Cited by 1,125Pain Mechanisms and TreatmentsSex and Gender in HealthcarePain Management and Placebo Effect

The DOI matches its Crossref record.

Sex differences in pain

Berkley, Karen J.·1997·Behavioral and Brain Sciences

Open this paper in CoChat — free account

Abstract

Are there sex differences in pain? For experimentally delivered somatic stimuli, females have lower thresholds, greater ability to discriminate, higher pain ratings, and less tolerance of noxious stimuli than males. These differences, however, are small, exist only for certain forms of stimulation and are affected by many situational variables such as presence of disease, experimental setting, and even nutritive status. For endogenous pains, women report more multiple pains in more body regions than men. With no obvious underlying rationale, some painful diseases are more prevalent among females, others among males and, for many diseases, symptoms differ between females and males. Sex differences in attitudes exist that affect not only reporting, coping, and responses to treatment, but also measurement and treatment. So many variables are operative, however, that the most striking feature of sex differences in reported pain experience is the apparent overall lack of them. On the other hand, deduction from known biological sex differences suggests that these are powerful sex differences in the operation of pain mechanisms. First, the vaginal canal provides an additional route in women for internal trauma and invasion by pathological agents that puts them at greater risk for developing hyperalgesia in multiple body regions. Second, sex differences in temporal patterns are likely to give rise to sex differences in how pain is "learned" and stimuli are interpreted, a situation that could lead to a greater variability and wider range of pains without obvious peripheral pathology among females. Third, sex differences in the actions of sex hormones suggest pain-relevant differences in the operation of many neuroactive agents, opiate and nonopiate systems, nerve growth factor, and the sympathetic system. Thus, while inductive analysis of existing data demonstrate more similarities than differences in pain experience between females and males, deductive analysis suggests important operational sex differences in its production.

Integrity signals

Registry

Crossref · 10.1017/s0140525x97221485

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 501–600 of 998

The effect on mechanical pain threshold over human muscles by oral administration of granisetron and diclofenac-sodium
Christidis, N., Kopp, S., & Ernberg, M. M. (2004) · Pain · doi:10.1016/j.pain.2004.10.016 · Cited by 33
Sex differences in the effects of amiloride on formalin test nociception in mice
Chanda, M. L., & Mogil, J. S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00902.2005 · Cited by 33
The Face of Pain ‐ A Pilot Study to Validate the Measurement of Facial Pain Expression with an Improved EMG Method
Wolf, K., Raedler, T. J., Henke, K. B., Kiefer, F., Maß, R., Quante, M., & Wiedemann, K. (2005) · Pain Research and Management · doi:10.1155/2005/643075 · Cited by 33
Adverse Drug Reactions to Opioids: A Study in a National Pharmacovigilance Database
Gustafsson, M., Matos, C., Joaquim, J. J., Scholl, J. H. G., & van Hunsel, F. P. A. M. (2023) · Drug Safety · doi:10.1007/s40264-023-01351-y · Cited by 34
Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats
Peng, H., Chen, G., Tung, K., Chien, Y.-W., Lai, C., Hsieh, M., Chiu, C.-H., Lai, C., Lee, S., & Lin, T.-B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00129.2009 · Cited by 32
Sex Differences and Estrous Cycle Effects of Peripheral Serotonin-Evoked Rodent Pain Behaviors
