The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Are intact peptides absorbed from the healthy gut in the adult human?
Open accessAbstract
For over 100 years it was believed that dietary protein must be completely hydrolysed before its constituent amino acids could be absorbed via specific amino acid transport systems. It is now known that the uptake of di- and tripeptides into the enterocyte is considerable, being transported across the intestinal endothelium by the PepT1 H+/peptide co-transporter. There is also evidence that some di- and tripeptides may survive cytosolic hydrolysis and be transported intact across the basolateral membrane. However, other than antigen sampling, the transport of larger intact macromolecules across the intestinal endothelium of the healthy adult human remains a controversial issue as there is little unequivocal in vivo evidence to support this postulation. The aim of the present review was to critically evaluate the scientific evidence that peptides/proteins are absorbed by healthy intestinal epithelia and pass intact into the hepatic portal system. The question of the absorption of oliogopeptides is paramount to the emerging science of food-derived bioactive peptides, their mode of action and physiological effects. Overall, we conclude that there is little unequivocal evidence that dietary bioactive peptides, other than di- and tripeptides, can cross the gut wall intact and enter the hepatic portal system in physiologically relevant concentrations.
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Cited by
Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
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Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
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Skin collagen through the lifestages: importance for skin health and beauty
Reilly, D. M., & Lozano, J. (2021) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2020.153 · Cited by 241
Burd, N. A., Beals, J. W., Martinez, I. G., Salvador, A. F., & Skinner, S. K. (2019) · Sports Medicine · doi:10.1007/s40279-018-1009-y · Cited by 127
Holwerda, A. M., & van Loon, L. J. C. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab083 · Cited by 117
“Peptide absorption in the gut may occur through 4 possible pathways: 1) through the tight junctions between enterocytes, 2) by passive diffusion through the enterocytes, 3) by endocytosis through the enterocyte, and 4) through transmembrane transporter protein systems.(108)”
Background
Metadata
- Authors
- Miner-Williams, W. M., Stevens, B. R., & Moughan, P. J.
- Venue
- Nutrition Research Reviews
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-12
- Volume
- 27
- Issue
- 2
- Pages
- 308-329
- ISSN
- 0954-4224 (ISSN-L)
- 1475-2700
- OpenAlex
- W1973863973
- Cited by
- 282
- References
- 221
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miner-Williams, W. M., Stevens, B. R., & Moughan, P. J. (2014). Are intact peptides absorbed from the healthy gut in the adult human? Nutrition Research Reviews. https://doi.org/10.1017/s0954422414000225
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
