The DOI matches its Crossref record; 264 of the 264 references it cites were found in a registry or an index.
Prenatal influences on temperament development: The role of environmental epigenetics
Open accessAbstract
This review summarizes current knowledge and outlines future directions relevant to questions concerning environmental epigenetics and the processes that contribute to temperament development. Links between prenatal adversity, epigenetic programming, and early manifestations of temperament are important in their own right, also informing our understanding of biological foundations for social–emotional development. In addition, infant temperament attributes represent key etiological factors in the onset of developmental psychopathology, and studies elucidating their prenatal foundations expand our understanding of developmental origins of health and disease. Prenatal adversity can take many forms, and this overview is focused on the environmental effects of stress, toxicants, substance use/psychotropic medication, and nutrition. Dysregulation associated with attention-deficit/hyperactivity–disruptive disorders was noted in the context of maternal substance use and toxicant exposures during gestation, as well as stress. Although these links can be made based on the existing literature, currently few studies directly connect environmental influences, epigenetic programming, and changes in brain development/behavior. The chain of events starting with environmental inputs and resulting in alterations to gene expression, physiology, and behavior of the organism is driven by epigenetics. Epigenetics provides the molecular mechanism of how environmental factors impact development and subsequent health and disease, including early brain and temperament development.
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“Maternal smoking in pregnancy has also been associated with epigenetic modifications, including DNA methylation, that are implicated in deleterious changes to gene expression and processes related to growth and development”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [48]
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Cites
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The Cambridge Handbook of Personality Psychology
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822 · Cited by 148
Cerritelli, F., Frasch, M. G., Antonelli, M. C., Viglione, C., Vecchi, S., Chiera, M., & Manzotti, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721605 · Cited by 108
Provenzi, L., Grumi, S., Altieri, L., Bensi, G., Bertazzoli, E., Biasucci, G., Cavallini, A., Decembrino, L., Falcone, R., Freddi, A., et al. (2023) · Development and Psychopathology · doi:10.1017/s0954579421000766 · Cited by 99
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Metadata
- Authors
- Gartstein, M. A., & Skinner, M. K.
- Affiliations
- Washington State University (US)
- Corresponding author
- Gartstein, Maria A.
- Skinner, Michael K.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-12-12
- Volume
- 30
- Issue
- 4
- Pages
- 1269-1303
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC5997513
- OpenAlex
- W2773730878
- Cited by
- 161
- References
- 263
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 9 · 2023: 10 · 2022: 19 · 2021: 28 · 2020: 54 · 2019: 12 · 2018: 6
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Development and Psychopathology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- John Templeton Foundation
- National Institutes of Health
- National Institute of Environmental Health Sciences (R01ES012974)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- prenatal influences, infant temperament, environmental epigenetics, epigenetic programming, prenatal adversity, maternal stress, toxic exposure, maternal substance use, prenatal nutrition, attention deficit hyperactivity disorder, developmental origins of health and disease, social-emotional development, early brain development
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Child Development, Female, Humans, Infant, Learning, Pregnancy, Prenatal Exposure Delayed Effects, Temperament, Epigenesis, Genetic
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