Kaur, S., Benton, W. L., Tongkhuya, S. A., Lopez, C. M. C., Uphouse, L. L., & Averitt, D. L. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.017 · Cited by 33
Safety footwear: A survey of end-users
Janson, D. J., Newman, S. T., & Dhokia, V. G. (2020) · Applied Ergonomics · doi:10.1016/j.apergo.2020.103333 · Cited by 32
Is Drug Utilization in Greece Sex dependent? A Population‐based Study
Athanasopoulos, C., Pitychoutis, P. M., Messari, I., Lionis, C. D., & Papadopoulou‐Daifoti, Z. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2012.00920.x · Cited by 32
Sex Differences in Pain
Keogh, E. (2008) · Reviews in Pain · doi:10.1177/204946370800200203 · Cited by 36
Gender‐related differences in visceral perception in health and irritable bowel syndrome
Kim, H. S., Rhee, P., Park, J., Lee, J. H., Kim, Y., Kim, J. J., & Rhee, P. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.04060.x · Cited by 32
Sex differences in pain-induced effects on the septo-hippocampal system
Aloisi, A. M. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00030-1 · Cited by 32
Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments
Barrett, J. E., Shekarabi, A., & Inan, S. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000506 · Cited by 35
Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations
Schuttert, I., Wolff, A. P., Preuper, R. H. R. S., Malmberg, A. G., Reneman, M. F., & Timmerman, H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144849 · Cited by 34
Sex-related differences in prepulse inhibition of startle in irritable bowel syndrome (IBS)
Kilpatrick, L. A., Ornitz, E. M., Ibrahimovic, H., Treanor, M., Craske, M. G., Nazarian, M., Labus, J. S., Mayer, E. A., & Naliboff, B. D. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.02.012 · Cited by 31
Repetitive noxious neonatal stimuli increases dentate gyrus cell proliferation and hippocampal brain‐derived neurotrophic factor levels
Malheiros, J. M., Lima, M. M. S., Avanzi, R. D. T., da Silva, S. G., Suchecki, D., Guinsburg, R., & Covolan, L. (2013) · Hippocampus · doi:10.1002/hipo.22235 · Cited by 30
Is it All about Sex? Acupuncture for the Treatment of Pain from a Biological and Gender Perspective
Lund, I., & Lundeberg, T. (2008) · Acupuncture in Medicine · doi:10.1136/aim.26.1.33 · Cited by 33
Increasing Optimism Protects Against Pain-Induced Impairment in Task-Shifting Performance
Boselie, J. J. L. M., Vancleef, L. M. G., & Peters, M. L. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.12.007 · Cited by 34
Does sedentary behavior increase the risk of low back pain? A population-based co-twin study of Spanish twins
Amorim, A. B., Levy, G. M., Pérez‐Riquelme, F., Simić, M., Pappas, E., Dario, A. B., Ferreira, M. L., Carrillo, E., Luque-Suárez, A., Ordoñana, J. R., et al. (2017) · The Spine Journal · doi:10.1016/j.spinee.2017.02.004 · Cited by 30
The painful truth: work-related musculoskeletal disorders in Australian surgeons
Grant, K. M. K., Vo, T., & Tiong, L. U. (2019) · Occupational Medicine · doi:10.1093/occmed/kqz155 · Cited by 31
Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats
Green‐Fulgham, S. M., Ball, J. B., Kwilasz, A. J., Harland, M. E., Frank, M. G., Dragavon, J. M., Grace, P. M., & Watkins, L. R. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.004 · Cited by 32
Heart rate variability is associated with thermal heat pain threshold in males, but not females
Tracy, L. M., Koenig, J., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.017 · Cited by 30
Sexually Dimorphic Immune and Neuroimmune Changes Following Peripheral Nerve Injury in Mice: Novel Insights for Gender Medicine
Vacca, V., Marinelli, S., Angelis, F. D., Angelini, D. F., Piras, E., Battistini, L., Pavone, F., & Coccurello, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094397 · Cited by 31
Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats.
