The DOI matches its Crossref record; 259 of the 262 references it cites were found in a registry or an index.
Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk
Open accessAbstract
The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents’ self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents’ aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multiple regression: testing and interpreting interactions
(1992) · Choice Reviews Online · doi:10.5860/choice.29-3352 · Cited by 36,647
Missing data: our view of the state of the art
Schafer, J. L., & Graham, J. W. (2002) · Psychological Methods · doi:10.1037/1082-989x.7.2.147 · Cited by 11,638
A comparison of methods to test mediation and other intervening variable effects
MacKinnon, D. P., Lockwood, C. M., Hoffman, J. M., West, S. G., & Sheets, V. (2002) · Psychological Methods · doi:10.1037/1082-989x.7.1.83 · Cited by 9,406
(1991) · Medical Entomology and Zoology · Cited by 8,071
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
A Direct Approach to False Discovery Rates
Storey, J. D. (2002) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00346 · Cited by 5,603
Socioeconomic status and child development
Bradley, R. H., & Corwyn, R. F. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135233 · Cited by 5,484
Actual causes of death in the United States
McGinnis, J. M. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510180077038 · Cited by 5,480
Robins, L. N. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290015001 · Cited by 5,219
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Research works printed but not linked: 5
- Muthén, 1998, Mplus user's guide
- Achenbach, 2001, ASEBA School Age Forms and Profiles
- Endicott, 1975, Family History Diagnostic Criteria
- Lanthier, 1995, Manual for the Big Five Personality Questionnaire—Revised child version
- Robins, 2000, Diagnostic Interview Schedule for the DSM-IV (DIS-IV)
Cited by
Sorted by citations
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33
Wang, F. L., & Chassin, L. (2017) · Clinical Psychological Science · doi:10.1177/2167702617733817 · Cited by 20
Self-citationWang, L., Li, J., Liu, Z.-H., Zeng, J., & Dou, K. (2025) · Journal of Youth and Adolescence · doi:10.1007/s10964-025-02136-5 · Cited by 13
Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function
Schmitt, R. E., Messick, M. R., Shell, B. C., Dunbar, E. K., Fang, H., Shelton, K. L., Venton, B. J., Pletcher, S. D., & Grotewiel, M. (2019) · Addiction Biology · doi:10.1111/adb.12779 · Cited by 8
GAL3 receptor knockout mice exhibit an alcohol‐preferring phenotype
Genders, S. G., Scheller, K. J., Jaehne, E. J., Turner, B. J., Lawrence, A. J., Brunner, S. M., Kofler, B., van den Buuse, M., & Djouma, E. (2018) · Addiction Biology · doi:10.1111/adb.12641 · Cited by 7
Baranger, D. A. A. (2018) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/2npp-kp25
Metadata
- Authors
- Wang, F. L., Chassin, L., Bates, J. E., Dick, D., Lansford, J. E., Pettit, G. S., & Dodge, K. A.
- Affiliations
- Arizona State University (US)
- Indiana University Bloomington (US)
- Virginia Commonwealth University (US)
- Duke University (US)
- Auburn University (US)
- Corresponding author
- Wang, Frances L.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-05-23
- Volume
- 30
- Issue
- 1
- Pages
- 213-233
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC6463296
- OpenAlex
- W2619295420
- Cited by
- 6
- References
- 262
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA022097, P50AA011998, F31AA023128, R01AA016213)
- National Institute of Mental Health (R01MH057024, R01MH057095, R01MH056961)
- National Institute on Drug Abuse (R01DA016903)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD030572)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- serotonin, adolescent alcohol use, self-regulation, depressive symptoms, aggression, antisocial behavior, mediation, 5-hydroxyindoleacetic acid, cerebrospinal fluid, parental education, sex differences, genetic risk factors
- MeSH terms
- Underage Drinking, Adolescent, Aggression, Depression, Female, Humans, Hydroxyindoleacetic Acid, Male, Parents, Risk Factors, Serotonin, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
