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Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity
Abstract
The purpose of this review is to examine the various effects of low- molecular-weight electrolytes on the associations and interactions of proteins and nucleic acids. Our primary interest is in general electrostatic effects, rather than chemical effects (specific interactions) of particular ions (e.g. transition metals, protons). We consider those interactions in which a variation in salt concentration has a significant effect on the macromolecular equilibrium, and analyse the effects of salt in these situations in terms of (i) direct participation of ions in the biopolymer reaction, (ii) Debye—Hückel screening by salt ions of the charge interactions on the biopolymers, and (iii) the reduction in water activity brought about at high salt concentrations.
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Citations
Cited by
Chaires, J. B., Dattagupta, N., & Crothers, D. M. (1982) · Biochemistry · doi:10.1021/bi00260a005 · Cited by 938
Extreme disorder in an ultrahigh-affinity protein complex
Borgia, A., Borgia, M. B., Bugge, K., Kissling, V. M., Heidarsson, P. O., Fernandes, C. B., Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., et al. (2018) · Nature · doi:10.1038/nature25762 · Cited by 653
Characterization of the cytoplasm of Escherichia coli K-12 as a function of external osmolarity
Cayley, S., Lewis, B. A., Guttman, H. J., & Record, M. T. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90212-o · Cited by 486
Self-citationEvidence of a charge-density threshold for optimum efficiency of biocidal cationic surfaces
Kügler, R., Bouloussa, O., & Rondelez, F. (2005) · Microbiology · doi:10.1099/mic.0.27526-0 · Cited by 438
Role of the hydrophobic effect in stability of site-specific protein-DNA complexes
Ha, J.-H., Spolar, R. S., & Record, M. T. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90608-6 · Cited by 386
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Metadata
- Authors
- Record, M. T., Anderson, C. F., & Lohman, T. M.
- Venue
- Quarterly Reviews of Biophysics
- Publisher
- Cambridge University Press (CUP)
- Published
- 1978-05
- Volume
- 11
- Issue
- 2
- Pages
- 103-178
- ISSN
- 0033-5835 (ISSN-L)
- 1469-8994
- OpenAlex
- W2026884660
- Cited by
- 1,673
- References
- 0
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity. https://app.cochat.ai/papers/10.1017/s003358350000202x
- The paper
- Record, M. T., Anderson, C. F., & Lohman, T. M. (1978). Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity. Quarterly Reviews of Biophysics. https://doi.org/10.1017/s003358350000202x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