Mert, T., & Güneş, Y. (2012) · Europe PMC (PubMed Central) · Cited by 30
Electroacupuncture Suppresses Mechanical Allodynia and Nuclear Factor Kappa B Signaling in Streptozotocin‐Induced Diabetic Rats
Shi, L., Zhang, H., Xiao, Y., Hu, J., & Xu, G. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12035 · Cited by 30
Fear of Severe Pain Mediates Sex Differences in Pain Sensitivity Responses to Thermal Stimuli
Horn, M. E., Alappattu, M. J., Gay, C. W., & Bishop, M. D. (2014) · Pain Research and Treatment · doi:10.1155/2014/897953 · Cited by 30
Does high blood pressure reduce the risk of chronic low back pain? The Nord‐Trøndelag Health Study
Heuch, I., Heuch, I., Hagen, K., & Zwart, J. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00398.x · Cited by 31
No pain, no social gains: A social-signaling perspective of human pain behaviors
Vigil, J. M. (2014) · World Journal of Anesthesiology · doi:10.5313/wja.v3.i1.18 · Cited by 30
Chronic pain in children and adolescents
Eccleston, C., Bruce, E., & Carter, B. (2006) · Nursing Children and Young People · doi:10.7748/paed.18.10.30.s21 · Cited by 30
Muscle pain in myophosphorylase deficiency (McArdle’s disease): The role of gender, genotype, and pain-related coping
Rommel, O., Kley, R. A., Dekomien, G., Epplen, J. T., Vorgerd, M., & Hasenbring, M. I. (2006) · Pain · doi:10.1016/j.pain.2006.04.017 · Cited by 29
Women and Pain
Miaskowski, C. A. (1997) · Critical Care Nursing Clinics of North America · doi:10.1016/s0899-5885(18)30238-7 · Cited by 32
Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism
Small, K. M., Nag, S., & Mokha, S. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.034 · Cited by 29
The influence of reward sensitivity, heart rate dynamics and EEG-delta activity on placebo analgesia
Pascalis, V. D., & Scacchia, P. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.014 · Cited by 29
Value of Different Diagnostic Criteria for the Irritable Bowel Syndrome Among Men and Women
Hammer, J., & Talley, N. J. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181574d48 · Cited by 29
Variation of pain and vasomotor responses evoked by intramuscular infusion of hypertonic saline in human subjects: Influence of gender and its potential neural mechanisms
Lei, J., & You, H. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.003 · Cited by 29
Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats
Шекунова, Е. В., & Bespalov, A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.012 · Cited by 29
A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain
Lötsch, J., & Ultsch, A. (2013) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2013.07.010 · Cited by 29
Gender Differences in Coping with Tension-Type Headaches
Rollnik, J. D., Karst, M., Piepenbrock, S., Gehrke, A., Dengler, R., & Fink, M. (2003) · European Neurology · doi:10.1159/000072502 · Cited by 29
The biosocial female choice theory of social stratification*
Ellis, L. (2001) · Biodemography and Social Biology · doi:10.1080/19485565.2001.9989040 · Cited by 29
Comments on “The Feldenkrais Method®: A Dynamic Approach to Changing Motor Behavior”
Ives, J. C. (2003) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2003.10609072 · Cited by 31
The effects of a cold-water stimulus on butorphanol effects in males and females
Zacny, J. P., & Beckman, N. J. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.01.021 · Cited by 29
Estrogen attenuates antinociception produced by stimulation of Kölliker–Fuse nucleus in the rat
Nag, S., & Mokha, S. S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03775.x · Cited by 29
Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus
Reddy, H., Arendt‐Nielsen, L., Staahl, C., Pedersen, J., Funch-Jensen, P. M., Gregersen, H. N., & Drewes, A. M. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-3006-x · Cited by 29
The capsaicin analogue SDZ249-665 attenuates the hyper-reflexia and referred hyperalgesia associated with inflammation of the rat urinary bladder
