, J.
- Affiliations
- University of Stirling (GB)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-04
- Volume
- 33
- Issue
- 3
- Pages
- 419-431
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2120352439
- Cited by
- 229
- References
- 63
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 11 · 2018: 11 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 15 · 2013: 13 · 2012: 14
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
- Keywords
- schizophrenia, cognitive behavioral therapy, early intervention, relapse prevention, prodromal symptoms, hospitalization, positive symptoms, negative symptoms, social functioning, usual care
- MeSH terms
- Crisis Intervention, Female, Humans, Male, Recurrence, Schizophrenia, Schizophrenic Psychology, Time Factors, Cognitive Behavioral Therapy, Treatment Outcome
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