Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment
Open accessAbstract
Wide-ranging conceptual and diagnostic approaches to defining mild cognitive impairment (MCI) have led to highly variable prevalence and progression rates. We sought to examine whether bilateral hippocampal volumes and cerebrovascular risk factors in individuals characterized by two different neuropsychological definitions of MCI subtypes would also differ. Participants were 65 nondemented, community-dwelling, older adults, ages 62–91 years, drawn from a larger group of individuals enrolled in a longitudinal study of normal aging. A comprehensive neuropsychological definition of MCI that required the presence of more than one impaired score in a cognitive domain resulted in expected anatomical results; hippocampal volumes were significantly smaller in the aMCI group as compared to cognitively normal or nonamnestic MCI participants. However, a typical definitional scheme for classifying MCI based only on the presence of one impaired score within a cognitive domain did not result in hippocampal differences between groups. Global stroke risk factors did not differ between the two definitional schemes, although the relationship between stroke risk variables and neuropsychological performance did vary by diagnostic approach. The comprehensive approach demonstrated associations between stroke risk and cognition, whereas the typical approach did not. Use of more sophisticated clinical decision-making and diagnostic approaches that incorporate comprehensive neuropsychological assessment techniques is supported by this convergence of neuropsychological, neuropathological, and stroke risk findings. (JINS, 2009, 15, 890–897.)
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Neuropsychological criteria that balanced sensitivity and reliability, and incorporated instrumental ADL scores, produced more stable diagnoses over time and the strongest associations between cognition and hippocampal volume or stroke risk.
“Neuropsychological criteria that balanced sensitivity (which defined impairment below −1 SD as opposed to −1.5 or −2 SDs) and reliability (required two impaired scores within a domain as opposed to a single impaired score), and incorporated instrumental activities of daily living (ADL) scores, produced more stable diagnoses over time and the strongest associations between cognition and hippocampal”
From Neuropsychological Criteria for Mild Cognitive Impairment Improves Diagnostic Precision, Biomarker Associations, and Progression Rates (2014) · cites this paper as [20]
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Experimental — accuracy not yet measuredThe lack of objective tests of other cognitive domains reduces the ability to detect cognitive impairment profiles that might identify distinct subtypes of MCI that vary in clinical and biological characteristics.
“Finally, the lack of objective tests of other cognitive domains reduces the ability to detect cognitive impairment profiles that might identify distinct subtypes of MCI that vary in clinical and biological characteristics [19–21].”
From Neuropsychological Criteria for Mild Cognitive Impairment Improves Diagnostic Precision, Biomarker Associations, and Progression Rates (2014) · cites this paper as [20]
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Bondi, M. W., Initiative, F. T. A. D. N., Edmonds, E. C., Jak, A. J., Clark, L. R., Delano-Wood, L., McDonald, C. R., Nation, D. A., Libon, D. J., Au, R., et al. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140276 · Cited by 750 · see citing works
Self-citation
- Authors
- JAK, A. J., URBAN, S., McCAULEY, A., BANGEN, K. J., DELANO-WOOD, L., COREY-BLOOM, J., & BONDI, M. W.
- Affiliations
- University of California San Diego (US)
- Ohio University (US)
- Veterans Medical Research Foundation of San Diego (US)
- San Diego State University (US)
- Corresponding author
- JAK, AMY J.
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-11
- Volume
- 15
- Issue
- 6
- Pages
- 890-897
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- PMC
- PMC2864786
- OpenAlex
- W2158077840
- Cited by
- 51
- References
- 2
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2012: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Cambridge
- University of California, San Diego
- National Institute on Aging (R01AG012674, K24AG026431, T35AG026757)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, hippocampal volume, stroke risk, cerebrovascular risk factors, neuropsychological assessment, older adults, normal aging, amnestic MCI, cognitive domain
- MeSH terms
- Aged, Aged, 80 and over, Cardiovascular Diseases, Cognition Disorders, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Residence Characteristics, Risk Factors, Geriatric Assessment, Multivariate Analysis
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