Jaggar, S., Scott, H. C. F., James, I. F., & Rice, A. S. C. (2001) · Pain · doi:10.1016/s0304-3959(00)00366-3 · Cited by 29
Effects of Formalin Pain on Hippocampal c-Fos Expression in Male and Female Rats
Ceccarelli, I., Scaramuzzino, A., & Aloisi, A. M. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00145-8 · Cited by 29
Single-Point but Not Tonic Cuff Pressure Pain Sensitivity Is Associated with Level of Physical Fitness – A Study of Non-Athletic Healthy Subjects
Lemming, D., Börsbo, B., Sjörs, A., Lind, E.-B., Arendt‐Nielsen, L., Graven‐Nielsen, T., & Gerdle, B. U. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125432 · Cited by 28
The Canadian STOP-PAIN Project
Racine, M., Dion, D., Dupuis, G., Guerriere, D. N., Zagorski, B., Choinière, M., Banner, R., Barton, P. M., Boulanger, A., Clark, A. J., et al. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182a0de5e · Cited by 28
Sex‐differences in network level brain dynamics associated with pain sensitivity and pain interference
Kim, J. A., Bosma, R. L., Hemington, K. S., Rogachov, A., Osborne, N. R., Cheng, J. C., Dunkley, B. T., & Davis, K. D. (2020) · Human Brain Mapping · doi:10.1002/hbm.25245 · Cited by 33
The Effect of Sex on the Minimum Local Analgesic Concentration of Ropivacaine for Caudal Anesthesia in Anorectal Surgery
Li, Y., Zhou, Y., Chen, H., et al. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181d6bade · Cited by 28
Sex differences in hypothalamic–pituitary–adrenal axis function in patients with chronic pain syndrome
Turner‐Cobb, J. M., Osborn, M., da Silva, L., Keogh, E., & Jessop, D. S. (2010) · Stress · doi:10.3109/10253890903524785 · Cited by 27
Gynecologic management of neuropathic pain
Tu, F. F., Hellman, K. M., & Bačkonja, M. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.05.011 · Cited by 28
Increased Cutaneous Nerve Fibers in Female Specimens
Mowlavi, A., Cooney, D. S., Febus, L., et al. (2005) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000182339.83156.06 · Cited by 28
Predictors of abdominal pain in schoolchildren: a 4-year population-based prospective study
El‐Metwally, A., Halder, S. L. S., Thompson, D., Macfarlane, G. J., & Jones, G. T. (2007) · Archives of Disease in Childhood · doi:10.1136/adc.2006.115089 · Cited by 28
Pain intensity during the first 7 days following the application of light and heavy continuous forces
Ogura, M., Kamimura, H., Al-Kalaly, A., Nagayama, K., Taira, K., Nagata, J., & Miyawaki, S. (2008) · European Journal of Orthodontics · doi:10.1093/ejo/cjn072 · Cited by 28
Training-Induced Functional Gains following SCI
Ward, P. J., Herrity, A. N., Harkema, S. J., et al. (2016) · Neural Plasticity · doi:10.1155/2016/4307694 · Cited by 28
The relationship between chronic facial pain and a history of trauma and surgery
Plesh, O., Gansky, S. A., Curtis, D. A., & Pogrel, M. A. (1999) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/s1079-2104(99)70187-3 · Cited by 27
Aspects of Pain, Its Assessment and Evaluation from An Acupuncture Perspective
Lund, I., & Lundeberg, T. (2006) · Acupuncture in Medicine · doi:10.1136/aim.24.3.109 · Cited by 28
Differences Between Male and Female Responses to Painful Thermal and Mechanical Stimulation of the Human Esophagus
Pedersen, J., Reddy, H., Funch-Jensen, P. M., Arendt‐Nielsen, L., Gregersen, H. N., & Drewes, A. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000037789.25734.06 · Cited by 27
Trigeminal nerve injury‐induced thrombospondin‐4 up‐regulation contributes to orofacial neuropathic pain states in a rat model
Li, K.-W., Kim, D., Zaucke, F., & Luo, Z. D. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00396.x · Cited by 27
Immediate Effects of Spinal Manipulative Therapy on Regional Antinociceptive Effects in Myofascial Tissues in Healthy Young Adults
Srbely, J. Z., Vernon, H. T., Lee, D. K., et al. (2013) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2013.01.005 · Cited by 27
Visceral sensory neurons that innervate both uterus and colon express nociceptive TRPv1 and P2X3 receptors in rats.
