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Cited by 207Salmonella and Campylobacter epidemiologyFood Safety and HygieneListeria monocytogenes in Food Safety

Source attribution of human campylobacteriosis using a meta-analysis of case-control studies of sporadic infections

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DOMINGUES, A. R., PIRES, S. M., HALASA, T., HALD, T.·2012·Epidemiology and Infection
DOI 10.1017/s0950268811002676
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Abstract

SUMMARY: Campylobacter spp. is a widespread and important cause of human illness worldwide. Disease is frequently associated with foodborne transmission, but other routes of exposure, such as direct contact with live animals and person-to-person transmission, are also recognized. Identifying the most important sources of human disease is essential for prioritizing food safety interventions and setting public health goals. Numerous case-control studies of sporadic infections of campylobacteriosis have been published. These studies investigated a variety of potential risk factors for disease, often using different methodologies and settings. Systematic reviews (SRs) consist of a formal process for literature review focused on a specific research question, and include the identification of relevant literature, quality assessment of relevant studies, summarization or statistical analysis of data, and conclusions. With the objective of identifying the most important risk factors for human sporadic campylobacteriosis, we performed a SR of case-control studies of human sporadic cases and a meta-analysis of the obtained results. A combined SR focusing on Salmonella and Campylobacter studies was performed and the results analysed separately. From 1295 identified references, 131 passed the relevance screening, 73 passed the quality assessment stage, and data was extracted from 72 studies. Of these, 38 focused on campylobacteriosis. Information on exposures of cases and controls, and estimated odds ratios for investigated risk factors were collected and analysed. In the meta-analysis, heterogeneity between the studies and possible sources of bias were investigated, and pooled odds ratios for identified risk factors were estimated. Results suggest that travelling abroad, eating undercooked chicken, environmental sources, and direct contact with farm animals were significant risk factors for campylobacteriosis. Sub-analyses by geographical region, age group, and study period were performed, and differences were discussed.

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  • Contact with pets has been identified as a route or risk factor for human salmonellosis in several case reports and studies.

    “However, contact with pets has also been identified as a route or a risk factor for human salmonellosis in several case reports and studies (Finley et al. 2006, Domingues et al. 2012, Freeman et al. 2013), indicating that pets which have consumed Salmonella‐contaminated feed also pose an infection risk to owners.”

    From Raw diets for dogs and cats: a review, with particular reference to microbiological hazards. (2019) · cites this paper as Domingues et al. 2012

    The Discussion identifies pets as an important source of exposure, and the Fig. 4 caption describes studies of pet contact as a risk factor for human campylobacteriosis (page unavailable). The cited paper does not establish pet contact as a risk factor for salmonellosis or link that risk to Salmonella-contaminated feed. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Pets that have consumed Salmonella-contaminated feed pose an infection risk to owners.

    “However, contact with pets has also been identified as a route or a risk factor for human salmonellosis in several case reports and studies (Finley et al. 2006, Domingues et al. 2012, Freeman et al. 2013), indicating that pets which have consumed Salmonella‐contaminated feed also pose an infection risk to owners.”

    From Raw diets for dogs and cats: a review, with particular reference to microbiological hazards. (2019) · cites this paper as Domingues et al. 2012

    The Discussion identifies direct contact with pets as a source of exposure, and its Figure 4 caption concerns the risk of human campylobacteriosis after pet contact. It does not establish a risk of salmonellosis from pets that consumed Salmonella-contaminated feed. No page number is available in our copy. (LLM, conf=0.86)

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Cites

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Authors
DOMINGUES, A. R., PIRES, S. M., HALASA, T., & HALD, T.
Affiliations
Technical University of Denmark (DK)
Corresponding author
DOMINGUES, A. R.
ORCID
Venue
Epidemiology and Infection
Publisher
Cambridge University Press (CUP)
Published
2012-01-03
Volume
140
Issue
6
Pages
970-981
ISSN
  • 0950-2688 (ISSN-L)
  • 1469-4409
DOI
10.1017/s0950268811002676
OpenAlex
W2052878156
Cited by
207
References
5
Citations by year
2026: 6 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 11 · 2020: 27 · 2019: 20 · 2018: 18 · 2017: 17 · 2016: 16 · 2015: 18 · 2014: 9 · 2013: 24 · 2012: 7
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Epidemiology and Infection (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Safety and Hygiene
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Listeria monocytogenes in Food Safety
Keywords
campylobacteriosis, Campylobacter, sporadic infection, risk factors, source attribution, foodborne transmission, international travel, environmental exposure, human-to-human transmission, Salmonella, odds ratio
MeSH terms
Animals, Campylobacter Infections, Environment, Food Microbiology, Humans, Risk Factors, Travel, Odds Ratio

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