Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls
Abstract
Background We conducted a meta-analysis of voxel-based morphometry (VBM) studies in autism spectrum disorder (ASD) to clarify the changes in regional white-matter volume underpinning this condition, and generated an online database to facilitate replication and further analyses by other researchers. Method PubMed, ScienceDirect, Web of Knowledge and Scopus databases were searched between 2002 (the date of the first white-matter VBM study in ASD) and 2010. Manual searches were also conducted. Authors were contacted to obtain additional data. Coordinates were extracted from clusters of significant white-matter difference between patients and controls. A new template for white matter was created for the signed differential mapping (SDM) meta-analytic method. A diffusion tensor imaging (DTI)-derived atlas was used to optimally localize the changes in white-matter volume. Results Thirteen datasets comprising 246 patients with ASD and 237 healthy controls met inclusion criteria. No between-group differences were found in global white-matter volumes. ASD patients showed increases of white-matter volume in the right arcuate fasciculus and also in the left inferior fronto-occipital and uncinate fasciculi. These findings remained unchanged in quartile and jackknife sensitivity analyses and also in subgroup analyses (pediatric versus adult samples). Conclusions Patients with ASD display increases of white-matter volume in tracts known to be important for language and social cognition. W…
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Peak-based meta-analyses are based on coordinates from published studies rather than raw statistical brain maps.
“Peak-based meta-analyses are based on coordinates from published studies rather than raw statistical brain maps (42).”
From Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis (2014) · cites this paper as [42]
Voxel-wise meta-analytical methods provide excellent control for false-positive results, but false-negative results are more difficult to avoid.
“Third, while voxel-wise meta-analytical methods provide excellent control for false-positive results, false-negative results are more difficult to avoid (42).”
From Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis (2014) · cites this paper as [42]
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- Authors
- Radua, J., Via, E., Catani, M., & Mataix-Cols, D.
- Affiliations
- King's College London (GB)
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-11-16
- Volume
- 41
- Issue
- 7
- Pages
- 1539-1550
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2065827336
- Cited by
- 183
- References
- 96
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 10 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 16 · 2014: 18 · 2013: 25 · 2012: 15
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- autism spectrum disorder, white matter volume, voxel-based morphometry, arcuate fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, white matter atlas, diffusion tensor imaging, language and social cognition, neuroanatomical differences
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Female, Humans, Image Processing, Computer-Assisted, Male, Myelin Sheath, Diffusion Magnetic Resonance Imaging, Young Adult
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