Chaban, V. V. (2008) · PubMed · Cited by 27
Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: Implications for sex specific pain modulation
LaCroix‐Fralish, M. L., Tawfik, V. L., Nutile‐McMenemy, N., & DeLeo, J. A. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.03.010 · Cited by 28
Gonadectomy and persistent pain differently affect hippocampal c-Fos expression in male and female rats
Aloisi, A. M., Ceccarelli, I., & Herdegen, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00819-3 · Cited by 27
The influence of sex on neuroimmune communication, pain, and physiology
Alexander, S. N., Green, A. R., Debner, E. K., Freitas, L. E. R., Abdelhadi, H. M. K., Szabo-Pardi, T. A., & Burton, M. D. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00660-w · Cited by 30
Timing and duration of anti–α4β1 integrin treatment after spinal cord injury: effect on therapeutic efficacy
Fleming, J. C., Bao, F., Chen, Y., Hamilton, E. F., González-Lara, L. E., Foster, P. J., & Weaver, L. C. (2009) · Journal of Neurosurgery Spine · doi:10.3171/2009.6.spine08915 · Cited by 26
The Effects of Acceptance of Thoughts, Mindful Awareness of Breathing, and Spontaneous Coping on an Experimentally Induced Pain Task
Forsyth, L., & Hayes, L. L. (2014) · The Psychological Record · doi:10.1007/s40732-014-0010-6 · Cited by 30
Predictive Factors for Pain After Endoscopic Resection of Gastric Tumors
Kim, S. Y., Jung, S. W., Choe, J. W., et al. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4325-9 · Cited by 26
Pain and Temporomandibular Disorders
Shaefer, J. R., Holland, N. D., Whelan, J., & Velly, A. M. (2013) · Dental Clinics of North America · doi:10.1016/j.cden.2013.02.005 · Cited by 26
Calcium channel blockers reduce oxaliplatin-induced acute neuropathy: A retrospective study of 69 male patients receiving modified FOLFOX6 therapy
Tatsushima, Y., Egashira, N., Narishige, Y., et al. (2012) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2012.10.006 · Cited by 26
Endogenous Inhibition of the Nociceptive Flexion Reflex (NFR) and Pain Ratings During the Menstrual Cycle in Healthy Women
Bartley, E. J., & Rhudy, J. L. (2012) · Annals of Behavioral Medicine · doi:10.1007/s12160-012-9345-x · Cited by 26
Sex-Related Differences in GI Disorders
Prusator, D. K., & Chang, L. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_121 · Cited by 26
Cholecystokinin-8-like immunoreactivity is sexually dimorphic in a midline population of rat lumbar neurons
Phan, D. C., & Newton, B. W. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00819-8 · Cited by 26
Activation of the trigeminal α 2 -adrenoceptor produces sex-specific, estrogen dependent thermal antinociception and antihyperalgesia using an operant pain assay in the rat
Nag, S., & Mokha, S. S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.012 · Cited by 26
Variations in Perceived Pain Associated with Emotional Distress and Social Identity in AIDS
Rotheram‐Borus, M. J. (2000) · AIDS Patient Care and STDs · doi:10.1089/10872910050206586 · Cited by 26
Differential modulation of TMJ neurons in superficial laminae of trigeminal subnucleus caudalis/upper cervical cord junction region of male and cycling female rats by morphine
Okamoto, K., Tashiro, A., Hirata, H., & Bereiter, D. A. (2005) · Pain · doi:10.1016/j.pain.2004.12.013 · Cited by 26
Anesthetic efficacy and pain induced by dental anesthesia: the influence of gender and menstrual cycle
Tófoli, G. R., Ramacciato, J. C., Volpato, M. C., Meechan, J. G., Ranali, J., & Groppo, F. C. (2006) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2006.08.024 · Cited by 26
Clinicopathological characteristics of patients with pain after endoscopic submucosal dissection for gastric epithelial neoplasm
