Vulnerability to depression: what is the role of stress genes in gene × environment interaction?
Open accessAbstract
Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic–pituitary–adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307–313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene×environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.
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One proposed mechanism of early life stress interactions with serotonergic genes such as 5-HTTLPR involves modulation of stress responses through HPA axis activity.
“One proposed mechanism of ELS interactions with serotonergic genes such as 5-HTTLPR involves modulation of stress responses through HPA axis activity (El Hage et al. 2009).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as El Hage et al. 2009
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Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
Nugent, N. R., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2151-x · Cited by 269 · see citing works
“Moreover, there is strong evidence from human and animal studies that the stress response is modulated in part by serotonergic neurotransmission (for reviews, see El Hage et al. 2009; Holmes 2008).”
BackgroundMechanisms of antidepressant resistance
El-Hage, W., Leman, S., Camus, V., & Belzung, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00146 · Cited by 111 · see citing works
Self-citationShao, J., Wei, Y., & Wei, X. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111540 · Cited by 58 · see citing works
Yrondi, A., Aouizerate, B., Bennabi, D., Richieri, R., D'Amato, T., Bellivier, F., Bougerol, T., Horn, M., Camus, V., Courtet, P., et al. (2020) · Depression and Anxiety · doi:10.1002/da.22997 · Cited by 37 · see citing works
Self-citation
- Authors
- El Hage, W., Powell, J. F., & Surguladze, S. A.
- Affiliations
- King's College London (GB)
- ORCID
- Powell, J. F.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-02-12
- Volume
- 39
- Issue
- 9
- Pages
- 1407-1411
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2116991563
- Cited by
- 59
- References
- 2
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 11
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Servier
- H. Lundbeck A/S
- Cilag
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- depression vulnerability, gene-environment interaction, stress response genes, serotonergic genes, hypothalamic-pituitary-adrenal axis, stress response, genetic susceptibility, life events, depressive disorders
- MeSH terms
- Alleles, Amygdala, Arousal, Major Depressive Disorder, Epistasis, Genetic, Gene Expression Regulation, Gyrus Cinguli, Humans, Hypothalamo-Hypophyseal System, Life Change Events, Phenotype, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Glucocorticoid, Social Environment, Receptors, Mineralocorticoid, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins
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