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Cited by 34Treatment of Major DepressionDementia and Cognitive Impairment ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The Effects of Mood Changes and Antidepressants on the Cognitive Capacity of Elderly Depressed Patients

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Georgotas, Anastasios, McCue, Robert E., Reisberg, Barry, Ferris, Steven H., Nagachandran, Narmada, Chang, Irene, Mir, Pervez·1989·International Psychogeriatrics
DOI 10.1017/s1041610289000141
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Abstract

Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear to significantly affect cognitive capacity; neither did treatment with an active substance as compared to placebo. In addition, the baseline level of cognitive functioning did not appear related to whether a patient responded to treatment. The authors conclude that under optimal conditions neither antidepressant produces measurable changes in the cognitive capacity of nondemented elderly patients.

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Crossref · 10.1017/s1041610289000141

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Authors
Georgotas, A., McCue, R. E., Reisberg, B., Ferris, S. H., Nagachandran, N., Chang, I., & Mir, P.
Affiliations
NYU Langone Health (US)
ORCID
Venue
International Psychogeriatrics
Publisher
Elsevier BV
Published
1989-09
Volume
1
Issue
2
Pages
135-143
ISSN
1041-6102 (ISSN-L)
DOI
10.1017/s1041610289000141
OpenAlex
W2100347963
Cited by
34
References
0
Citations by year
2024: 2 · 2016: 3 · 2015: 2 · 2013: 1 · 2012: 1
FWCI
1.61
Type
journal article
Language
en
Open access
Licence
Locations
  • International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH 35196)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
geriatric depression, antidepressants, cognitive function, nortriptyline, phenelzine, mood changes, treatment response, placebo comparison
MeSH terms
Affect, Aged, Aged, 80 and over, Cognition Disorders, Depressive Disorder, Double-Blind Method, Female, Humans, Male, Mental Status Schedule, Middle Aged, Nortriptyline, Phenelzine

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