Kim, J., Jang, J. Y., Park, Y. M., et al. (2018) · Surgical Endoscopy · doi:10.1007/s00464-018-6345-3 · Cited by 25
Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain
Xie, Z., Feng, J., Cai, T., McCarthy, R., Eschbach, M. D., Wang, Y., Zhao, Y., Yi, Z., Zang, K., Yuan, Y., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.149107 · Cited by 25
Sexual Dimorphism and Temporomandibular Disorders (TMD)
Halpern, L. R., Levine, M., & Dodson, T. B. (2007) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2007.01.012 · Cited by 24
An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury
Bao, F., Chen, Y., Schneider, K. A., & Weaver, L. C. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.09.006 · Cited by 25
Pain-sensorimotor interactions: New perspectives and a new model
Murray, G. M., & Sessle, B. J. (2024) · Neurobiology of Pain · doi:10.1016/j.ynpai.2024.100150 · Cited by 27
Pain Tolerance in Persons With Recognized and Unrecognized Myocardial Infarction: A Population‐Based, Cross‐Sectional Study
Øhrn, A. S. H. M., Nielsen, C. S., Schirmer, H., Stubhaug, A., Wilsgaard, T., & Lindekleiv, H. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003846 · Cited by 24
Sex differences in peripheral immune cell activation: Implications for pain and pain resolution
Friedman, T. N., Caprara, O. L., Zhang, C., Lee, K., May, J. F., Faig, C. A., Baldwin, T. A., Plemel, J. R., Taylor, A. M. W., & Kerr, B. J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.029 · Cited by 25
Silencing the α2 Subunit of γ-aminobutyric Acid Type A Receptors in Rat Dorsal Root Ganglia Reveals Its Major Role in Antinociception Posttraumatic Nerve Injury
Obradović, A. L., Scarpa, J. R., Osuru, H. P., Weaver, J. L., Park, J.-Y., Pathirathna, S., Peterkin, A. L., Lim, Y. H., Jagodic, M. M., Todorovic, S. M., et al. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000767 · Cited by 24
Sex Differences in Psychological Response to Pain in Patients With Fibromyalgia Syndrome
Racine, M., Castarlenas, E., de la Vega, R., Tomé‐Pires, C., Solé, E., Miró, J., Jensen, M. P., Moulin, D. E., & Nielson, W. R. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000132 · Cited by 23
Incidence of nonspecific and radiating low back pain: followup of 24–39‐year‐old adults of the Young Finns Study
Shiri, R., Solovieva, S. A., Husgafvel‐Pursiainen, K., Viikari, J. S. A., Raitakari, O. T., & Viikari-Juntura, E. R. A. (2010) · Arthritis Care & Research · doi:10.1002/acr.20003 · Cited by 24
17β-Estradiol regulates the gene expression of voltage-gated sodium channels: role of estrogen receptor α and estrogen receptor β
Hu, F., Wang, Q., Wang, P., et al. (2011) · Endocrine · doi:10.1007/s12020-011-9573-z · Cited by 24
Neonatal androgen‐dependent sex differences in lumbar spinal cord dopamine concentrations and the number of A 11 diencephalospinal dopamine neurons
Pappas, S. S., Tiernan, C. T., Behrouz, B., Jordan, C. L., Breedlove, S. M., Goudreau, J. L., & Lookingland, K. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22340 · Cited by 26
Reporting of Sex Effects by Systematic Reviews on Interventions for Depression, Diabetes, and Chronic Pain
Duan‐Porter, W., Goldstein, K. M., McDuffie, J. R., Hughes, J. M., Clowse, M. E. B., Klap, R. S., Masilamani, V., LaPointe, N. M. A., Nagi, A., Gierisch, J. M., et al. (2016) · Annals of Internal Medicine · doi:10.7326/m15-2877 · Cited by 24
Evaluation of pain perception during orthodontic debonding of metallic brackets with four different techniques
Kılınç, D. D., & Sayar, G. (2019) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2018-0003 · Cited by 24
Progesterone mediates gonadal hormone differences in tactile and thermal hypersensitivity following L5 nerve root ligation in female rats
