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Cited by 27Dementia and Cognitive Impairment ResearchHistorical and Modern Theater StudiesAlzheimer's disease research and treatments

Frontal assessment battery and brain perfusion imaging in Alzheimer’s disease

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Oshima, Etsuko, Terada, Seishi, Sato, Shuhei, Ikeda, Chikako, Nagao, Shigeto, Takeda, Naoya, Honda, Hajime, Yokota, Osamu +1 more·2012·International Psychogeriatrics
DOI 10.1017/s1041610211002481
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Abstract

BACKGROUND: The frontal assessment battery (FAB) is reported to be a useful tool for assessing frontal dysfunction. However, the neural substrates involved in patients with Alzheimer's disease (AD) remain to be elucidated. The aim of the present study was to identify the regional perfusion patterns of the brain associated with performance scores on the FAB of patients with AD using brain perfusion assessed by single photon emission computed tomography (SPECT). METHODS: Twenty-four AD patients with high scores and 24 age- and sex-matched AD patients with low scores on the FAB were selected from 470 consecutive Japanese patients of the Memory Clinic of Okayama University Hospital. All 48 participants underwent brain SPECT with 99mTc-ethylcysteinate dimer, and the SPECT images were analyzed by statistical parametric mapping. RESULTS: No significant differences were found between high and low FAB scoring groups with respect to Addenbrooke's Cognitive Examination scores, Mini-Mental State Examination scores, or the depression score of the Neuropsychiatric Inventory subscale. Compared with patients with high scores on the FAB, AD patients with low scores showed significant hypoperfusion in the left middle frontal gyrus (MFG) and the right superior frontal gyrus (SFG) extending to the left SFG. CONCLUSION: Our results suggest that functional activity of the SFG and MFG is closely related to the FAB score. The FAB might be a promising strategy to detect early stages of AD with low SFG and MFG function.

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  • In a post-COVID-19 study, COVID-19 infection resulted in executive function and language deficits, as well as lower scores in frontal assessment battery, as in AD overall.

    “This was observed in a post-COVID-19 study, wherein COVID-19 infection resulted in executive function and language deficits, as well as lower scores in frontal assessment battery [86], as in AD overall [87].”

    From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [87]

    Citation [87] supports the comparison with Alzheimer’s disease, not the preceding claim about COVID-19. The Discussion reports that some patients with mild AD show frontal dysfunction and that patients with low FAB scores can be found even in early AD. It does not establish executive and language deficits with lower FAB scores in AD overall; the Methods describe lexical fluency as a FAB subtest, but do not report a language-deficit finding. (LLM, conf=0.85)

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Authors
Oshima, E., Terada, S., Sato, S., Ikeda, C., Nagao, S., Takeda, N., Honda, H., Yokota, O., & Uchitomi, Y.
Affiliations
Okayama University (JP)
Corresponding author
Terada, Seishi
ORCID
Venue
International Psychogeriatrics
Publisher
Elsevier BV
Published
2012-06
Volume
24
Issue
6
Pages
994-1001
ISSN
1041-6102 (ISSN-L)
DOI
10.1017/s1041610211002481
OpenAlex
W2138064754
Cited by
27
References
2
Citations by year
2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
2.51
Type
journal article
Language
en
Open access
Licence
Locations
  • International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (21591517, 24591714)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, Frontal Assessment Battery, frontal lobe dysfunction, cerebral perfusion, regional cerebral hypoperfusion, middle frontal gyrus, superior frontal gyrus, SPECT, early detection of Alzheimer's disease, cognitive assessment
MeSH terms
Activities of Daily Living, Aged, Alzheimer Disease, Brain, Female, Frontal Lobe, Humans, Male, Neuropsychological Tests, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Case-Control Studies, Neuroimaging

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