LaCroix‐Fralish, M. L., Tawfik, V. L., Nutile‐McMenemy, N., & DeLeo, J. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.048 · Cited by 24
Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice
Zammataro, M., Merlo, S., Barresi, M., Parenti, C., Hu, H., Sortino, M. A., & Chiechio, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00743 · Cited by 28
Low back pain in the Bangladeshi adult population: a cross-sectional national survey
Majumder, M. S. M., Hakim, F., Bandhan, I. H., Razzaque, M. A., Zahid-Al-Quadir, A., Ahmed, S., Choudhury, M. R., Haq, S. A., & Zaman, M. M. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059192 · Cited by 25
No gender-related bias in acute musculoskeletal pain management in the emergency department
Uri, O., Elias, S., Behrbalk, E., & Halpern, P. (2013) · Emergency Medicine Journal · doi:10.1136/emermed-2013-202716 · Cited by 23
Sex moderates the effects of positive and negative affect on clinical pain in patients with knee osteoarthritis
Speed, T. J., Richards, J., Finan, P. H., & Smith, M. T. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.03.005 · Cited by 23
Pain threshold variations in female rats as a function of the estrus cycle.
Ibironke, G. F., & Aji, K. E. (2011) · PubMed · Cited by 23
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects: a machine-learned analysis
Lötsch, J., Geißlinger, G., Heinemann, S., Lerch, F., Oertel, B. G., & Ultsch, A. (2017) · Pain · doi:10.1097/j.pain.0000000000001008 · Cited by 23
Red cloverTrifolium pratense(Linn.) isoflavones extract on the pain threshold of normal and ovariectomized rats – a long‐term study
Vishali, N., Kamakshi, K., Suresh, S., et al. (2010) · Phytotherapy Research · doi:10.1002/ptr.3217 · Cited by 22
PI3K modulates estrogen‐dependent facilitation of colon‐to‐urethra cross‐organ reflex sensitization in ovariectomized female rats
Peng, H., Chen, G., Lai, C., Hsieh, M., Hsu, H., Wu, H., & Lin, T. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06577.x · Cited by 22
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Baptista‐de‐Souza, D., Tavares‐Ferreira, D., Megat, S., Sankaranarayanan, I., Shiers, S. I., Flores, C. M., Ghosh, S., Nunes‐de‐Souza, R. L., Canto‐de‐Souza, A., & Price, T. J. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100049 · Cited by 23
Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats
Temi, S., Rudyk, C., Armstrong, J., Landrigan, J., Dedek, C., Salmaso, N., & Hildebrand, M. E. (2021) · Channels · doi:10.1080/19336950.2020.1871205 · Cited by 22

Authors: Berkley, K. J.
Affiliations: Florida State University (US)
Corresponding author: Berkley, Karen J.
Venue: Behavioral and Brain Sciences
Publisher: Cambridge University Press (CUP)
Published: 1997-09
Volume: 20
Issue: 3
Pages: 371-380
ISSN: 0140-525X (ISSN-L)
1469-1825
DOI: 10.1017/s0140525x97221485
OpenAlex: W2168132586
Cited by: 1,125
References: 0
Citations by year: 2026: 8 · 2025: 17 · 2024: 30 · 2023: 31 · 2022: 42 · 2021: 32 · 2020: 27 · 2019: 32 · 2018: 28 · 2017: 30 · 2016: 39 · 2015: 33 · 2014: 44 · 2013: 48 · 2012: 39
FWCI: 14.24
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Behavioral and Brain Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: sex differences in pain, pain perception, pain threshold, pain tolerance, sex hormones, hyperalgesia, opioid system, nerve growth factor, sympathetic nervous system, pain coping, pain reporting
MeSH terms: Adult, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Nerve Growth Factors, Pain, Pain Measurement, Sex Characteristics, Sex Factors, Gonadal Steroid Hormones, Sympathetic Nervous System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex differences in pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks